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All Rights Reserved.ITC Garamond is a registered trademark of International Typeface Corporation.) readonly def /FullName (ITC Garamond Bold) readonly def /FamilyName (ITC Garamond) readonly def /ItalicAngle 0 def /isFixedPitch false def /UnderlinePosition -100 def /UnderlineThickness 50 def /Weight (Bold) def /BaseFontName (Garamond-Bold) def end def /Encoding StandardEncoding def currentdict end currentfile eexec ލFx ʄf5ku'0oߜhJCd:EqYe6Q3Kt9%|Άf*eY ΜlєZ%_@t =_gZC.Ȩ^Y"m* lѩ4_{:qV_(ߵ[)/}ҟ@][_qL\Q9nIE\4R{>IX sfUet[f+9+ Hf\2Ag֜RA Ƽo9AW$@9>KkWRgҬy#egͅGέD?z@G1ف߸uT 1rKA!R$yѬчR$`Wid֠!mul[פj3DP[ě7Tٜ^*x’3h}/Џ ª3ן1d(_ue¢ UKmA%\*JZ(j0GCny^bJ}B.'R"JM>x 8bXSR&Q{Q'Ϫ .2ٴj]LjHLI(,E Iiqv.Ly.^霩B6ȵ|YK!@sMK,ݼ!Y*S؃\1۬ KQqpLPh4R#f98 GeK(X~ DvTKȤjN;ܾH ~_wT r *5۠4hA/z( \++\Ѵ2hCICqYx3[׬~+Cd5 !x|6N2gd+nG*aUj"B2NkÎ?x,$)zA,00=)F rM˛_B ]BFylmXS_Ts<.+ 2iϬ_˚uN&ag 5.8:aLQR:5aL*)X #hNǷ 珞pycʆe5a\dcdUb&-'L}8qUY0RYZ;] C_րaלM&CS4Z#*)K:Rg5UnN_?l }a*#!g sueϦX6U883ɱA55GSV5 ] T +}th`5f{3n5)H8)\5.'s-r'quZQv+:,;RWjt\lPb~{)~4(Lv厤. ^T$|3{R äpkcgkQ0_A憥::C}B%)`ZJ` A&+_+ՓY9Q.St.}ZpFgThv񤟃MWJ+|Lm}Ov3$6r+C3Lo?ժXluEb'zb8`Ќ&JV9IxE/ݶR&ʽG فWm/%2`Wɨ $;C5{X$.L!/H+,`aa2=!6ҍ-t1 _%= IUO;=3yYL2qhWqρ7O# GIF:y|\hM~{#oGqӷQe2J;ٷ-n^\@YβB"isS&R7Iأ<&AlJ?*J@(cm{{w Gp"#`KFxRإ ;Or>1<;e?虙ŵWck;ԵҐU#ZqhrĻa}. 8d)o?vz5*H\ Ga$g9"T)_JͺXCy'i@No8m 꾥,msA!:q~kg,Y,ydgC.ͨӓ\ȼz%4<}}p(|(\`wj?=Q+"Cv"NWo;3_G+Yjcs'U pzF @AN_.d)#USW1Ϟ f8F#yΦ࡫S(Ύ} 1B1:"Wp"q$Hp e 'ݮ׿5dIUٚQr^yKY¡@yhf@ru:41]{A=psr*4ק7窙bߛj-?▌VG>n}yzw6!\!8(2Vf% #Pj>Kᒹ`qk{}Pǩ{wS>Orސٶr.:^ 0pKS"$> &.?`.(f(N"1\ԓ{F)? kjC4s-C>B6ip5߬yڇ.^M)wWvź][8vhf_G:HNߴ0yR`7"yњ_e2ÔBsK!eZH6V5]sKuCM״Wq ti`[a7J=S; L>`kzHPqL _ r9 ѳV4rS+B MTir :h$ !,V-OᎲc1vynEeI<^tS۰(N qc j.DI'מ<@+y*Ҋbo}Dţ|g[ӝ:, <.2{N ,&`I:! uRI,M`B|+N;IY  IfB@VI轗kO'=PqMcUEqz([av;Ɖ\6hi= '^TݪH#*3F+NA404?dU{̓=uG,6"^"v$f *^:T,BHvW{_bZD7w{yNn1ɭ+j;j~p ۾ê-H֌LC 1Sdes-$V4.'A@Lo?l Ey/W}Tؤ&Lo#Ђ² iʷ2!/e]X|3x0+xfuheYbi]#JFV2&|&#Npj'zKgNckȦ& )TpսeZ%,fA0m:nyQL4tTg¼ 4fS HDx-wnD'lzK[0N,'ce>^dB'g}K1qzdvOF׾bBTu`p_68峲ٮ^COdک,DQ I}^!Tّib(wW(>;E TZhu`G 88SV{:GBZߢm\)(!!Ψm^F?#FAnHI@vVb#aׇ5~g1*:gm5Cc%v$V }رOL!$0Glnfg%4 a^jN-n%.]F<-Jbd|< md&剴y*~hxe2_ky ϗ y*ÕR>#e{چ*XLP+z]Cyd[ Nk>4&m|2dQ,V8:jcIL}-r7`{R[Xo*ߡ*“?_ѥAH'89)=Vs"@춬@".kEou@w -xڞ-[,컸Ȳf BUc! qAXȫfPh|4GKƟ~ZQ8{AUY<~<\}:jOg m=ByVS4(PwIjHl X$ՐÂ1zE;kpʌ] mf{b%7˒8`&dCacԳF#g;EWԡ @gEA'Ɩ\-juX[h32@m3ܷ =nQo,CFbxQUrq#~'wyCCkX'Dm`OpNE]cy At.Fr_Xfʅ;"&=RƖ UhNkIviڳWVzkt 9u:R+?b"}{c hL F\f7S1IQ%pI~W`mSYx.~8ji%r n@V;_0S 鐯 UҶT 5/vX4;S ٲ̣Dr;:NS Oe Ov^A vb1x:F/![Em(рw{8%mPs&ژClA%&pE9̅ĸfڄ31LhƣLj/5+#53{ʔ~dA#ǁ}UHp-뚲?7%k 6ؔGy#<2Jʥ/Q-wWZ}Ю]tPQ@ Z}U -9*-63lCBy eGS8.MVCDXkx6IR*i?fOwū/ 3e%;:rL X- ,co4e0P˲$5:eU!mNS|KxSf{1@ǭ0}v/0mKZB1a.>5喰¸&.<;u&NO'ٛBt_%|,@nCL",Jk.ՏQqh`>? r˵*d}a2| ˜%׃(ޥN^|=J |cY4_RAr/Z91`>¡>.q<_kR8 i;&^^éE=Y>'9T{$F^eB, ƍ5)zf~B-bD§fQ4mpf0 .T_E…v4"ZWT)]_DNk3s"ĪvۜchXYӕZs يjRm3@H4%ctv @F~݇;^MJ(zHFIOLQPk5$]1M-5cc krZÌ (^}m\4jtvDfyKۮ‰d]Q3Ŷٚi ,E|,f\nPscC Y26\(4?=F\t]RQhZEd~()*Zlgxp0WMu_.$V6OVD;:3 xaNyEbCE Q;tQ zukF_^X&yCzimwhH3pRJ`t Y883ΚhRgG8ʱʲ͛ߊ*Ӳ7(<ɌE:m\6WQ(!KiJV!<Βқ]w(>oo6L%2 ޠذH=F1((]1I̮ SC܌O9SNR].,v5#1yaH V.-p*vt?MO?M7al#W" jm" 2f (b$ZA&Z?E(ce"glnRx$f&)`060`7U 1Ł͈Uܥ*ȭlc ͩw |d5M6|l[1#Kkl~WHkGk((HX> ɕe\btz|$ÿͬF1xOh ׵B@=TLIe-ڰгczͲ&ѿj1$h:A|R`m섵a@VΜroT&vvkIv,> kUd 7/khz=RaR]5T L00W/{R8dϱ%hɫW|r?8INt.L$8;3]U6RQSe" \lf,oҜu\:*=3k+/֮I) UX?$Ap ΤEb F{5zu@gWugҞgb<}댖qi+Sr-!P?06P-t|CÒT Ko}.ASFϭn0YFj0dWSE}zk[^# )$j$R/nH0(k>DLoMCHPUko Y ¯u)FbPVQ|Ҳ,IH񻌪fRI1Kd;j@U `V0 ʍMh]XOLIsN (b&WlB .i~5d F#9iiu 0(y{*2]uC'Sª*ӦYW$]yɫ֞}A-i}ᗞR 8xz@:_N;6↹@7ّRE_I[V̀tY978A"{CY\UWxx(&n2 ^O(xqmIcJU\3UKljٯqV6ʕδYAfW1xOKC"&/_qXDȇa鐵=y.OQVQ quc=dmGha ymɵ ^Tls^t+F`n@d3V^ښ\Ei$H7mv̗EY]o;tJ,I~2WmCp<3zs>>┕8z ͹DhJdQURXFs ~oRqhcBk7C_e2Nl(1]lS$?inC @|  NQI6?jO{ZKva39NIeXxTx+Mdy7{ͱTmvVHWqvKݞhDj?1SsD,8H4і:D&ԕ-(}|\f q2Jxráْy.kJׂ htixFQIL8JMԹ*}mD6}h\2SmbЊ-|ktEh,Q5FxWְΧ I9rrz U$&%rfzLDatﺒXx;Zr@XeK`#p.->mDmׂ^Q*f92_LYI@jAQAg Z47c;*v !WA|]#%(SpYWT|wwk=># q'Rd*Qu;:{+ )#Hb4UA"ytmMgY1C`E ՍY,@=S/pcd!Ck[ưacLِ3x}f7t7)'mEmw<Gl)3Z|[oȍ[ʡr1 ӷ,AAwײDžd\ KJ/S}ھ̽e]_XY 7 B),8 [,'`d~`8SJXabu "?In~@P˫I%^QD# GF3[p>S}U ZK4ʫjTB>Nx+ =jLO2P) )8Ø7V W;>\/Sq96t-7Vz0^GP>wAsy@gs6!,|w H;!)󞁯mc-XLӓ(Ͱ :w{MPmyLDЄ"Hab&JJXjr;%Uýru )vrtpȘOiʵZ[y޸@ΒTR:=%ʼ/'g# @GVJDVcdMG6jdtyAk0a,$pLz^:.@S!p=B]{.g7XjP-ш?Qm$ZZ&ZUP"Qb4g ~W3IV {XxX_eNjU  r|_ 0{35ethe^QC*o&2Fxk?Gl{ϋ׸5Ky+ 39=uَZ4Eꎽ;e`) oWoTIU@[@CSp) Ì]Q]Ჲ)&okm IV؆ >E/CĐ2>uk]kૡJ"s{$q+m(v4{Z\ 5%1ӄQp ''-2ܠvgTx3pS7|[VW2jքz;3@my[stQxvNEQk-@(7AJǺX3xbLXAk=LTOnHp̹E\Gu]7 -4]?ख़0qzm%#T42Q"zZ5:#8P(d뼽krZJaPQ8l{WçUDNаx+{A#x|%Š^_:R MI;}0@[3>Cw%E'J>3`Tzkbʆ _Gwb'*k>"#DձM߾2<rUG!ЫP iLN}J*딃 H4ԳE  "EOX]P+q?Ilӝ{Qeg KVʟTŮӘY3F<'! 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All Rights Reserved.ITC Garamond is a registered trademark of International Typeface Corporation.) readonly def /FullName (ITC Garamond Book Italic) readonly def /FamilyName (ITC Garamond) readonly def /ItalicAngle -17 def /isFixedPitch false def /UnderlinePosition -100 def /UnderlineThickness 50 def /Weight (Book) def /BaseFontName (Garamond-BookItalic) def end def /Encoding StandardEncoding def currentdict end currentfile eexec 2àSTXqZ YUt I,`«2?=g8۴IK[?biK6_娣L$ )"j8)xW;T W|pއ+XA \3L=l) vcEP]- rT,4/s%5縫LDu|WڕQ1y4pJܐ} _'Utms;;9-Br'_)ŚfQ&2>P930ž>"[+=JuD8 [2ē$%!|a.U 䞻Uم]oa9N'G.;q.bsF鿟RkJ1K|Tl{DU@ej72|b<5OwdHXVK(WU &1\w&}TMh~JD:N\xf<1Le+_Sqm|DTV_һqXy*b.4[1ǵƯ|G2<Z /+8.݊c &"NX1#pC!ʒ8FQY??$m.=AXˆ|pkaet\oo~2|Idp]EJk,K5.V>hd?rnP 1n !izh `L4U?[0V`8aN';'&5ꧬH+ت>p-t2pCJ FF慺M /W@ˬ}{)5OziZfp6`|8eu~ d&Ȉon]*9J~aurÄ*u ]vW^'L̕h&Mn4f $[2U%+hwFd_meѮ/B^V#C1p}Ŋ1?43F&=?RQ!o1ՌH^*~ ^g_j(E'IJW`$82}J')ﰺ-Zj`F<;mى jE_cONeBu`E\@~)<*vc*Pr *`rt㙐@*R;jDrr"A>?<8r-gXL<U.Xd&ZMpHR[ݧDZmy[Wg͠ ̹R;`iG6j Rw|?g b̫۴ J A]:NF3 8|I&SZĀUpDŽCGa11OpKqIGe|GUA.\JX{ I8|,g'@y;YY,y[a/TfOr[LU9SFqMR+ #x;#GUt74c/1e$I Mj{;#o;՝DZd_t>b3ZlWm=J#G4K+:njk,Ӱa)h%{lMG -"^w+E+>(涥4/)]=d#AQ ԳR#Oy%}R8FM o{x\Ң /mmQ'NcJy~ ^o/B#.rV^.X|`+{#NB$˺;g;ۘ=ܖ(̏=*Ǟh@r{SKs9Ϝ0a'L?$eī6 +߁k+*{Vʬ} >(maa[zFk`{7,KM=5&*aai X%y!+!'?EnӲuw}&6Ma.lmrԨڕ 2SM,?&&gz'1xWp9Y$*[Ԩ|_&"B?E0Qgl*ʗTp?06҇94+ F럼!ihm;VL_yLq>, F%~<8Bg]d&WUO89Wb8fs`<™<,F(=lEt 4FR뀧IUBZ,KZA5_:0IcIGxAޫekyܕ)7.•+x‘DQۺ)bC/V죴\36h\+GR5p8O}i.τ A'ኺOw[bŅvtldPǖ$ucGA|h:GPhϚ s)B2y*Xpth~JZDެ1zIT?"QVŚ4TJTf@26EB>傄T`V6s.6`nS_BQy Vfwɔ =HJ,YZSZ]ˌIA*kԔ[|vl4lgDe.8)CCH&۴7r LuHtN} *§SMnhh~ M.B\GkRH([9x۲xIt_>}.|Û> s=S .bރZ%/Hآ7cW~5o4'l;7,PV^Ikja@E\r܂%FC"6,u4U{nj"P@b}bS~?tslp)q ?gUR!;^^Ck.CYXhGV\*c2ʋ#g kwfCL{.~8zb/!9aRJ ,II-J쥜o%& 0)δ"ιϞL6-. .U807 ̺+_MM7|8A~lt8/rVJ%6z{n*7Б' w3?_7QK9L‘SCpvqEK$ԍ3MSa -lmPX0&U>ll֢ޖKO |sP{i#iZC`8#bQKY.0fʰSDz3v\UYAa/5W*| >H۝c7v|m?;OyNt.mOmİ11&+5 yiQG|ډǕ7Q`96mp3ڐa< kU%"r|4hn\6dc/TVvZt+Kձ~pӒdcƭ4ȇTH'q*j@vՈh )#}iH19'mGǶelˆ`T /*e=~-+#&#1cp "[GK zԀ 33kLKEnMpٽqlN7R?5gDt15]xi!wePX A Q-0Nwz !4) dİT4S (蜠hM!8si CB%UֺgX3 :(pQ%M/[Zn:Է4.oA^K(E19 rj t-b&gRۤhUk%2OuHY7DHq 0PSé[ODV`DXnSzDm%#d$E6yt.,X&ؠȜOfj^gnpZQKt''o(~iVFEyL8hy((4m$舿͵Ja2g/o#ƃ1}bT4>fd BZ_^`uǰ̓gы8ĺ{6emEj=IjU LzhڌH $f%  סߡDC8VJ|? oev+v2;*\ MEε|nw~\I;AѼ6 9J}ܦeVnɧ7<:B֫x[=o7"ï3:~;֛a$fڰ y{8o+Zul/B ]z50lgA~vvݟ`1[D .d[#]]ߑDae-9~"*^MgY~W9dR۷[­a#,<pK8E bk?`j7%Ҙۮl\0l;yXˁRڀ* k!zkF=()d~!cjMPc=k-a:$3|*m'XKN YMjmE "Pz=U kr a,jjBonR"~UrLP9iK]ʱ&;Jۗ4+N+WöFxOLs7Ҫ>x-F}>^'VwY_fB`3pR/&1ۚDvAw سV^ƣτ/b1h_G˞ `wj+$NoKAêqA,Rq cа\߭D x{H[ ;=q 5 ~L 3w󺏿r&`|R#,WD{oxXCIGE9K^8#+sFDF%LvްJKIO ŨĭdK-U*!GO- sx Fu.:be>+ leZ 8S[`ϐ1l=}N& VFsq'_+p^d5 QP1pML&Ӷ'SR1ÙjVKu:i. -Q8<0UNP)UcݫFv_diVMcmw3˃aWf)fӢE9'<6𚘸 }/`_JJ&8r*-m;Q3}Li~]3\(6@_weHUDџ6D{ /3wWDR$1IwwЦܚ?47bs2XY@x/AO5"5YK1cw8HӎW$G կ]Khy*pX>mvwY7^+*靜~9Y _/sD]5&r`2Y .,۟u{/?Y;-fw}D,rx=}ù7i\,P մ=[ QLn/ 4|QN%W!:T!{{;`wB=1J\َZr% v j)`sȦ`IdT0Kʹ}e~"?Lh"(!%uSyW1U2|J#.Lx(n`ҠYZ!8L(cC"]v<kX$]O.EK4 u[$KV>ղ̧!,ȳ?(ٰrǰұ-$ɋ,7+`=#ളʼAz\sا.#59[5jMhX}:aVKsQAY^Qt|QF wБ{Flhtl(Gh/72Χ$ 0Ht^=i&'F^&[mpuc[ix`@\u(', 3+CSxl[ fz{wa 0lZTdV=NR$f CTXP6+:;j*%r~c޸]1:}Hƞ@RXD9zc-ԞͮdQR.CceXK@kHTQHg'᪃$@P$cPw; aVVMtjػl^B&tVؠw߾ð"a8kP命Q2Gh#d K9?i|gM&c F=UZnp…j^MJTo^XԊz֩m+e";h8[aiC Z\t׊_=Q:2- ށMND:[|5aC'q睝!rme~hP0wCP| i Em0%W&(fJ_F..ϙt^@;)-UE_@Q"8k` ~h/뚳aלCmkC$\Pu_m!?Iۤ/A҅aٛi ]f3 ,8ORE|b1):]{)(PbcdyW66[']և#}^s!=GokUn2|gb$s7Ge~mfִrr07 /'P4!`A)%.J4 i(܇&r1,75ZGm)"}7}=lUF,LVMfS=S?vW/ {`PF `n@^E"->XTL.Ì?h93ALkgJVwZ:n4M4Tǫl9m‰TC` 5n;% Χ?@Ss|6RpJڝ+n}uiyc?tb' tpqU&P} {[8Cztg~o14ˁ'57Pe$y=  ݩ۫'(xB~c.Rd3hE{lFúV~!Cj)59z1=1D+ $> =6y}~oQ݌>|ə_VH$6 m#Df*~*u"zg l&q|+*4o&P0 _т=RE)΀Bm11xhAZXTi>42Tjw_֦\)CmLWY%R.ktxSxHi|Nt*2Nb'ǟ?lŸ=V(a6r̉|ge ج䊣5 fT4nܶcԆrwvL/ozI[@C];fW l5R;4^zhO3lR^*X,WĘ ѣ,{z l@!kx 4m"idGT"ٳ)N+.#7:ߠڳVNi/ԱŚh9p˙˲_tj,GE)L)[-M nzw"k6XU,Gƞ t 82j³Fu4dTMy:|#P"Y'ߧ"I="NPbrg ;Q$\q7~]g4} l z%X~%۟/L*,zR:&.n} t$pznE3qpQINR#{ b9۔uF4mHswؿ?/ WAo(uA"yB!Ùlc ^ؠWglxJſ|TiY8S&cc`7/3%fvxU:"\Y^Ł]~/ev5}V:F`ELU<8Xꑊ$^0ЕqS-PdC \ȳ)S7X7t_g1MW XRtK,3.G;18m8+7f-fb2Q^c el HU9*wt_sb,i\ ZZ@}p~cOVECT`[$NDۯ6w&*Q&x;-=Lg({#<'7 U0u+SCGf[&rUnd~}sBVLp &虞WQH )֙Vp{vuyh3Nicgx:"DUwՂͻgu+7oKlNO!@IRU.1ӐP1Fe3xdW%$CkkUTPʘu~Xsua_U@pE0&=Ӹ@u}kB~Ѥ1u*e %=f䘙]rA!Ĭ;zA*x{ܞGaZ: 1 ZALЂ3cn*&uAF?VKL1DgRⷙO.6{O 59yCguFqaTTaD8'X`jSJFY#eKr` W7FS"ã͵›hKB*,ptWgiYf𡃢SROΌr 9MF1s (VZ qè hὑU9vݺLWA! 2lN`ʟrtz5=z{K7,^TekMwZv95!>09d:Y1m5&fl_OQr^PH6JMP`qj"w? K#]H(Xf%%3`6l)ڮki{d>"yVebX#w y/j~-۪EeÜô濐ܚ\ʖ䑫܏&+b3cd#=UqO@AyKb ? Am n7~vfrs[2 SlУJZTHfTiLpÛb}dNeƒ4s.Yo<N!xi ŀDzql~2-REj(C +J%rF^,XJOPh+FzgOuÔA[)Dא4$a 8P%BA.iuffkt endstream endobj 82 0 obj<>stream %!FontType1-1.0: BPEION+Americana 1 13 dict begin /FontName /BPEION+Americana def /FontType 1 def /FontBBox {-167 -250 1006 883} readonly def /FontMatrix [0.001 0 0 0.001 0 0] readonly def /PaintType 0 def /FontInfo 12 dict dup begin /version (001.000) readonly def /Notice (Copyright (c) 1988 Adobe Systems Incorporated. All Rights Reserved.Americana is a trademark of Kingsley/ATF Type Corporation.) readonly def /FullName (Americana) readonly def /FamilyName (Americana) readonly def /ItalicAngle 0 def /isFixedPitch false def /UnderlinePosition -97 def /UnderlineThickness 46 def /Weight (Roman) def /BaseFontName (Americana) def end def /Encoding StandardEncoding def currentdict end currentfile eexec MQ: DqLo[J>gC +n)c\01ǟ q|(D?$̤cc-Ăcboiڄ٢LEltȋǺ>GI%. E8W2U*N/pmڝCBJg ͻm t$Rxd$94ItG}_wbxi^<[86}:߼% k#9=WI8bd7 G$Xv$B\xrrOvl>1?iYS3 |a`Щ)( ΊveEq P#YbɈ tv7r`I_pMjʄ=rsζ-PߧlƟ#)J;ohh=FYcݾNuYeAGQ uO>1gX۴Ϳ#$xuj MfbRfXN[q]#_N Yf}VtxwaJ\oMY's/wR"?xS1Xsq*|D Azy1wU1=:,"AuԴf>6dʵʲN< 2!\łH:҂p>% URɻ8#m3=Q 4 8ʽ*Ϭnaޔy ˮg6-{yvnErG2.@2SEHU\5.\%zm!j=@jK6g(r-hlr-0XH}7t-`z7t5ڸ&[IHQDqn/ǞQxX;he剞}ľiGV!Ĩo;3ŵHCҴ 5fN;$F(MPBDz?|wMSsuxY<" ـ2]"-*JLyO+ِ9{pe_%`LAx8=:#yK_PGRlcWaeH@O |~dSؗ|H"I>X+N$ۭS Eq9*9"[&Xjcc]q\xs(\V:vDIfUžZ:V2NSΧf呠^l=_;vha?ׯ_U l*Lb1Ac@CWF%_$ޖ \Oa,Z#QV)G5-)8/ziM&FS.ۯhɴTjK}nZZ,ܪ+D:=E!7?Jv[QR_ `bmDa}&vJD=.UbݗlPD M?$En]JI7H1 ,-6N9M|Zu웅B4},Ch1yޤ+=wN,pЃ2g(LǏ :Fkhqxs`]x!VT^綂bZad^#*ҹ8٤CVV"Ztp+^iP=Rm*vt}|%af%JH_P) e5>ܞ~/tcSʈ^LF ɞF@ST! 4[+@QծuVU 8y6i 5qW+kj<( Ku۞v ِ݋9F1 .lRԀ6#4-E|[ՀI n0 *k2͠喫w>[4Pa w'A8ai'_搇 !opg l$έb_zjhA ~#;]7_~/;Eddn,.nn,J!4J}W~ Q0%G0FݐT@CMuId5ʎ ?wrM8ys܂昚WB ZLi3-wu ,8ѻZ_컻dq!"b(_4(r 1q0ČFN)e}ɏ*iLj/q3&\a6JtkuzTVzw^y+)$^荤ΞݫR8t0ͨs$钭Yĕ E!bk 4ԉfKe[K5qt悯'Ҋm nN;N2;aw}J5$ q`t|BL²0QmB9݁FKTuG `k5w8΋-N'=pSx5MVB}#Nz)j(S-Gȷg9gg -q)= ؍#}\$ !/2P|RhnBL0Y=j)zDxPk׎@.b݉+R獂@F]f_Gäk4e+ҲŅ.Z>Ʋ*'$ұ0!)+0<:&]h>q Q:{ &eu%4Bxjt!wA- o3nP2T nHNMTX'YXux+1Eg]|۲Ȏlp|r[*ݔ/s*.ѣ&9p8Qi:_c~;AGqP7C42?<D-*l_S.8:p,Sd24/\ . ^E:MmXS7U&倧6)B]o.)f}4,I\" d>q=ŇԒ0vSڞ-*wTC|sҝV%.Zpmo#U ?x'-LbAzU:+b`dũ|BIGbJ}Q! 5e|2]c bcoDyJY41}#`lf%Eܳ7g*iFEot2F\6r+DUfqϷC&Éߚv ͥFwҁs J踠RRW< #/nꢱૄ eCf7NM9s)nB,`܄)BUڢ5 etgR\vahM7Φ~7rٱ}aN;ÀbPѪ^6Kyij<@J"mWO¥ q,?UV__l- Xc~`ocUS3F%Bx/h@~ڂQKVybbڮͯW|)i>kwwr }09KiHo2_O͞}fy.IEk̺CJr:i0٣*nd^ ! } ִ0l98U:=Rt?!·*2VS1t7du7Ge~mfִrpK\L>FD؝,7ec)c >Wiu9"y"rMury@M wfҲOk[RZ5¶SX+.u^ѡ6UO*zo iM{"è+L{N2Sk|f2:fB}>M[P=~KiN(۹ٕ9Aw A|a\# I-FuJgHh7oi/ DF^4a:]Npâr]8VG' VsTe[`볉̀=OGx/屫|9 8ɿUB?-@l AϫkY.'L/܁!EK㷏Wx3m[W-g< 8΁Bl'̠|Xi [%@ KSˮ=\=/g"̟"gv+Ju0>X,+={q+@hD@A)ĥoBH ;K+E2x4fT3,PuBU 9B%IԱw-F7oL4) 򽑿)DXQЄJC6_1,$ j=C(!{= $^}$_8AR™W 2Ӊ(; 9diV9. X_ek^&L*Q҇-z9N0'D W;)]*7P").,I lSRB qR-m] 9حB1خ(pnzWCshn467V, 73pCNQvaēT<7Pvitȅxw"Â̡`rJ- {XǵVł")(ozTDұ8݅uBvϷZnlu9L 䡈vY{ },e2 J#$-F<*>JHrƹh9( caT@`*z+8IqKI@T8lsmSTq WVYu r?i*Yag z$VFqǟUeG,|;ū4ÏoeW_5T+'M&M]1nVJB%yV/{U~xBlo3S T5QISE85%r`mt1 >@R ,w\Ko3ڸ)DBDQUG\=E/4 {g=9]PDȸǗ)j u d~:uxIQew9V$+6I%m;g=3i"0<z.bFܲO5U$D )Q)^u%"* (8!qX') ȍs a$"5ln~Z mi{[N F#K-rVr.pYAn#x}bnMБYv^JbtG.p6HmPG|/eeYHQpHM%[qg8uoWY\A^3C(ϏX)_%EeÄ%#T "}v^Es*|I$,0!Rf'I\Q##Bnu,0iCЌP3!bv&LO̒Ɠn7t@a\x>u9,` y?JEjbݨ{UˏQc>["14Rxɞ ~lz8Ǵݲnotn.*[ܡ[SeW9t E_>e%s&Jvs9w @&F]g P-V 4% -nCF.,mC@FX%cNMHPukZa "- ڒ#3e9 M-X䣙':)0qZ+<P[[ r#¨T￟; uҍ__ldn ҵ2's:g&rV}RSxmKEJ6?++]$ϛW+Qf^$6e64s5_٘"R#o=e7l Fty*WoaMc35~Ϭ b%dN۹Ir endstream endobj 83 0 obj<>stream %!FontType1-1.0: BPEJDB+Frutiger-Italic 1 13 dict begin /FontName /BPEJDB+Frutiger-Italic def /FontType 1 def /FontBBox {-169 -250 1091 930} readonly def /FontMatrix [0.001 0 0 0.001 0 0] readonly def /PaintType 0 def /FontInfo 12 dict dup begin /version (001.001) readonly def /Notice (Copyright (c) 1988, 1990 Adobe Systems Incorporated. All Rights Reserved.Frutiger is a registered trademark of Linotype AG and/or its subsidiaries.) readonly def /FullName (Frutiger 56 Italic) readonly def /FamilyName (Frutiger) readonly def /ItalicAngle -12 def /isFixedPitch false def /UnderlinePosition -100 def /UnderlineThickness 50 def /Weight (Roman) def /BaseFontName (Frutiger-Italic) def end def /Encoding StandardEncoding def currentdict end currentfile eexec O03, `$CnkXO%rX}9 ;󽽍WmOQW~_j`&hYօuVxam,s8YwNvsyCJQt1.]Fna}hCx$1IwT1zyzZYXq C[fD=7v&W:K Vn=!0ڶHH2#5= RHU:}]]R%@; 0K@0huj:<]c\UXbj2JjfCh>u*M٤8LECAeE/q&O㙲5AٔNI̊,Xn$ m]y,\⎠o< cQ~Oed5Ӧ2ԄT-z!2_ l{O#bs rOP2MصޤQ ;QIOA2}<)CAi>پT#VGdBF[Uip⨽YC&C(fMFvđN͂YE%[:A,@T/gZ8MUv zzІB/cRl):)K?;ljوE>J /^&?Yڔ:5{'4`GDWDqӚ&p]@y$U`F^I`R5X˕k\*(E⨙'ո`զdK͹z xbfDv _uy7!su^GԏMdc2b$5IU.~ SFn9Au~ddƇC<0n;@UyynWG]|:q<H3>2*]Ҝd7GO^x.oA{v!I>]vl4cxH& 퓚)q뜧hz'Kz1+:i&_| we\pY+YzD$o ʝ`kIKJ= m IT9}/VJsjLyE(hЍk9N."G&lCLvU{4zKxLim>.UN0@Ēp :@e?P]ƺErΎg@ml>vҝ]q}Hv ?7atxr獒`ӢE!s܇{ă(Sϋ^uƞx0G,=],/7l+22=NN|%w(11ga?~ b]~=Gcpjɶy6A4Jb~wa‡ b(MvwxG>7 E$D$kV)]+_$%nbVU>囼'⩺3ȴ퇲Գ"𷴡ɓմڰ1,.uޭ< Xd)Y0dٹN^S>5vU |N0U,_ ju%^r{}M19?銪Qy}!B65Rz?n#&NJlIPXS7'  \F$zBʌ]lˎ~u.&=Ƶӳ氱E޳.>l-5ԭф2?ĩ\J-ij|&"c3I6mFC؜ráV8BgBSHr,O7mwнlg-gW2ӻ HRO*NV~MW2=<Ċ(ɬ ̑(AamkClWBrU%}cc]$)Onj:Wx\۲TPVse_LPVm(k}G =͟Ϯ$B2>lBo@z)' M`tjsҭu_sM L6 'I=#R )*ӘT_/P yEd V[}$dnd-gX\2VcHEPehpps&=oF HXӌx]A[W?/;n.۷>VK {6]goP{*!{:A3l%\=c!],HG/(h_BOQU 6ՂD?>bˢZڰ0wUTݔ6V?x) 몔6{H9({#9D|.0nzжsX>P(]1HX"O4( ϯbUD. R.3rwowõ3ɐ3= iaR%;m``\c(s6ތ!Q4ȑ?pFn="9H>_cvJ9wx/fWo:-8Q38%ۅ+YGtm#A60\IhZD[oٖsG{LNb;L$MHHωx/-^ wX03<x)8|Dj{PbԤ@ )4㐗M sLI|[c4ݦP~[J,%SdA\5꩸@?Wpixf?݋aK`Xq$ &ʅMPD5 ư-3Wo3F&Il9P66Ԅ)&֞ܣL]4|ȚɀUm%?0 ,k4̐ʵ7fC #6[㿆OHqù.jUdnUc B"2` [^p!Jmƣ^ Pw=) ruCǜkdhĩ_M([tܷz 1㛪:tD_(c6hJ#ri+WR-XP(7۰s_ e_WoTMvj)S.Qޖ)1lT.^5Qj˼hR\Hi Jp7t{nѥ[0Cn15R[|EU^y#ɂk3b7`.+=Us8o:NP JW$$ !]xۈG7.T70?@z8#4#P0RYd%ED9}/qJM0?b,ŜP@\\.94-y#b%*.ə !ůlϚ 둲.;j>-9ݍ5;,ܾZϱŹ˭6T<ӧ*sqTm! \wpCԐ ;t=B!m^=RZۈRrd}5 `5YɅ?b1lZ +`@8iFB'&Ӯ`(v*2 &f\&g$`!eZhܨ݋TA+e}͝@U]ͣ#aG,M`etpcu~=  LjuTG50*aRx 7n<$\q/̊{mV+*v Ս2l8.܆8ڍ8Wjt|/PKU"C1UC5}e`bZ.AxPn!.CmJ%{K]D2/pSYz yLKLm]xm->Y׬1Sߐ?(䦬m@%Aۄ3Aโ$;;щk)<2%~sV/5(4I< 0Pb0~zkJpsǟ( 3;Sf%61ᡕprD^ePs"9 @;5*h BsdNb~u)'Yz^=X4? T>stream %!FontType1-1.0: BPEJHJ+FrizQuadrata-Bold 1 13 dict begin /FontName /BPEJHJ+FrizQuadrata-Bold def /FontType 1 def /FontBBox {-129 -250 1155 879} readonly def /FontMatrix [0.001 0 0 0.001 0 0] readonly def /PaintType 0 def /FontInfo 12 dict dup begin /version (001.003) readonly def /Notice (Copyright (c) 1985, 1987, 1990, 1994 Adobe Systems Incorporated. All Rights Reserved.) readonly def /FullName (Friz Quadrata Bold) readonly def /FamilyName (Friz Quadrata) readonly def /ItalicAngle 0 def /isFixedPitch false def /UnderlinePosition -100 def /UnderlineThickness 50 def /Weight (Bold) def /BaseFontName (FrizQuadrata-Bold) def end def /Encoding StandardEncoding def currentdict end currentfile eexec dMS|mxfpOhS.JMflRE},!h G3jTv]_O1:5˹б72@M 3?ٕhq+vH c/5YuҦB{@ &U1;Yk{kLb)}1Cⱇ&.q(/@Z H,1^Y@)E}>JUJQ5g(0?:ʭI( l- L2zUA+_[-V{yGpӺgՙͶ %ԀR15LW aXdRؤn=!wx[+ՆEQv0!ď@i[~fH^(nQ64u|aʭZ&d6TjPT_eJ"\.,ʇ CeZnf^TIP7biWxvْ1,aK÷ط3N#hտ{2 uu󙈮j0~&}$ou}h1YwH!UŒJ5OSکk%,w4.*2roj-"UM)̟͗X,E*9:;zն;:~Ħ-ۂxE {ÎmْͥA:&.>Z-u LEkVHAF2Z<=3Чg_.R͔Rf]Z@8rXLb/mP F;*  39"7.٬!<9d&cG%)zj% Im[rM,0S7[EB> @p:CwWk"}.b& r>xI0L: $mp|]oTU}-ф{~?kL*ʀx8Bx~8x,~d4ɾk PF@X^)U %4гMLW5}e.GwAd-ˊG6${ͬbs'VhTT(KDh=YKjHCW.q<y ?j!i"O#jv| 䕆y#FKRqaɼǾ]sX\S:[ l@Q*" xÿ*>n.n([kƆ({gFoDєD]&U#zbr+-5fF/֋)qp ,;ӫ~&ac`sh?I4 .3ia6-o0< ˣ'< \k$$>-g,FP߿.zeUo B9ixǓ>@(|ԱꮿٳLʇ2+#0ֳ=Aұʪ(&|l)9xc<@J"mWU]]1Z{ʯ>Iz6~s32N2asѓc(S@- HU$5 (LR]R/((‚,1x{[2MѹXkJ>Glò|?b# uن&pv%]G>b LWO>F _>VrG&G>D+ظDsokfM,t\ 'QD;;cRևdX9`_06F'#=v`FM[0??Rtޗ]?thba;/$g"uʇ鬒(dp5$ 'P ݳuV&s O` tȋ?`NcuzƻYd *o׶|V@=/V\#`EFSb޽v֘Go̦I,JVtup=C|oP_2e+t8cN_q`px,& \MhM>ZAT(]P te}S( |hB)U/d[F(PÎ5I}柴 ]h<9aqgyvT¼}>Cwɀ!s%Ƭ :س~ZgjԞM9^;m%4o ,(PZ?]k{$2`*s ۀ;Yhf9Ї1Ip p[fнl~:54@6h!y+$J}LJtpٸ]_|MuAU{X]?@]ʮ?h uJO$VEF.%gGHgHw߅oTR ĩ ;-XSuov:?FDZ,vlJ~%_j60 9{DCzmq\^yS x@(BCc6b#:XwJ+91 0&B+E D!el0WҾ(;@d[ .fw6(W |}hH+XRtel ؁iyyǩdJ*Ԝb07W$NS%0k%[M< F 6t+W:ABiQaXr E;$' S2DSfEihs엯k;rp, ?n4 _f[Ak979d ٨ -<>{K\餗^ #5.MxqM.s5pHصk9_HhmW"o̗'n# 6.`VVf"{g{IZT4Q!РF1,|q`_Ym#G"EmkGR@=V\tzq{9|C]a顕Aƌ' 4xhm:{Q"c}<ЌO#-'2w2 /Q;|xttVZҠЗkq&Zj0Bc)۹Q?IBb & p V7Ap'9CH8d-PC0 ,ʙ´#A 0le%ڦhNlh`[cpl αlSw̷bh"dEl\:a>>'<<(-@VhH ̴lYMHϺ"Q a SRi]td%SM`#"˯ݵHuӯLjRԒ/Oc5oz K4cVn`^0a<,+!LFYt10ڢg3EsY_x؏F^mU0ܶVES:v2"'\?L{Xv{_Vj'K fb/_,moլ K \?5L4 >);>փdHvJM;#[!Lqeݬ]gBc !s8Uk?O B04$ny˓/4jЧ U8(%*VE݊. \E endstream endobj 85 0 obj<>stream %!FontType1-1.0: Optima 1 13 dict begin /FontName /Optima def /FontType 1 def /FontBBox {-78 -271 1000 919} readonly def /FontMatrix [0.001 0 0 0.001 0 0] readonly def /PaintType 0 def /FontInfo 12 dict dup begin /version (001.001) readonly def /Notice (Optima is a trademark of Allied Corporation.) readonly def /FullName (Optima) readonly def /FamilyName (Optima) readonly def /ItalicAngle 0 def /isFixedPitch false def /UnderlinePosition -141 def /UnderlineThickness 38 def /Weight (Roman) def /BaseFontName (Optima) def end def /Encoding StandardEncoding def currentdict end currentfile eexec zlZ"I;(Iwp=&^5NkG"?Wր|r)Indj Z, L: $XeFc ,[Z]XIg9qc[仕\*9ۢ F˅׎ XѬsb+P'-hpv@,^2CMULgÀw*3u燸溦dxwHn2)#g5Mmhki(&5wEĹDK{KK"Qhck"Zo|Ƚތ}P,4aBRz]ކ9r }!XLj'k3rQģ1=\U lF8uraFJW 显6dF(!fL$iKSŹ Mj~`7vĂ{&3z 5_ϯhYdתP[2Ra gYs׊+ /Z/@oS9 R Z;ԡKd@XKn[bsDY1J\Iݞqjc(r:Y ͖bY4SDqeܗ {#PId3> oWi3+FЁЛC% \mES 2!`Њ|ʔ1p, bq#pV'_*Bjė?ƱopoH74_M2CJ4bLwiw:Ȏ|UI]Cb YOv綣JBUߧQ)  щLmk` ؆5Dw~&Pْ{yKOGѨ_(U/'_4g&h؃fG8}g$5>IS3K;2V1jΧb_Om*xK)rw-'6j[_F b^ UTtkhSn¥> Q jX.ɘ@{2a1R22"dOJN;TerkpzS>^TJC+ѺS>*TPQ7 }#<3SEFٵąI޻[0Q8fc4%EWj,M:|M5؉(4?ȁ7uc:Ab0`\,-R^Lp@j<=0ʗ3OEGhĬaXvȹV[.+ ә5s=A X|ͯr??ޣUZ!.Դ",bM7i/%$7sDm v|eka3ND Y Ѧ͞hmVR+ r0m=uK A N&v;N1MC*T?qΔ:'[CO_Dx UH7%o r߁ pη3Ŵ3z%q[qo?Xy_D[HJXҸQd cw=#,-$υ23[ wknEEe~s"A6jb<>]L!GNS~FJDgrc'Cmy: nu!=]eְNȌܛmVoB=djZ 1vD0\_ /\*"+38癓¬Iq^ ͘ EgAKg=sqvWI1 O}^[顫)d+rJtmaFgX"t幙`( !%mѩW>@Hj$Mӂtu'}S }eY6N?uc|WJP &p|I'Xe߸ދDRշOb],]KkZ`?v·@9k.6J%|[~,+6E kf^B;C/k\?BBlq;wߛj&O#Em6tlz$>zp j| b`// {j3BlcMᎬGꅾm$%R>q84Qڥ!!Ǔf=n;3a䳦PʭvXalVXzF `-Y(?v UAa5`x*uu%sk-nybWN<#@Z`B4B*_~m wߩҢ{]? 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ƝIHyM[ gb>N;Ѱ=*nu#/jGNA&v"pK9kndئfzw}8EwBҪ}OVFWGLZ=y&E,kf"j bz~ȨEMYE"[_LnDY`0NﲡFM[$K?B˿WN -AE rO`ž1 ##aFאc/^n0xMv瞮?JΫuz1 v9QcGr\46o`<yyLfb{坍 A=C.yR@@z綔<`)?Tg%)M-j8~"¿ 7iR}‹ӧ3B8A6!z=oM62v.>tYkTT\쑯]l X&B]`C8Ȕ@,&6A@|vԌ77$Lj.J~P{{, ͻ=c(EbShⳠL BX؍>VPIJ󲵪><-\#)>,&-+r0E_8`,Zy! o J;VW.1[Jg+#ڟLR2c'CUKbf.=t>4lthDM-g+t 8>m[.˄xD9DlLA1B_kz&8Ѯb5:L뻉~|Z F; %͜0wi'ӫJyPBZB==]* kG~ endstream endobj 86 0 obj<>stream %!FontType1-1.0: BPEFJL+FrizQuadrata 1 13 dict begin /FontName /BPEFJL+FrizQuadrata def /FontType 1 def /FontBBox {-147 -250 1138 884} readonly def /FontMatrix [0.001 0 0 0.001 0 0] readonly def /PaintType 0 def /FontInfo 12 dict dup begin /version (001.003) readonly def /Notice (Copyright (c) 1985, 1987, 1990, 1994 Adobe Systems Incorporated. All Rights Reserved.) readonly def /FullName (Friz Quadrata) readonly def /FamilyName (Friz Quadrata) readonly def /ItalicAngle 0 def /isFixedPitch false def /UnderlinePosition -100 def /UnderlineThickness 50 def /Weight (Medium) def /BaseFontName (FrizQuadrata) def end def /Encoding StandardEncoding def currentdict end currentfile eexec K"|Q& S$PnyZ>OubJLY+JhP&5 1Q-aEkMJ!Gĉ{nIe"^􊉔߽ I(Z/[\.Qk=r1{v݅67/\jc/ռg/? \cK\ܧA}-zQ!9I@?_& Zsj=iDLXd&pk,-YZm;'DjP@,IY{eSNA3qzڶQ#PIRURF)ġSꟙ?]Ҋhs֟! w~PX?re4/\⌰6L|&#O6XBж޷] MnOqMH: .GwO9Tp]/i% Bi#%ccGCb LN.fPu>EJlzKM}ϯyDLT݀zx5$_>Gֲ x[L3As|{D&'ju+ `ȿB58V,1տn,( FϘ4&۱%)xn>1H)Qٿ2K\Ц boɾvY/yarhmڭfP`.CEĊo퍮NnC@~YI}sN=e '_bl[N حSr] ȩ$`-.@ 'tϴ#<Sd?~} m+!T~*:/r,Ehͯu˱ɧ==U c$V~ lgf?uBS=2RE KX?pp /fW肚K]Y} 3nwޜvTZ"&8/C:ҴxU(H߱X]n00'/6 'PވFZ]H-br$싅h\pF8XozR)ξXِbq ^JH1y5kGqq(xf7Js%pط[Lҹ.ٮd( C9ge<* CƥzN>9SLCXEohj,)>I4DXcQvHZ?NM*(4{Igq9dߛ@mh W؏!}\FVtup=C|oTX?_GS'Pa=+Q=GwSW'̎`@קLjhR<&&n0Wx6]r]`A bbߋS@dDf+l07s1\!M5$ '2b3 )X5*E- lX,'M'/&M.E5!d z&okrz*w$$ E`P_-}.83尭K0Oé iW5T &G'_V,쀵K X?GwG,ŀj d(Yƒ/qEfMu-Q!\;YEPfՂN2'Pms 2@ENAx'VJֿDLJnUrd! j|fZ P7Əy@z(|Haѯe.B,cv?S <4oװsS e"9]攛 b#Q8 ogJ3h;m=V^5}QG4u7$73]$C\mzqy3ĤxN9Q- 6iSa<[-Dwݢf|9z?&3鑩tFpt{Li 7Gv*}Lc;jɄW|`aE8sLos$x.0jMn*gugCڄZ;Lԧ7Sv7Chég2^Cf/Q!1g.0{קܶAC/p00LlsK CR2 Io"$P:?h =g>&L!ք8p˭#`P.H3PQ8 !KOV *dyX+Za/qTNKͬI,'È!U@ 3wXGZ]ۗ4$V@; 5;>1rs#rV[ubŻyk^;pBDm8'Oq2&>(0C(ji$$l+tF\dzO|ldVHL '(J\*l=u:82CTIy*%Ayr8O$$ӧX'LƼj4/Rku;~T9lhC50;6._nh4Q^ߵ_$?Q!Ԯ")[+rs\ha+1Lw&uO %T-uI,f;vb*%JӍ!_jU ۟xLV]@LnqoΆ.xi٨.gd+5}"wΥW֮ cAjv?^$J$%ބ8$R)Ĺt?.*ǧ9UoFge cZ;guZZJ;ݦ, Ud^kՊ_;uD{Y|3ǫA_$P| ;uضj׎Agx,+ZRXNNax/RvF'>FTUeدrvXJM:_>tE4 D=kʨn9\d* URGhwr"lHe( Sֳ͂P}`F`dXڿ)n(~wB0GnKs{Zh߷hw £Y%)"5ea>oc&G@(@Ȧ`^D8 *4Y 1gQouo "B0͏wOވ>OЌs 󎕡f23>AvcZe @ugn/^>}͗aČ,1ђv2fְ P ʇXFp Ja3amOg`z,dEx"tR"z?D.R02{L#Zb ^:žDSv 4 }dYhբMcq -iHLINӫ)5[\n~e Kor [i?D5M %$)Zٳ~ 8hHMcS?/^K l%|kR귈/my=lY9*Vc1d=0\3{\(DԈ'aJ)#w?&7"N׿ :%m,5nk\qGsNLecJK tP cfŔ-(dhQ *HUf[x>sB/CXT[f^7D9K@~Jٟ j! {9џSi .#XW?-ӈpPo#Fn\Ӕ(죘9 $ۑ8ѯmSs,nsU, Xހwkx}aE/g/ m$7CĊXpnL51n=zW]!$>T2Wbz3 'LQ; љ+X|rS ߱lugnOh[ݩ`ߍ4p9 苛Ya%n]7QuZ!, xs/q'Rp}aγ7n_W`0`Xqh lh8m~N$֞@*9 x"#8soXstGw{DL^%W>ab'Z#Bxp#ȅ_luBU_^q*h;ns I<#\c3;nqeVD/{BЄlr DEʭ5Ds8vW?\X6)(4c\Lra>QYprVoCB,䟡4 $!2LIG>]?L$/jfЯAX# E 5lZ(c|pV&Op{^7tֱ_S\Љ"9ZGwkT-ɲx߲Z\A-`eAv /kZ≉ ;[n;*^gd@6(W]9s#Q 2?}aV*WmI| _ĥ2&49z6K9s>*C0B+iN1Nn;#]`ٟMD V&;0+ NrԼkԺ mh'-ڼC8gDQfF:1ZiD`n-E яGD]&0'@ҡg0&IA`ĺ =&>t>N8~z,-]Z|&_#kd~MbbXH3k6 Կ^.'%almÀMbձ[#<9vA-?fLX]g1oܙ*OSo/@>6/5f1Q.N|a\ P/Ԁ_f{cp,Pټ{f)-FfʧݟCTq̻gΨ?xȻ{ig+\PdԎjLO}:Nl۪'coO6< !UڛVAp0sbKsKi@I m *O˳ 䠛NŃl292SZ),ԔEPiIC]6G#MǗHz(9|/lҦIzo )3? wq4> endobj 88 0 obj<>stream %!FontType1-1.0: BPEGGD+Garamond-LightCondensed 1 13 dict begin /FontName /BPEGGD+Garamond-LightCondensed def /FontType 1 def /FontBBox {-167 -232 1000 857} readonly def /FontMatrix [0.001 0 0 0.001 0 0] readonly def /PaintType 0 def /FontInfo 12 dict dup begin /version (001.000) readonly def /Notice (Copyright (c) 1990 Adobe Systems Incorporated. All Rights Reserved.ITC Garamond is a registered trademark of International Typeface Corporation.) readonly def /FullName (ITC Garamond Light Condensed) readonly def /FamilyName (ITC Garamond) readonly def /ItalicAngle 0 def /isFixedPitch false def /UnderlinePosition -100 def /UnderlineThickness 50 def /Weight (Light) def /BaseFontName (Garamond-LightCondensed) def end def /Encoding StandardEncoding def currentdict end currentfile eexec =2MݏAnN:}`- 0KF޾0㇧ h`$L-s9}MՇ߶Rx+ 6ʁ=qw+ܴ;5)N6Q] {"jݚqW*~073 WCN 0%ㄿP }jϹy {IG/W Eҿݫ8kB/ QFEnxUڕHdU &;]ӈCQTD7(tTH0HAYȫsA{}`Vɼ=6̻+J J] hPhI"V93H_֍iHqӝNTv-YN ԡdYNPYTln)TIRB ΦHœ 1TI@oZ n4.pa͔ϢTdZ,? }ƣ+_Mǽ=6mJkmHU:Rؒ*)=Y'1yCZs x~P#/DadEJ:o=E+n# =ɿ]b$N|p~.X< RdDͪf6.&p| =6mveP7:f/DPeЇӔrjә}L.1YA1Ap-`HmXh/}Zu*A),J`Z ]*[Q&fiGĸ8%Gti]k0B!W6nvډޟV&v䏴E/;g}_Jq }>!p)<-]EjT[h^ۆyH0=š ]@f)vyN.VJ]" B4R9FT4Y:w%L ѣEv~/h%d9-3XRPhI!]mr}txU7 xd6XXtW5Ug"Tq)r~2Qb*eM:-ݽn&Om?MQXI{s!1B0<4=0čq> Y~Ҧ _qy g~٭BBuffp@dR~+}THAeSmﲁ=.̅/NzSC Ez%fxNg6)Wf-GD|6\;|;)r)QfnYrSk}K?2cF.\xңvd3E-s*tk\.ImPwҕ뾂eh)B~ESX옹Dl%dhqW&m25g7-^i|F$s[IU1k{? 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}Emdk8lb-@ OHѹJsQkT?3;K/,VGcǼwXw76 Bq0$ K)Ae,NV1t1س_ ֻn_(>ԍ7䭵9>=)Y7LgZi-U~HE~K+^;*3_mOр6Q SP Ƭ-Y֤vA[ƇIN̨2{'/ whr]wX߆n$^SIͶ62E6O?eXUmW;cZVYY24$Vmx"S{N(h5&6&`6'MPE@؄p#YWGxtbU^(wv*dHK'EZʵ5^^ZCjP(m{v%-IpzE!΍ትedcŗn1ʼ{HaX?a@-4`)bDpGJz Qyw.U\ d0nގXD]b:>QiO 9W$`*(OzdQ'"j%$3Sp.0 1McF:(bڂHXbS4˼:J%B".n!F9qd4y(:ˊzEM/`Xs8'b59mv U4 VF#ܡAǦ$`hll<sePE6)׫zxwS $bpʄ@[h5Z=Kty&h M}pFG̒?e [᪱l"Ӂ>:2xų7'⳦#ಳ-ɽ][ױ֭?թ5ı7;Cܰ02?߰h,<fD; 3u v}Vo/ƂW"=eDHwRQB$ۑp6&A|$qq4F]>&]u=Hk Gr#w`ڱds˖m4t^Å4,`|de rJK({s8(SO/ǧCyG grf .or4W]Z˭0hS`N,]3j 9լ(P De42 V>H6ށD5#adg8I6lA S6~Pe:+^TKq#4 p% ɧP3gr, m_,^r-F@x -A(iC$Yuj meލTÕoY; =r '/5f&"$2r:PLaBu+0 V}ڱN2#hyK\h +ReٟpX>X|I1͘,ҠǨF3t*S'T |ZdpP57^~/uyKz ;s^勞(Cb!0S!TQ[L.n"7'DcL S>2nƻ.s14~O0'/A-½<6{ hJDa.x^l_% OuLa:|FPgߴ~Cxd?_)nH GԍT12r2 endstream endobj 89 0 obj<> endobj 1 0 obj<> endobj 2 0 obj<>/ProcSet[/PDF/Text]/ExtGState<>>> endobj 3 0 obj<>stream 0 0 0 1 k BX /GS2 gs EX 1 i 288.04 -22.076 35.921 83.815 re f BT /F14 1 Tf 9.978 0 0 9.978 72.516 712.8 Tm 0 Tc 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[(ecules,)-615(and)-615(cytoskeletal)-615(protein\320the)-615(necessary)]TJ T* [(components)-813.9(of)-813.9(long-term)-813.9(plasticity)-813.9(\()-100(learning\))]TJ T* (changes.)Tj 1.8 -1.2 TD [(From)-289.7(this)-289.8(sequence)-289.7(it)-289.8(follows)-289.8(that)-289.8(if)-289.8(CREB)-289.7(has)]TJ -1.8 -1.2 TD [(a)-417.6(critical)-417.6(role)-417.6(in)-417.6(initiating)-417.6(the)-417.6(genomic)-417.6(transcrip-)]TJ T* [(tion)-631.2(underlying)-631.2(long-term)-631.2(memory,)-631.2(then)-631.2(CREB)]TJ T* [(phosphorylation)-297.7(should)-297.7(be)-297.7(an)-297.7(early)-297.7(step)-297.7(in)-297.7(the)-297.7(de-)]TJ T* [(velopment)-459.9(of)-459.9(long-term)-459.9(memories.)-459.9(Translocation)]TJ T* [(of)-477.8(a)-477.8(protein)-477.8(kinase)-477.8(A)-477.8(subunit)-477.8(to)-477.8(the)-477.8(nucleus)-477.8(of)]TJ /F17 1 Tf T* (Aplysia)Tj /F14 1 Tf 3.4634 0 TD [(sensory)-250.5(neurons)-250.5(following)-250.5(serotonin)-250.5(appli-)]TJ -3.4634 -1.2 TD 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73.1594 606.7656 cm BI /W 447 /H 1 /BPC 4 /CS /DeviceGray ID EI Q q 214.56 0 0 0.24 73.1594 606.5256 cm BI /W 447 /H 1 /BPC 4 /CS /DeviceGray ID EI Q q 214.56 0 0 0.24 73.1594 606.2856 cm BI /W 447 /H 1 /BPC 4 /CS /DeviceGray ID EI Q q 214.56 0 0 0.24 73.1594 606.0457 cm BI /W 447 /H 1 /BPC 4 /CS /DeviceGray ID nZ EI Q q 214.56 0 0 0.24 73.1594 605.8057 cm BI /W 447 /H 1 /BPC 4 /CS /DeviceGray ID uq 0 @  EI Q q 214.56 0 0 0.24 73.1594 605.5657 cm BI /W 447 /H 1 /BPC 4 /CS /DeviceGray ID `Po p0 EI Q q 214.56 0 0 0.24 73.1594 605.3256 cm BI /W 447 /H 1 /BPC 4 /CS /DeviceGray ID  P@ EI Q q 214.56 0 0 0.24 73.1594 605.0856 cm BI /W 447 /H 1 /BPC 4 /CS /DeviceGray ID "  ?  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9.978 170.452 396.479 Tm (,)Tj /F17 1 Tf 0.5374 0 TD (P)Tj /F14 1 Tf 0.8467 0 TD [(<)-264.7(0.05\))-272.4(and)-272.4(Naive)-272.4(group)]TJ -11.1994 -1.2 TD [(\(avg)-264.7(=)-264.7(1.2)-465.3(cells)-59.9(/)-59.9(10,000)-465.3(\177m)]TJ 7.483 0 0 6.486 190.86 388.746 Tm (2)Tj 9.978 0 0 9.978 194.826 384.505 Tm (,)Tj /F17 1 Tf 0.7303 0 TD (P)Tj /F14 1 Tf 0.8467 0 TD [(<)-264.7(0.05\))-465.3(while)-465.3(the)]TJ -13.8351 -1.2 TD [(Odor)-279.2(only)-279.2(group)-279.2(\(avg)-264.7(=)-264.7(1.1)-279.2(cells)-59.9(/)-59.9(10,000)-279.2(\177m)]TJ 7.483 0 0 6.486 261.367 376.773 Tm (2)Tj 9.978 0 0 9.978 265.333 372.532 Tm [(\))-279.2(was)]TJ -19.3243 -1.2 TD [(not)-332.9(significant.)]TJ /F16 1 Tf 11.974 0 0 11.974 72.516 324.388 Tm (Discussion)Tj /F14 1 Tf 9.978 0 0 9.978 90.476 305.929 Tm [(The)-327.5(significantly)-327.5(greater)-327.5(increase)-327.5(in)-327.5(pCREB)-327.5(in)]TJ -1.8 -1.2 TD [(the)-228.7(olfactory)-228.7(bulb)-228.7(of)-228.7(rat)-228.7(pups)-228.7(undergoing)-228.7(a)-228.7(training)]TJ T* [(procedure)-367(known)-367(to)-367(produce)-367(a)-367(conditioned)-367(pref-)]TJ T* [(erence)-260.2(for)-260.2(peppermint)-260.2(odor)-260.2(24)-260.2(hr)-260.2(later)-260.2(\(McLean)-260.2(et)]TJ T* [(al.)-444(1993;)-444(Langdon)-444(et)-444(al.)-444(1997;)-444(Price)-444(et)-444(al.)-444(1998\))]TJ T* [(supports)-422.7(the)-422.7(hypothesis)-422.7(that)-422.7(CREB)-422.7(is)-422.7(a)-422.7(universal)]TJ T* [(memory)-467.3(molecule)-467.3(implicated)-467.3(in)-467.3(the)-467.3(initiation)-467.3(of)]TJ T* [(long-term)-472.1(memories.)-472.1(Neither)-472.1(Odor)-472.1(alone,)-472.1(which)]TJ T* [(can)-340.3(increase)-340.3(c-fos)-340.3(expression)-340.3(in)-340.3(similar)-340.3(regions)-340.3(of)]TJ T* [(the)-673.3(olfactory)-673.3(bulb)-673.3(\(Guthrie)-673.3(and)-673.3(Gall)-673.3(1995a,b;)]TJ T* [(Johnson)-332.1(et)-332.1(al.)-332.1(1995\),)-332.1(nor)-332.1(Stroking)-332.1(alone,)-332.1(which)-332.1(is)]TJ T* [(known)-272.7(to)-272.7(activate)-272.7(noradrenergic)-272.7(neurons)-272.7(involved)]TJ T* [(in)-457.4(modulating)-457.4(pCREB)-457.4(levels)-457.4(\(Cirelli)-457.4(et)-457.4(al.)-457.4(1996\),)]TJ T* [(was)-567.6(able)-567.6(to)-567.6(produce)-567.6(a)-567.6(comparable)-567.6(increase)-567.6(in)]TJ T* [(CREB)-414.7(phosphorylation.)-414.8(In)-414.7(initial)-414.8(experiments)-414.8(we)]TJ T* [(also)-528.9(observed)-528.9(that)-529(the)-529(olfactory)-529(bulbs)-529(of)-529(Naive)]TJ T* [(pups)-256.8(exhibited)-256.8(relatively)-256.8(low)-256.8(levels)-256.8(of)-256.8(pCREB)-256.8(\()-100(Fig.)]TJ T* [(2\).)-390.3(Low)-390.3(levels)-390.3(of)-390.3(pCREB)-390.3(were)-390.3(quantitated)-390.3(by)-390.3(im-)]TJ T* [(munocytochemistry)-276.7(in)-276.7(the)-276.7(bulbs)-276.7(of)-276.7(Naive)-276.7(pups,)-276.7(an)]TJ 25.2 33.075 TD [(observation)-348.3(which)-348.3(was)-348.3(in)-348.3(keeping)-348.3(with)-348.3(the)-348.3(quali-)]TJ 0 -1.2 TD [(tative)-225.5(observations)-225.5(in)-225.5(Western)-225.5(blots.)-225.6(Thus,)-225.6(baseline)]TJ T* [(levels)-402(of)-402(pCREB)-402(were)-402(observed)-402(in)-402(Naive)-402(pups)-402(as)]TJ T* [(well)-276.4(as)-276.4(pups)-276.4(given)-276.4(nonlearning)-276.4(training.)-276.4(The)-276.4(quali-)]TJ T* [(tative)-360.8(and)-360.8(quantitative)-360.8(data)-360.8(suggest)-360.8(that)-360.8(pCREB)-360.8(is)]TJ T* [(increased)-460.2(only)-460.2(when)-460.2(pups)-460.2(are)-460.2(trained)-460.2(by)-460.2(condi-)]TJ T* [(tioning.)-366.7(This)-366.7(is)-366.7(consistent)-366.7(with)-366.7(a)-366.7(model)-366.7(in)-366.7(which)]TJ T* [(both)-405.4(a)-405.4(calcium)-405.3(signal)-405.4(initiated)-405.4(by)-405.4(the)-405.4(odor)-405.4(input)]TJ T* [(\()-100(Bozza)-417(and)-417(Kauer)-417(1998\))-417(and)-417(a)-417(cAMP)-417(signal)-417(initi-)]TJ T* [(ated)-233.8(by)-233.8(norepinephrine)-233.8(are)-233.8(required)-233.8(synergistically)]TJ T* [(to)-292.3(elevate)-292.3(significantly)-292.3(pCREB)-292.3(levels.)-292.3(While)-292.3(the)-292.3(se-)]TJ T* [(lectivity)-268.4(of)-268.4(the)-268.4(pCREB)-268.4(increase)-268.4(for)-268.4(the)-268.4(pairing)-268.4(con-)]TJ T* [(dition)-504.2(supports)-504.2(a)-504.2(special)-504.2(role)-504.2(of)-504.2(the)-504.2(CREB)-504.2(pro-)]TJ T* [(moter)-312.8(in)-312.8(associative)-312.8(learning,)-312.8(future)-312.8(investigations)]TJ T* [(should)-617.3(compare)-617.3(forward)-617.3(\(Odor)-264.8(+)-264.7(Stroking\))-617.3(and)]TJ T* [(backward)-451.1(\(Stroking)-451.1(followed)-451.1(by)-451.1(Odor,)-451.1(nonlearn-)]TJ T* [(ing\))-220.2(pairing.)-220.2(A)-220.1(demonstration)-220.1(of)-220.2(an)-220.1(effect)-220.2(of)-220.2(pairing)]TJ T* [(order,)-249.4(which)-249.4(is)-249.4(known)-249.4(to)-249.4(affect)-249.4(memory)-249.4(formation)]TJ T* [(in)-324.4(this)-324.4(paradigm)-324.4(\(McLean)-324.4(et)-324.4(al.)-324.4(1996;)-324.4(Sullivan)-324.4(and)]TJ T* [(Hall)-230.1(1988;)-230.1(Sullivan)-230.1(et)-230.1(al.)-230.1(1991;)-230.1(Sullivan)-230.1(et)-230.1(al.)-230.1(1989b;)]TJ T* [(Wilson)-616.7(and)-616.7(Sullivan)-616.7(1991\),)-616.7(would)-616.7(provide)-616.7(the)]TJ T* [(strongest)-294.9(test)-294.9(of)-294.9(the)-294.9(claim)-294.8(for)-294.9(a)-294.9(unique)-294.9(association)]TJ T* [(between)-283.8(pCREB)-283.8(increases)-283.8(and)-283.8(associative)-283.8(memory)]TJ T* (formation.)Tj 8.98 0 0 8.98 323.96 120.589 Tm [(TEMPORAL)-443.8(AND)-443.8(SPATIAL)-443.8(CHARACTERISTICS)]TJ 0 -1.3333 TD [(OF)-443.8(PCREB)-352.9(INCREASES)]TJ 9.978 0 0 9.978 341.921 90.156 Tm [(As)-633.5(predicted)-633.5(by)-633.5(the)-633.5(Frank)-633.5(and)-633.5(Greenberg)]TJ ET BX /GS3 gs EX q 284.64 0 0 0.16 72.5159 720.1257 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻ EI Q q 284.64 0 0 0.16 72.5159 719.9656 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ۫˻ EI Q q 284.64 0 0 0.16 72.5159 719.8056 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ۪̻˽ EI Q q 284.64 0 0 0.16 72.5159 719.6457 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ۪̻ EI Q q 284.64 0 0 0.16 72.5159 719.4857 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܫ EI Q q 284.64 0 0 0.16 72.5159 719.3256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ۻݻ EI Q q 284.64 0 0 0.16 72.5159 719.1656 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ۪ܼ EI Q q 284.64 0 0 0.16 72.5159 719.0057 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻ܻ EI Q q 284.64 0 0 0.16 72.5159 718.8456 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˫ܻܼ EI Q q 284.64 0 0 0.16 72.5159 718.6856 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܻܫۼ˻ EI Q q 284.64 0 0 0.16 72.5159 718.5256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܺܫ̻˼˻ EI Q q 284.64 0 0 0.16 72.5159 718.3657 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻ܻͻܼ˼̻ EI Q q 284.64 0 0 0.16 72.5159 718.2056 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻̼ܻ̻˼̻˻ʼ EI Q q 284.64 0 0 0.16 72.5159 718.0456 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻ܻ̻컼̻̻ʼ EI Q q 284.64 0 0 0.16 72.5159 717.8857 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻̻̻ܺ˻˼ EI Q q 284.64 0 0 0.16 72.5159 717.7256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˼̻ݼ˺۪˻̼ EI Q q 284.64 0 0 0.16 72.5159 717.5656 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˼ۻ˺̼۫˫ܻ EI Q q 284.64 0 0 0.16 72.5159 717.4056 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻ܺ˺̼ܻ˻ܼ̻ EI Q q 284.64 0 0 0.16 72.5159 717.2457 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻ܻ̻̼ܼ˻̻ EI Q q 284.64 0 0 0.16 72.5159 717.0856 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻˼˻˼ܼ˻ܼ EI Q q 284.64 0 0 0.16 72.5159 716.9257 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻˻˼̼ܼ EI Q q 284.64 0 0 0.16 72.5159 716.7657 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܼ˻̼ۻ̻̽˻˼ EI Q q 284.64 0 0 0.16 72.5159 716.6057 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID 3Ujܻ˼̼ܻ̼˻˪˻˻˼ܼ EI Q q 284.64 0 0 0.16 72.5159 716.4456 cm BI /W 593 /H 1 /BPC 4 /CS 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4 /CS /DeviceGray ID ʘ˻۪ܻۖ˺ܻw˻̧y˼˧Dg˻̻̩ʉ˻Vۚxܷy̻˫۪ʽܼ!,N EI Q q 284.64 0 0 0.16 72.5159 704.7657 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ʙܪʚܖۻ̻gܻʬf̻ܼx̼CW̺̻˪ʚ˹F˻˚˻ܷy˻˻ܻ˽ܼN EI Q q 284.64 0 0 0.16 72.5159 704.6057 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ʩܻʛ̗̺y̻wܻʬV˩̻̼BG˺˻˼ʚ˸E̻˪˻̦y˻˻ܻ˽ۼ1N EI Q q 284.64 0 0 0.16 72.5159 704.4456 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ʪʫ˺̨ܻzʻܼʼW̨̺˻BWy̺ݺ̨̻6̪̻̗̻˺̻˼ܻ˽N EI Q q 284.64 0 0 0.16 72.5159 704.2856 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ʩˬ˺ܼʬ˼˻h˙̻˫wSWy̺˻̺ܫ̩G˩z˩̧̻˻ܻʼq-1~N EI Q q 284.64 0 0 0.16 72.5159 704.1256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̺̼̺˻ۻʬۼݺ˺˩̻˻ffx˻˪̩ܪ̺X̹y˩˗̼̻˻̻̻Qnq^N EI Q q 284.64 0 0 0.16 72.5159 703.9656 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˺ܻ˻̼ۻɬ˼ݺ˚̻˩˻wvgݹ˩̻̼̩ܫ̺̼̺˩̻˻ͻ̼̻ͺ˻ܻ1>N EI Q q 284.64 0 0 0.16 72.5159 703.8057 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܼ˻̻̼ܽۺʬܻ̻̻̻̻ܺxugͷ̨˻̻̪̼ͫ˼̺f̩˻˻˻̺˼̺̻˻ܺ!غ#N EI Q q 284.64 0 0 0.16 72.5159 703.6456 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID 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EI Q q 284.64 0 0 0.16 72.5159 700.6057 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ݻܼܻݻ̻̻˼˪̸x̹f̻̻w˼˙˻˻̺˫{̼˺ix̻̼˻̻A>1> EI Q q 284.64 0 0 0.16 72.5159 700.4456 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˼ܼܻ̼˖ܼ˪˻̹̼tw̻̺˼˘˻̺˪{̼˻f̻̼̻˻˻*>AN EI Q q 284.64 0 0 0.16 72.5159 700.2856 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻̼̻˪̻̻cg˻˺˻˺˨̼̻̻˪g|˻g˻˼̻n~Q^ EI Q q 284.64 0 0 0.16 72.5159 700.1257 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̼ܻ˪̺̻ch̻̻x˻̹̼̻˙˪y̼˻̻̼˻Fa EI Q q 284.64 0 0 0.16 72.5159 699.9656 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܼܻ˻̻sh̺vݻ˻̼̼˻ˉt˚y̼˫ˊ̼̼˻˻˻a EI Q q 284.64 0 0 0.16 72.5159 699.8056 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˼̼ܺ˻˨̻i̺fy˻˼˻ˉ{ˉ̻˻̪̼˼̻˻˻a EI Q q 284.64 0 0 0.16 72.5159 699.6456 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܻʫܻ˼̻ʘ˻h̪̻fݻ˻˻̺˻˻̻{ʉ̻ʫ̻˼˻̻Q EI Q q 284.64 0 0 0.16 72.5159 699.4857 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܼ̻ʫ̼˪˺h˻̻vy̻˻̻˫˼˻z˻̼ʪ̻ܻ̻˼1 EI Q q 284.64 0 0 0.16 72.5159 699.3256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID 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72.5159 696.4456 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ݻ̽˻ܼ˪˻ʚʪ˻̻˻˻˼˻̻{V˻̻˫ۼ EI Q q 284.64 0 0 0.16 72.5159 696.2856 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ݼ̼˻ܼ˪˙ʫ̻̻۪˻˼̻˪ͻ˻ʚg˪˼̻˻˼ EI Q q 284.64 0 0 0.16 72.5159 696.1257 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˼̻ܼ˪̼˙˫˻˫˻̻̼̻̻۫˻˻˪ EI Q q 284.64 0 0 0.16 72.5159 695.9656 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̼̻̼̻۪̻˩˻̻ܻ̻˼˪˻̻˺y̻˺ EI Q q 284.64 0 0 0.16 72.5159 695.8057 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻̫̼̺˫̩˻̻ܻ˼˪˪˻̻̻X˻˺ EI Q q 284.64 0 0 0.16 72.5159 695.6456 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻ۼܼܻ̻˚˻̻̪˺˼̺˺̻̼˻̻˺˻G˩ EI Q q 284.64 0 0 0.16 72.5159 695.4857 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̼̻̻ܻ̽˼̻̻̻̪˼˻̼˻˻˻˫˻˪˺xV̻ EI Q q 284.64 0 0 0.16 72.5159 695.3256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܼ˻̼ܻܻ˻̻˼˻˩˼̻˻̻̼˫˻ͻ˫˻˻˻ʪ̺xyv̻y EI Q q 284.64 0 0 0.16 72.5159 695.1656 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ۼ̻̼˼̻̻˻̻˻̺˻˻˻˻˼˺˻˻˺˻ʪ˺fx̼xܽ EI Q q 284.64 0 0 0.16 72.5159 695.0056 cm BI /W 593 /H 1 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284.64 0 0 0.16 72.5159 693.4056 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˺˻˼˻̺˼˫̺˻̻˻ܶ˻˺˻G˻v˻ EI Q q 284.64 0 0 0.16 72.5159 693.2457 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˹̺˼̼˻˼˻˻̻̻ܶ˻˻h˻v EI Q q 284.64 0 0 0.16 72.5159 693.0856 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܩ̺̼ܻ˻̼̼̻̻̻ܶ˻˻̻˫˻f EI Q q 284.64 0 0 0.16 72.5159 692.9257 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̺ܺf˼̻˼̻˼˪̼ܧz˼˻˻˻g̼ EI Q q 284.64 0 0 0.16 72.5159 692.7656 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ݬݻf̧̻̻̻̻̻˻˻̼̼ݸz˻̻˻˫˻W̻ EI Q q 284.64 0 0 0.16 72.5159 692.6057 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܼwܻ̻̺˼˺˫̧̻y̻˪y̻˻ܹ˻˻˻˻˻hy˼ EI Q q 284.64 0 0 0.16 72.5159 692.4456 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܼ̬̻˪̼̻ʪ˻̨i˫̼˺y˻̻ʫ̻˻˻hy˼ EI Q q 284.64 0 0 0.16 72.5159 692.2856 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻ݺܻ̼̻˪̻˼˻˻̨ܻi˪˻˺̻y˻˼˺˻˻˫g˻hy˻ EI Q q 284.64 0 0 0.16 72.5159 692.1256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻̻̻̪˻̻˻̨̻̻i˪̻̻˻˼˻˺̻˻˺yU˻hx EI Q q 284.64 0 0 0.16 72.5159 691.9656 cm BI 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689.0856 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܚ˻˼˻̻̻ʚ̼˻˻˻̻̻˼̻˹˻˻̻˺˻˼̻ EI Q q 284.64 0 0 0.16 72.5159 688.9257 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܛͻ˼̻˼̻˫˼˻̼˻˻˻˻̼˹˻˼˻̻˻˪̻˻˻̻ EI Q q 284.64 0 0 0.16 72.5159 688.7656 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ݻ̼˻̼ۼ˼ܻ˻˻˼̼˺̼̻˻˻̻̼̩̻˻˼˻˪˻̻ʫ˻ EI Q q 284.64 0 0 0.16 72.5159 688.6057 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̼̻˼̻̻˼˻˻˼˻̻̻̼̼̻̻˻̼˻˻˻˺˺ EI Q q 284.64 0 0 0.16 72.5159 688.4456 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˼˻˻̼̻˻̻˻˼˼˻˪̻̼˻̼̻˻ʫʫ˺ EI Q q 284.64 0 0 0.16 72.5159 688.2856 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻̼̼˻̻˻̻˻˻˼̻˻˼̼̼˻̻˼˻̺z˻ EI Q q 284.64 0 0 0.16 72.5159 688.1257 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻̻̼˼̺ʫ˻˻̻˻̻̼̼ܻ˼̻˻˻˻z̺ EI Q q 284.64 0 0 0.16 72.5159 687.9656 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻̻̻̻̻ʊ˻˻̼̼˻˻˻ʫ˻̻˻˼˻˪˻˻˼̻z EI Q q 284.64 0 0 0.16 72.5159 687.8056 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˼̼̻̻˼Y˻̻̻˻ʪ̻̼̼˼˼˼˪̻˻̻˺x EI Q q 284.64 0 0 0.16 72.5159 687.6456 cm BI /W 593 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/DeviceGray ID ˼̼̼̪˻˻̼Fh˻̼˻˫˻˪̻̻˼̻˻̻Q8˻˺̻ EI Q q 284.64 0 0 0.16 72.5159 686.0457 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܻ˼˪˻̺EW˼̻˼˻̼̻̻˼̻̻̼̻˼˻A'˻ EI Q q 284.64 0 0 0.16 72.5159 685.8856 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܻ̼˻ܼ̻̻EF˻˼̻˻˻˻˼̼̻̼˼˻˻A˻̻ EI Q q 284.64 0 0 0.16 72.5159 685.7256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܻ˻˼˻˼̻̻wVF̻̻˼̻̻˻̼̼̻˻̼˼˼˻P˻yg̻h̻ EI Q q 284.64 0 0 0.16 72.5159 685.5656 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻˺˼̻˼̻̻gf˧V̻̻˺˻̻˻˻˻̻˻qʪyxV˻f EI Q q 284.64 0 0 0.16 72.5159 685.4056 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻˻˼̫˼˺h˩x˻˻˺˻˻˻˻̻̻˻˻˻J̻yeyf˼f̻ EI Q q 284.64 0 0 0.16 72.5159 685.2457 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̼˫˼̫˻̻˨x˹̻˼˻˻̻˻˼˻˺˻̼̼̻˻̻˻˼˻ydJv˻˺V̻ EI Q q 284.64 0 0 0.16 72.5159 685.0856 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̼̼˼˫̻˼ܻ˺̻̻˫˫˼˻˻˼̼̻˻˼̻˻˻˻9˼F̻̼ EI Q q 284.64 0 0 0.16 72.5159 684.9256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̼˼˼˻̺̺˻̻˫˻˻˻˻̻̻˻˻˻˻JF˻˼ EI Q q 284.64 0 0 0.16 72.5159 684.7656 cm BI /W 593 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0.16 72.5159 674.3657 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̺˼̦z˩̼˻̻˻a K˻̼˕DgHh˼ EI Q q 284.64 0 0 0.16 72.5159 674.2056 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̩̻̼˦̼̺˻̼̻@K̻̼˦T˪xgX˪g˼ EI Q q 284.64 0 0 0.16 72.5159 674.0457 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˩̻̼˷̼˻̻˻̻ K˫˷WVwhW EI Q q 284.64 0 0 0.16 72.5159 673.8856 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˪̻˼˹̼˺̻˻̻:K˪̻i˻˻YTzyW EI Q q 284.64 0 0 0.16 72.5159 673.7256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻̻ʫ̻̻˻˻˻JK˫˻̼˺̫s9tiV EI Q q 284.64 0 0 0.16 72.5159 673.5656 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̺̻˻˼̻˻˻˻˪˻˙JK˫˻˻˻˻r8yV EI Q q 284.64 0 0 0.16 72.5159 673.4056 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̺̼˻̻˼̻˻˻˙YK˻̼̼˺b'wfʻ̼ EI Q q 284.64 0 0 0.16 72.5159 673.2457 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻˻̻˫˻˪̻̻j K˻̼˻˻b'xw EI Q q 284.64 0 0 0.16 72.5159 673.0856 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻ܼ˻˪˻˻jK˻̻̻̻̻ʫ˪s6 EI Q q 284.64 0 0 0.16 72.5159 672.9256 cm BI /W 593 /H 1 /BPC 4 /CS 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72.5159 671.3256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻˽̹˼˼˼˻˻˺Q&K̻˕i̺̻˻ʪ˻˪˻̺ EI Q q 284.64 0 0 0.16 72.5159 671.1656 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˺ʼډ˼ʈ˻̼˻K̻˕i̻˼˺̺̺ EI Q q 284.64 0 0 0.16 72.5159 671.0057 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˪ʼ˙˻˻˼˻˺K˻˻˖hܻ̻̼˻˻ܻ̻ EI Q q 284.64 0 0 0.16 72.5159 670.8456 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˺˺̘˩˪̻˻˻j[˻˻˨g̻̺˻̻̹ EI Q q 284.64 0 0 0.16 72.5159 670.6856 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˺̼̘˹ʪ˫˻˻̻̻̻˻` k˼W̻̼˻˪˺˻˻̺ EI Q q 284.64 0 0 0.16 72.5159 670.5256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˺˼̘˺˻̻̻˻̻`k̼˻˻˻W̻˻̻˼˺˻x˻ʫ EI Q q 284.64 0 0 0.16 72.5159 670.3657 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˼˺˼˚ܼ˺˻̻˻̻˻̻pQ˻˻˹Wܻ̼˻˻˻yʚ˻˼ EI Q q 284.64 0 0 0.16 72.5159 670.2056 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻̻̻˩ۻ˻˪˻˻˻̻˻˻˹Vܼ̼̻˻̻ʚ˻̼ EI Q q 284.64 0 0 0.16 72.5159 670.0457 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̼̻̫˼˺˻˻˼˪˼˻˩f̼̻˺̻̻ʙ EI Q q 284.64 0 0 0.16 72.5159 669.8857 cm BI /W 593 /H 1 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72.5159 625.5656 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܪܹx˹yy˫˻ʫ˼˺̻˻z̺̼˫̼˻˻C$˪˻ˠ EI Q q 284.64 0 0 0.16 72.5159 625.4056 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܻܹx˩yz˻˻ʫ˻wWz̩̼̻̻˻˻2#z˘˻̰ EI Q q 284.64 0 0 0.16 72.5159 625.2457 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻ܹ̼ʉ˘̼˪̻˻˼xB̻z̫̉˻d2#zvܼ̰ EI Q q 284.64 0 0 0.16 72.5159 625.0856 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻ܺ˚˪̻˺0hw˻˻c"$y̺U˺˰ EI Q q 284.64 0 0 0.16 72.5159 624.9257 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܻ˫ʫ˪̻˻˺w0(w̻˻R"4̹E˹̰ EI Q q 284.64 0 0 0.16 72.5159 624.7657 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̼ܼ̼˫˩˻w˹ w˻̻˩R#E˻̹Wzܻ̰ EI Q q 284.64 0 0 0.16 72.5159 624.6057 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˼۽̼˻̻ə˙˻e˹ ̈˻̻̻˼˻˩R4V˫̺ݻ{ EI Q q 284.64 0 0 0.16 72.5159 624.4456 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˬڬ̻˼ʙ˼˚˻Tz̚˼˻˻˼̻˻˻CEh˻˻uZ̰ EI Q q 284.64 0 0 0.16 72.5159 624.2856 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˫ڬ˻˻˩˻˫˼̻DJ̫̻̼˼CVy˻˻ܹEY EI Q q 284.64 0 0 0.16 72.5159 624.1257 cm BI /W 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۫ʫʬ˼˻̻̻˼̻˻j˻˻˼˻̻̻YYy̺˻ܺ EI Q q 284.64 0 0 0.16 72.5159 622.5256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ڬʫʬ˻˻˻̻z̻J˻̼̻˻˻iYeyz˪̻̻ EI Q q 284.64 0 0 0.16 72.5159 622.3657 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ۬˫ʼ̻˼˪z˻̻̻˻˺ytYTy˺˻ EI Q q 284.64 0 0 0.16 72.5159 622.2056 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ۽̻ڼ̻̻˫˫˻zf˻˻˻̼̼̼˻̻˻̻tiDh˺˻ EI Q q 284.64 0 0 0.16 72.5159 622.0457 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܽݼ˻˻˽̻˻˻˻˻˻˼˼̼̼̻˻˺DG˺̻˻ EI Q q 284.64 0 0 0.16 72.5159 621.8857 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˼ˬ̻̻˺˻˻ˬ˼˼˻̻˻C4̺˻̺˰ EI Q q 284.64 0 0 0.16 72.5159 621.7256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ݻܻˬܻ̻˻˼˻˻˻˫˼ܼ̼̼̻˻̻R#y˼̻˰ EI Q q 284.64 0 0 0.16 72.5159 621.5656 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻̻ˬ˻̼˻̻z˻ˆz˻6˻˫ۼ̼̼̼̻̻24i˻̻ EI Q q 284.64 0 0 0.16 72.5159 621.4056 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻ܼ˼˽˼̻̻˪̻z˻zpz˻˻̼̻˼̻14Y˼˻˼˽˫ EI Q q 284.64 0 0 0.16 72.5159 621.2457 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̺ʼ˼̻̼̻̻˻ugUz˻̼˺ܼ̻˼˻1$y˻ɋ EI Q q 284.64 0 0 0.16 72.5159 621.0856 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̺˻˻̻̻̻˻wcFYj˻̻˼̻˻̻˼˻1%˻̻̼Z EI Q q 284.64 0 0 0.16 72.5159 620.9257 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˼˻̼˻̫̻̼˻SV˻zj˻˼˻̼B6˻̼˻˻Y EI Q q 284.64 0 0 0.16 72.5159 620.7656 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˼˻̼˼˫̫̻̻TU˻Z̼˼̻˼̼ytg̻˻i EI Q q 284.64 0 0 0.16 72.5159 620.6057 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˼̻ݻ˼ʫ̫̻z˻ug˻Z˻̼̼̻̼̻˻h̻ʊ EI Q q 284.64 0 0 0.16 72.5159 620.4456 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ݻ˪ܻ̼̺̫˻z̼̻Z˻̼̼̻̼˻f˻˻̻˫ EI Q q 284.64 0 0 0.16 72.5159 620.2856 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ݺݻ˪ܻ̺̺̫̺̻yZ̻̻̻˻V˻̼ܻ EI Q q 284.64 0 0 0.16 72.5159 620.1257 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܺݪ˻̺ܺʻ˫˺̼y˺[˻̻̻̼̻˹˻V̻ EI Q q 284.64 0 0 0.16 72.5159 619.9656 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܺݺ˻̻̺˻˫̺˻k̻˻˼̻̹˻V̻̼ EI Q q 284.64 0 0 0.16 72.5159 619.8057 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܺܺ˻̺̼˻̺̻˪k̻̼̻˹˻g˻ EI Q q 284.64 0 0 0.16 72.5159 619.6456 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܪ̺̻̺˺̻̺˺˺pk˻̼̼̺˺˻ EI Q q 284.64 0 0 0.16 72.5159 619.4857 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܼ̺ܺ˼̻̻˪˻̺̼˺˺pk̻̻̼̺˻ EI Q q 284.64 0 0 0.16 72.5159 619.3256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̼̺ܺ˼̻˼˺˩xz̼̻̼̺̻̻ EI Q q 284.64 0 0 0.16 72.5159 619.1656 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˼ݺ̪˻̻˼˼˺˹˺z˻˨{˻̼˫˻̺˻x̼̰ EI Q q 284.64 0 0 0.16 72.5159 619.0057 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻˺ݪ˻˻˼˼̺˻̻uz̺`˻̼˫˼˺̻̻˻˺h˻˼̼ EI Q q 284.64 0 0 0.16 72.5159 618.8456 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻˻ͻ˼˻˼̼˪˻˺u˻̼̻̻̻˻˼˻w˼˼̼̼̰ EI Q q 284.64 0 0 0.16 72.5159 618.6857 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܻͻ˻˻˼˼˪˼̻v ˻ʼ˻˼˫̻˻˺wx̼̼˰ EI Q q 284.64 0 0 0.16 72.5159 618.5256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ݻܻ˼̻̻˼˼̼̼˺˻zwr̼ʬ˻̻̺˻̼˻x̼ܼ˰ EI Q q 284.64 0 0 0.16 72.5159 618.3657 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܻ˼̼˻̻̻̼̺̻˻˻˻ˬ˼̻˺̻˼̼x˻˰ EI Q q 284.64 0 0 0.16 72.5159 618.2056 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܻ̼ܼ̻˼̻̻̺˻˻˻̻˫̼˼̺˻̻˻x˼˰ EI Q q 284.64 0 0 0.16 72.5159 618.0457 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܻ˻̻˻˻̺̻˻ܻ˻̼˼̺̻˻̼̼˰ EI Q q 284.64 0 0 0.16 72.5159 617.8857 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܻʻ̻˻̻˻˺˻˻̻̻ͼ̻˻̺ʼ̻̻˻v̻˰ EI Q q 284.64 0 0 0.16 72.5159 617.7256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܻ̺̻̼̻̺˻˻˻˼̻̼̻˻˼ʼ˼˺T̻˼˰ EI Q q 284.64 0 0 0.16 72.5159 617.5657 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܻ̺̼̼̻̩˺˺̻̻̼̻˻̺̻y˥Ci̼˰ EI Q q 284.64 0 0 0.16 72.5159 617.4056 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ۻ̺̼̻̼˻̩˻˻̻˻˻̺̼̻vy3i̻˰ EI Q q 284.64 0 0 0.16 72.5159 617.2457 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ۻͻ̺˻̼̼˻˙̻˻̻ܼ˺̻̻̻u#Y̻ˠ EI Q q 284.64 0 0 0.16 72.5159 617.0856 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻ܻ̻˻̼˻ˈ˻˻ܼ˩̻ܻ˻uyz3i̼ʠ EI Q q 284.64 0 0 0.16 72.5159 616.9257 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻ܻܻ˼̼x˻˻ܼ̼̻ʘ˻˼˺wuztiE̼ʐ EI Q q 284.64 0 0 0.16 72.5159 616.7657 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܻ˻ܻ˼̻ˉ˻˺̼˻ʘ˼˼˻vvSXg˼̺ EI Q q 284.64 0 0 0.16 72.5159 616.6057 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̼̻۫˙˻˺˻̼˻˼˼̻vw2Gy̺ EI Q q 284.64 0 0 0.16 72.5159 616.4457 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ͺ˫˼̺˪˻˺˻˻˻˻W"7̺ EI Q q 284.64 0 0 0.16 72.5159 616.2856 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻˫ܻ˻̻̺̻˻˻̼̺˼˻˼̻˻y6!7̼ʠ EI Q q 284.64 0 0 0.16 72.5159 616.1257 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܻ̼ˬ˛̻˻̺˫̼̻˼̼̻˼˫˼˻˻7"G˻ˠ EI Q q 284.64 0 0 0.16 72.5159 615.9656 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܻ˼ɋ̺̼̹˻̻˺̻̻˼̻̻̼˼˫̻˼̼˻iH"H˻̼̼̰ EI Q q 284.64 0 0 0.16 72.5159 615.8057 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܻȋ˪ܹ̻˻˪̻˻̻̻˼˻˪˼˻̻Xi4i˻̰ EI Q q 284.64 0 0 0.16 72.5159 615.6457 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻ɬ˙̻̺̺̻˪̼̻y˻˻̻˻̼̼˻̼GV˻̼̰ EI Q q 284.64 0 0 0.16 72.5159 615.4857 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̼ˬ˼̺˻˻̺˼̼˪˻˻̻̻˼y˼̼˻̻Gx˪̰ EI Q q 284.64 0 0 0.16 72.5159 615.3256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻ʬ̺˻˼̘˪˻̻̻˼˪̻G̼̻yG˼̰ EI Q q 284.64 0 0 0.16 72.5159 615.1656 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̼Ɍ̻ܻ˺̻̘̺˻uw̻ܼ̼̽˻˪˻'̻iW̰ EI Q q 284.64 0 0 0.16 72.5159 615.0057 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ɜ˘˪˪̙̻̻˻ef˻̻̻̼̼̻̪˻&˼̼̻Xg˻̼̠ EI Q q 284.64 0 0 0.16 72.5159 614.8456 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܹʘ˚˫̼̼̩̻˻ee˺̼˻ܼ̻̺˻%˼˻˼˻Xx̐ EI Q q 284.64 0 0 0.16 72.5159 614.6857 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܹܽ˘̺y˼̼˻̩̼̼̻eUz˻̻˻˻ܼ̻˻7̻˻˺X̻̼p EI Q q 284.64 0 0 0.16 72.5159 614.5256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܹۼ˘̻̺y˻˼̻˻̼˻wUi̻˻̼ݻ̻i̼̻x̻̀ EI Q q 284.64 0 0 0.16 72.5159 614.3657 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܼܹ˨̻̺y̼˼ۼ˻˻ei˺˻˻̼ۼ̼̻˺˻̀ EI Q q 284.64 0 0 0.16 72.5159 614.2056 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻ݹ˪̻̺y˼̼˻˼˺H˻̼˼̻˻˻˻zw̼̼̼̐ EI Q q 284.64 0 0 0.16 72.5159 614.0457 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̫̻̻̺̻̼̻ܽܺHܼ˻˼˻˻uyg˼̠ EI Q q 284.64 0 0 0.16 72.5159 613.8856 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̼˻ܻ˼˼ܻ˪̼̻̼˻6˻˼̼̼˻˻txy̼̼̠ EI Q q 284.64 0 0 0.16 72.5159 613.7256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ۽̼ݻ̼̻˫̻ʪ̻̺5zx˻˼̼̼˼˻̻tzgywJ̼˰ EI Q q 284.64 0 0 0.16 72.5159 613.5656 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̼̼˼̻˻˻˺̻۪5W˪̻˼˼̼̻̻̻̻W˻̼˼˰ EI Q q 284.64 0 0 0.16 72.5159 613.4056 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̼̼ͼܻ˼̼˻̻˻˻˪FG˻̼̽˼˼˻˻̻̻˨˻̼̻˰ EI Q q 284.64 0 0 0.16 72.5159 613.2457 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˼̼ܻʫ˪̼̻̻˪WwG̻˻˼˼̻̪̻˻˻˪̻̼˰ EI Q q 284.64 0 0 0.16 72.5159 613.0856 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻˼̺˫ʛ̻˪˻̺̩x˪eXwW˼̻̼̻˫˼˻˺̻˼˼˰ EI Q q 284.64 0 0 0.16 72.5159 612.9257 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܻ˻ͺ̻˪˻̺h̻wXiix˻˼̼˽̻˚˫˻̻˼j̼˰ EI Q q 284.64 0 0 0.16 72.5159 612.7657 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܻ˻ܻ̻ʫ{̻ʚ̼̻̻˙y˻wYh˻˼̼˪˫ʚ˻̼˻̻˻w:̼̼˰ EI Q q 284.64 0 0 0.16 72.5159 612.6057 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ۻ˻̺̻̼̺˪˻xhy̼˻˼̼˼̻˫˻˻˻˻̻˰ EI Q q 284.64 0 0 0.16 72.5159 612.4456 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ۻ̻ܺ˫̻˼̻̻˪xx˻˽̼̻̻˻̼˻˻˻p˻˻̼˰ EI Q q 284.64 0 0 0.16 72.5159 612.2856 cm BI 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72.5159 596.4457 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻̫̼̻˻˻̻˻˼̺˼˻˺x˺̼ܻ˼˻˼̻˪˻˻̻˻TF˻˼˻ EI Q q 284.64 0 0 0.16 72.5159 596.2856 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻̫˼˺̻˼̹˺̻˻̼̻˼ۻ˪˻˻˻˻vyC4˻ EI Q q 284.64 0 0 0.16 72.5159 596.1257 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻ܫ˻˻̹˹˺̻ˬ˻̻˻˪˻˪˻eyB$z EI Q q 284.64 0 0 0.16 72.5159 595.9656 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻̻˻̺̻̻̼̹˻̼ʋ˻̻˻̻˼˚˻g2#z˰ EI Q q 284.64 0 0 0.16 72.5159 595.8057 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻ܻ̼˻ʻ˺̻̻̹̺˪z̻Ɋ˩˻˻̻̻˻˪˻2$z˻̻̻˰ EI Q q 284.64 0 0 0.16 72.5159 595.6456 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˫̼˻˻˺̻˼̺˺̻˻˻y̼͸z˩̻̼ܻ˺̪h24z˻ EI Q q 284.64 0 0 0.16 72.5159 595.4857 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˬܼ˻̻̻˺˺̻y̻ܻܨz˩z̻˼̻̻̪˹gC4˻˻˫ EI Q q 284.64 0 0 0.16 72.5159 595.3256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̼̼˻̺˻̻̻̻˻˻y̻̼ܨ˹j̻̼˻̻̻˻˻˻˻h˻DE˻̻̰ EI Q q 284.64 0 0 0.16 72.5159 595.1656 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˼˻̺˼˻˻˻vyܩ˨˻˼˻ܻ˪̪ifV˻ EI Q q 284.64 0 0 0.16 72.5159 595.0057 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻˫̺̻˻˻̻vܩ̨˻˻˻˼̺˺xhg̻ EI Q q 284.64 0 0 0.16 72.5159 594.8456 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܼ˻˪˼ܺ˼̻̻˻vy˼̹̚˻˻˻̻̻˺hy̻˻ EI Q q 284.64 0 0 0.16 72.5159 594.6856 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܼ˻˼˚˻˺˻˩v˼ܫ̻˻̻̻̺̻˻h˻̻ EI Q q 284.64 0 0 0.16 72.5159 594.5256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻̺˪˻˻̻ʙyv̻̼̺۫˻˺˻˫˻h˻˻ EI Q q 284.64 0 0 0.16 72.5159 594.3657 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻̻˪˼̻˻˼˻yw̼̺۫˻̻˻˫˻̻Vxx˻s EI Q q 284.64 0 0 0.16 72.5159 594.2056 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̺̻˪˻˫˺˺̻xy̼ʫ̼̺˻ܼ̼˻˻˻̻Vxx˻˻˪r{ EI Q q 284.64 0 0 0.16 72.5159 594.0457 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̺̻̻̻˫zʺ˺̺X̼̺̺̻˼˻˼Wx˺̻˪r˻ EI Q q 284.64 0 0 0.16 72.5159 593.8857 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˼ܻ˺̪˻̻˫j˻X̺̼̺̺̻˻˻̻̻˺˺̻g˻˺̻ EI Q q 284.64 0 0 0.16 72.5159 593.7256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻ܻ̻ܽ˫˻̻̻˻i̻i˺̻̻̻˻˼˻̻x EI Q q 284.64 0 0 0.16 72.5159 593.5657 cm BI /W 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cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID EI Q q 284.64 0 0 0.16 72.5159 588.7657 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID EI Q q 284.64 0 0 0.16 72.5159 588.6057 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID EI Q q 284.64 0 0 0.16 72.5159 588.4456 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID EI Q q 284.64 0 0 0.16 72.5159 588.2856 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID EI Q q 284.64 0 0 0.16 72.5159 588.1257 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID EI Q q 284.64 0 0 0.16 72.5159 587.9656 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID EI Q q 284.64 0 0 0.16 72.5159 587.8057 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID EI Q q 284.64 0 0 0.16 72.5159 587.6457 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID EI Q q 284.64 0 0 0.16 72.5159 587.4857 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID EI Q q 284.64 0 0 0.16 72.5159 587.3257 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID EI Q q 284.64 0 0 0.16 72.5159 587.1656 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID EI Q q 284.64 0 0 0.16 72.5159 587.0057 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID EI Q q 284.64 0 0 0.16 72.5159 586.8456 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID EI Q q 284.64 0 0 0.16 72.5159 586.6857 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID EI Q q 284.64 0 0 0.16 72.5159 586.5256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻ EI Q q 284.64 0 0 0.16 72.5159 586.3657 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̺ʙ EI Q q 284.64 0 0 0.16 72.5159 586.2056 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻ EI Q q 284.64 0 0 0.16 72.5159 586.0457 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˼ʘ̼˻̻̼ EI Q q 284.64 0 0 0.16 72.5159 585.8857 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܻ̻̻̼̼̼̼˼ EI Q q 284.64 0 0 0.16 72.5159 585.7256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܻ˪̼̼̻ EI Q q 284.64 0 0 0.16 72.5159 585.5657 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻˻̼̻ EI Q q 284.64 0 0 0.16 72.5159 585.4056 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻ܼ̻ EI Q q 284.64 0 0 0.16 72.5159 585.2457 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܼ̺ۼ̼̼˺ EI Q q 284.64 0 0 0.16 72.5159 585.0856 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܺ˼̻˼̼˻ EI Q q 284.64 0 0 0.16 72.5159 584.9257 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̺̺̻ڭ̻˻̼̼˼̻˺ EI Q q 284.64 0 0 0.16 72.5159 584.7657 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˺ͺ̻̪̼̼˻˼̼̻̻̻ EI Q q 284.64 0 0 0.16 72.5159 584.6057 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻̺̻˩̼̼̼̻˼̼̼˼˻˻˺˻ EI Q q 284.64 0 0 0.16 72.5159 584.4457 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻̻̻˙˻̼̻̻̼˻̼̼˺˻˺ EI Q q 284.64 0 0 0.16 72.5159 584.2856 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻̺ܼ̻̻˙˻ˬ̻˻̻˼˼˺˻̻˼ EI Q q 284.64 0 0 0.16 72.5159 584.1257 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻̺˻˻ۻ˻˚˼̻˻̼̻̼˻˼˺ EI Q q 284.64 0 0 0.16 72.5159 583.9656 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻˻̼˻|ڻ̺̻˻˻̼̼˼˺ܻ˪˻ EI Q q 284.64 0 0 0.16 72.5159 583.8057 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻̻̻˻˫̻̼˼̻̼˻̻̻̻ EI Q q 284.64 0 0 0.16 72.5159 583.6456 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻̻̺̻˻̻˼̻˼ܻ˺̺ EI Q q 284.64 0 0 0.16 72.5159 583.4857 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻̪̺wx˻˻˻˻˼̻˻˻˻ܼ̻˺˻ EI Q q 284.64 0 0 0.16 72.5159 583.3256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻ܺg̻˺˻̺̻˻ܻܻ˻ EI Q q 284.64 0 0 0.16 72.5159 583.1656 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻ʩgݽ̼ܽ˺̻˪̻̻̻̻˻ܻ̻˻ EI Q q 284.64 0 0 0.16 72.5159 583.0057 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˫̻̻۪w̼˺̼˺˻˻˻ܻ̻ EI Q q 284.64 0 0 0.16 72.5159 582.8456 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID R"Jܼ̻ۺ˻˺˻˻̻˻˻˼̺̻ EI Q q 284.64 0 0 0.16 72.5159 582.6857 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID !!̻˺ܺx̻vz˻˻˻˼˻̻̻ EI Q q 284.64 0 0 0.16 72.5159 582.5256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID 1*ۺܪܼ˻˻zvi˺˻˻̻̻̻ EI Q q 284.64 0 0 0.16 72.5159 582.3657 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ܻ̪˪˺zܷG۫˻˺yei̻˻ EI Q q 284.64 0 0 0.16 72.5159 582.2056 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ̻˪˪̻vy`lܬ"$˻vyivy̻̻˻̼ EI Q q 284.64 0 0 0.16 72.5159 582.0457 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ~ܻ۪̻ʪeh˪vUhuiwy˩˻˨̼ EI Q q 284.64 0 0 0.16 72.5159 581.8857 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID AMܻ̩̼۪yUF+˺ffhdyw˻˘̼ EI Q q 284.64 0 0 0.16 72.5159 581.7256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID !,˪ܪS5x˻Uwxexwy̻BJ˻̼ EI Q q 284.64 0 0 0.16 72.5159 581.5657 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˩ܻC4gݐ˻Exeyw̻̻ EI Q q 284.64 0 0 0.16 72.5159 581.4056 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID #c˪˫uUS#Ez` \L̻˻Exgww̻{˻ EI Q q 284.64 0 0 0.16 72.5159 581.2457 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID ˻̺˻˂Ks#i P ˩̻p<`\ޡ-P EI Q q 284.64 0 0 0.16 72.5159 579.3256 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID !>̻ܻ̻̼q:#Y@!0 ˩w܀Lp\1ݡ]혙@ EI Q q 284.64 0 0 0.16 72.5159 579.1656 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID !N˻˪˻ܻ̼̻a:#H0!P ˼˩wx̻̼pL`\PL͠1 $D EI Q q 284.64 0 0 0.16 72.5159 579.0057 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID N̼̻˪˻˚QL3Gx0!,` ˻˙w˼p<`[@|11 EI Q q 284.64 0 0 0.16 72.5159 578.8456 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID !N˻̻˼iA:3Gvg @!-p ̻̻w̻܀;̻`[0,A! EI Q q 284.64 0 0 0.16 72.5159 578.6857 cm BI /W 593 /H 1 /BPC 4 /CS /DeviceGray ID N˻̻˻ˬ˼GCJCFeW̼ܰ @!,p̻˩˩˻݀<ܻ`[ > endobj 18 0 obj<>/ProcSet[/PDF/Text/ImageB]/ExtGState<>>> endobj 19 0 obj<>stream 0 0 0 1 k BX /GS2 gs EX 1 i 288.04 -22.076 35.921 83.815 re f BT /F14 1 Tf 9.978 0 0 9.978 72.516 353.438 Tm 0 Tc [(model)-502(\(1994\))-502(changes)-502(in)-502(pCREB)-502(were)-502(transient)]TJ 0 -1.2 TD [(with)-319.9(increases)-319.9(peaking)-319.9(at)-319.9(10)-319.9(min)-319.9(after)-319.9(the)-319.9(session)]TJ T* [(and)-486.3(returning)-486.3(near)-486.3(the)-486.3(control)-486.3(range)-486.3(at)-486.3(60)-486.3(min)]TJ T* [(after)-416.7(the)-416.7(session.)-416.7(This)-416.7(pattern)-416.7(is)-416.7(similar)-416.7(to)-416.7(previ-)]TJ T* [(ously)-312.8(reported)-312.8(temporal)-312.8(patterns)-312.8(of)-312.8(pCREB)-312.8(activa-)]TJ T* [(tion)-314.2(\()-100(Bito)-314.2(et)-314.2(al.)-314.2(1996;)-314.2(Impey)-314.2(et)-314.2(al.)-314.2(1996;)-314.2(Moore)-314.2(et)]TJ T* [(al.)-517(1996;)-517(Matthies)-517(et)-517(al.)-517(1997;)-517(Deisseroth)-517(et)-517(al.)]TJ T* [(1998\))-220.7(and)-220.7(is)-220.7(consistent)-220.7(with)-220.7(the)-220.7(rapid)-220.7(and)-220.7(transient)]TJ T* [(time)-303.4(course)-303.4(required)-303.4(for)-303.4(the)-303.4(catalytic)-303.4(C)-303.4(subunit)-303.4(of)]TJ T* [(protein)-274.4(kinase)-274.4(A)-274.4(t)0(o)-274.4(translocate)-274.4(to)-274.4(the)-274.4(nucleus)-274.4(after)]TJ T* [(adenylate)-632.1(cyclase)-59.9(/)-59.9(cAMP)-632.1(activation)-632.1(\()-100(Nigg)-632.1(et)-632.1(al.)]TJ T* (1985\).)Tj 1.8 -1.2 TD [(Given)-442.6(the)-442.6(overall)-442.6(increase)-442.6(in)-442.6(pCREB)-442.6(protein)]TJ -1.8 -1.2 TD [(\()-100(Western)-342.6(blots\))-342.6(in)-342.6(the)-342.6(bulb)-342.6(associated)-342.6(with)-342.6(learn-)]TJ T* [(ing)-450.3(\(Odor)-264.8(+)-264.7(Stroking\),)-450.3(one)-450.3(might)-450.3(have)-450.3(predicted)]TJ T* [(substantial)-306.8(increases)-306.8(in)-306.8(pCREB)-306.8(observed)-306.8(by)-306.8(immu-)]TJ T* [(nocytochemistry.)-452(While)-452(we)-452(did)-452(observe)-452(regional)]TJ T* [(and)-379.8(cell)-379.8(specific)-379.8(increases,)-379.8(the)-379.8(overall)-379.8(number)-379.8(of)]TJ T* [(pCREB)-257.9(cells)-257.9(localized)-257.9(in)-257.9(all)-257.9(populations)-257.9(in)-257.9(the)-257.9(bulb)]TJ T* [(did)-323(not)-323(appear)-323(to)-323(be)-323(dramatically)-323(increased)-323(in)-323(the)]TJ T* [(learning)-252.8(\(Odor)-264.8(+)-264.7(Stroking\))-252.8(situation.)-252.8(A)-252.8(possible)-252.8(ex-)]TJ T* [(planation)-524.7(for)-524.7(this)-524.7(apparent)-524.7(discrepancy)-524.7(may)-524.7(be)]TJ T* [(that)-413.3(large)-413.3(mitral)-413.3(cells)-413.3(produce)-413.3(a)-413.3(large)-413.3(amount)-413.3(of)]TJ 25.2 26.4 TD [(pCREB,)-316.7(which)-316.7(may)-316.7(not)-316.7(be)-316.7(reflected)-316.7(by)-316.7(cellular)-316.7(lo-)]TJ 0 -1.2 TD [(calization)-533.2(with)-533.2(immunocytochemistry)-533.2(but)-533.2(is)-533.2(de-)]TJ T* [(tectable)-332.9(by)-332.9(Western)-332.9(blot)-332.9(analysis.)]TJ 1.8 -1.2 TD [(In)-476.4(the)-476.4(present)-476.4(study,)-476.4(the)-476.4(localization)-476.4(of)-476.4(the)]TJ -1.8 -1.2 TD [(pairing-associated)-364.7(pCREB)-364.7(changes)-364.8(in)-364.7(the)-364.7(dorsolat-)]TJ T* [(eral)-536.1(olfactory)-536.1(bulb)-536(overlaps)-536.1(with)-536.1(the)-536.1(midlateral)]TJ T* [(portion)-399.7(of)-399.7(the)-399.7(bulb)-399.7(shown)-399.7(to)-399.7(be)-399.7(associated)-399.7(with)]TJ T* [(increased)-311.3(2-deoxyglucose)-311.3(activity)-311.3(in)-311.3(rats)-311.3(that)-311.3(have)]TJ T* [(been)-484.3(conditioned)-484.3(to)-484.3(the)-484.3(same)-484.3(peppermint)-484.4(odor)]TJ T* [(\(Coopersmith)-457.4(and)-457.4(Leon)-457.4(1986;)-457.4(Sullivan)-457.4(and)-457.4(Leon)]TJ T* [(1986a,)-252.5(1987;)-252.5(Sullivan)-252.5(et)-252.5(al.)-252.5(1988;)-252.5(Woo)-252.5(et)-252.5(al.)-252.5(1987)-100(\).)]TJ T* [(The)-435.8(localization)-435.8(of)-435.8(pCREB)-435.8(in)-435.8(the)-435.8(dorsolateral)-435.8(re-)]TJ T* [(gion)-240.9(correlates)-240.9(very)-240.9(well)-240.9(to)-240.9(c-)]TJ /F17 1 Tf 12.4779 0 TD (fos)Tj /F14 1 Tf 1.4818 0 TD [(mRNA)-240.9(expression)]TJ -13.9598 -1.2 TD [(in)-516.7(response)-516.7(to)-516.7(peppermint)-516.8(odor)-516.7(\(Guthrie)-516.7(et)-516.7(al.)]TJ T* [(1993\),)-342.6(which)-342.6(was)-342.6(shown)-342.6(to)-342.6(activate)-342.6(periglomeru-)]TJ T* [(lar,)-261.6(mitral,)-261.6(and)-261.6(granule)-261.6(cells)-261.6(in)-261.6(adult)-261.6(rats)-261.6(and)-261.6(to)-261.6(the)]TJ T* [(general)-296(region)-296(\(midlateral\))-296(of)-296(c-)]TJ /F17 1 Tf 13.5454 0 TD (fos)Tj /F14 1 Tf 1.537 0 TD [(activated)-296(by)-296(re-)]TJ -15.0824 -1.2 TD [(trieval)-347.4(of)-347.4(a)-347.4(conditioned)-347.4(peppermint)-347.4(odor)-347.4(in)-347.4(older)]TJ T* [(pups)-362.5(\()-100(Johnson)-362.5(et)-362.5(al.)-362.5(1995\).)-362.5(However,)-362.5(in)-362.5(retrieval)]TJ T* [(studies,)-474.1(increases)-474.1(in)]TJ /F17 1 Tf 9.368 0 TD (fos)Tj /F14 1 Tf 1.2409 0 TD [(-reactive)-474.1(cells)-474.1(have)-474.1(been)]TJ -10.6089 -1.2 TD [(associated)-419.6(selectively)-419.6(with)-419.6(the)-419.6(periglomerular)-419.6(re-)]TJ T* [(gion)-332.4(in)-332.4(response)-332.4(to)-332.4(peppermint)-332.4(odors)-332.4(\(Guthrie)-332.4(et)]TJ T* [(al.)-357.7(1993;)-357.7(Johnson)-357.6(et)-357.7(al.)-357.7(1995;)-357.7(Schwab)-357.6(1996\).)-357.7(Cell)]TJ ET 0 g BX /GS1 gs EX q 256.32 0 0 0.9 283.286 719.3843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ?????????? EI Q q 256.32 0 0 0.9 283.286 718.4843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ???????x???????????8 ?!p1?Àp0 a p<? EI Q q 256.32 0 0 0.9 283.286 713.9843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ! ?`~>???!>>?q? EI Q q 256.32 0 0 0.9 283.286 713.0844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ?? EI Q q 256.32 0 0 0.9 283.286 712.1843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ? EI Q q 256.32 0 0 0.9 283.286 711.2843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ??s???y~ < EI Q q 256.32 0 0 0.9 283.286 710.3843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ~>?C<<>>ij<>? EI Q q 256.32 0 0 0.9 283.286 709.4843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID @A``@x<??x<p0p|qp`8|????x~p|8x>CqÇ 0??Ç8~08|~ကCqq?Ç? 0??Ç8~0|(x~Cqq? EI Q q 256.32 0 0 0.9 283.286 708.5844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ? 0??Çx~ 08|~Cqq?? 0??Çx~ Ç08|~Gqq?? 0??Ç8 p8|~?qq?Ç  ?Ïಹ0>?08p8?฿00Ĵ88<pqpp?``pp~8~?p<pqxp? EI Q q 256.32 0 0 0.9 283.286 706.7843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ?p88?< pp|q?p<8?< ?qq8<?? EI Q q 256.32 0 0 0.9 283.286 705.8843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID EI Q q 256.32 0 0 0.9 283.286 704.9843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID EI Q q 256.32 0 0 0.9 283.286 704.0843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID EI Q q 256.32 0 0 0.9 283.286 703.1843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID EI Q q 256.32 0 0 0.9 283.286 702.2843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID EI Q q 256.32 0 0 0.9 283.286 701.3843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID EI Q q 256.32 0 0 0.9 283.286 700.4843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID EI Q q 256.32 0 0 0.9 283.286 699.5844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID EI Q q 256.32 0 0 0.9 283.286 698.6843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ?? EI Q q 256.32 0 0 0.9 283.286 697.7843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID x?x EI Q q 256.32 0 0 0.9 283.286 696.8843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ?? ?  EI Q q 256.32 0 0 0.9 283.286 695.9843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ?? EI Q q 256.32 0 0 0.9 283.286 695.0844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID g??c?cO EI Q q 256.32 0 0 0.9 283.286 694.1843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ?`x?q8a EI Q q 256.32 0 0 0.9 283.286 693.2843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID !0?0 p  EI Q q 256.32 0 0 0.9 283.286 692.3843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID x0|ǁqǁp EI Q q 256.32 0 0 0.9 283.286 691.4843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID  EI Q q 256.32 0 0 0.9 283.286 690.5844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID Ώ/ EI Q q 256.32 0 0 0.9 283.286 689.6843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID  EI Q q 256.32 0 0 0.9 283.286 688.7843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID gÇ EI Q q 256.32 0 0 0.9 283.286 687.8843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID |3|#!x?c~a0p 0 EI Q q 256.32 0 0 0.9 283.286 686.9843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID q1q113 EI Q q 256.32 0 0 0.9 283.286 686.0844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID s1s0?30?8 EI Q q 256.32 0 0 0.9 283.286 685.1843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID < EI Q q 256.32 0 0 0.9 283.286 684.2843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID  EI Q q 256.32 0 0 0.9 283.286 683.3843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ?? EI Q q 256.32 0 0 0.9 283.286 682.4843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID 0?8ox??? EI Q q 256.32 0 0 0.9 283.286 681.5844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID @ ?Gx EI Q q 256.32 0 0 0.9 283.286 680.6843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ????>??x EI Q q 256.32 0 0 0.9 283.286 679.7843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID g?pǀ ?? EI Q q 256.32 0 0 0.9 283.286 678.8843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID  EI Q q 256.32 0 0 0.9 283.286 677.9843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID p x EI Q q 256.32 0 0 0.9 283.286 677.0844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ??q? EI Q q 256.32 0 0 0.9 283.286 676.1843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID 8q|0~`x? ?9? EI Q q 256.32 0 0 0.9 283.286 675.2843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID  ?xǀ?ǀq0?ǀ11? EI Q q 256.32 0 0 0.9 283.286 674.3843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID 11>?11>?11?<11 ? EI Q q 256.32 0 0 0.9 283.286 673.4843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID  p1? p81?1?>? EI Q q 256.32 0 0 0.9 283.286 672.5844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ?? EI Q q 256.32 0 0 0.9 283.286 671.6843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID  EI Q q 256.32 0 0 0.9 283.286 670.7843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID  EI Q q 256.32 0 0 0.9 283.286 669.8843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID  EI Q q 256.32 0 0 0.9 283.286 668.9843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID  EI Q q 256.32 0 0 0.9 283.286 668.0844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ? EI Q q 256.32 0 0 0.9 283.286 667.1843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID  EI Q q 256.32 0 0 0.9 283.286 666.2843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID  ??? EI Q q 256.32 0 0 0.9 283.286 665.3843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ??>?? EI Q q 256.32 0 0 0.9 283.286 664.4843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID  EI Q q 256.32 0 0 0.9 283.286 663.5844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID  |xp| EI Q q 256.32 0 0 0.9 283.286 662.6843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID aa EI Q q 256.32 0 0 0.9 283.286 661.7843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID  EI Q q 256.32 0 0 0.9 283.286 660.8843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID  EI Q q 256.32 0 0 0.9 283.286 659.9843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID  EI Q q 256.32 0 0 0.9 283.286 659.0844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID 00 EI Q q 256.32 0 0 0.9 283.286 658.1843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID  EI Q q 256.32 0 0 0.9 283.286 657.2843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ???????? EI Q q 256.32 0 0 0.9 283.286 656.3843 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ???? EI Q q 256.32 0 0 0.9 283.286 655.4844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ????? EI Q q 256.32 0 0 0.9 283.286 654.5844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ???? 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EI Q q 256.32 0 0 0.9 283.286 434.9844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID  EI Q q 256.32 0 0 0.9 283.286 434.0844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID  EI Q q 256.32 0 0 0.9 283.286 433.1844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID  EI Q q 256.32 0 0 0.9 283.286 432.2844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ? EI Q q 256.32 0 0 0.9 283.286 431.3844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ??ϟ EI Q q 256.32 0 0 0.9 283.286 430.4844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID  EI Q q 256.32 0 0 0.9 283.286 429.5844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ? EI Q q 256.32 0 0 0.9 283.286 428.6844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ???> EI Q q 256.32 0 0 0.9 283.286 427.7844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ?<|xρ|| EI Q q 256.32 0 0 0.9 283.286 426.8844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ?̥ EI Q q 256.32 0 0 0.9 283.286 425.9844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID  ? EI Q q 256.32 0 0 0.9 283.286 425.0844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID a?a?0a?0? EI Q q 256.32 0 0 0.9 283.286 424.1844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ???? EI Q q 256.32 0 0 0.9 283.286 423.2844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ???? EI Q q 256.32 0 0 0.9 283.286 422.3844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ???0? EI Q q 256.32 0 0 0.9 283.286 421.4844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID 0?0?0??? EI Q q 256.32 0 0 0.9 283.286 420.5844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ????? EI Q q 256.32 0 0 0.9 283.286 419.6844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ? _??????  EI Q q 256.32 0 0 0.9 283.286 418.7844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ?????? EI Q q 256.32 0 0 0.9 283.286 417.8844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ???? EI Q q 256.32 0 0 0.9 283.286 416.9844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ????? EI Q q 256.32 0 0 0.9 283.286 416.0844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ????ß?? EI Q q 256.32 0 0 0.9 283.286 415.1844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID '<??>?? EI Q q 256.32 0 0 0.9 283.286 414.2844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID >?>??~?0~? EI Q q 256.32 0 0 0.9 283.286 413.3844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ~?>?x>? EI Q q 256.32 0 0 0.9 283.286 412.4844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ?|xρ||? EI Q q 256.32 0 0 0.9 283.286 411.5844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID ??"???>߁i?/? EI Q q 256.32 0 0 0.9 283.286 382.7844 cm BI /W 1068 /H 4 /BPC 1 /IM true ID <Ϗ$ xp#]d?<Ϗ<Ǐ@ p pg>pG EI Q q 256.32 0 0 0.66 283.286 382.1244 cm BI /W 1068 /H 3 /BPC 1 /IM true ID xσ>| EI Q BT /F18 1 Tf 8.98 0 0 8.98 72.516 458.955 Tm BX /GS2 gs EX [(Figure)-452.9(6:)]TJ /F19 1 Tf 5.0097 0 TD [(Graph)-452.9(showing)-452.9(the)-452.9(density)-452.9(of)-452.9(pCREB)]TJ -5.0097 -1.2222 TD [(immunoreactive)-366.8(cells)-366.8(\(%)-366.7(area)-366.8(reaching)-366.8(threshold\))]TJ T* [(in)-256.6(various)-256.6(regions)-256.6(of)-256.6(the)-256.6(olfactory)-256.6(bulb.)-256.6(Notice)-256.6(that)]TJ T* [(a)-291.3(significantly)-291.3(higher)-291.3(level)-291.3(of)-291.3(pCREB)-291.3(label)-291.3(was)-291.3(ob-)]TJ T* [(served)-381(in)-381(the)-381(dorsolateral)-381(quadrant)-381(mitral)-381(cells)-381(in)]TJ T* [(animals)-406.9(that)-406.9(were)-406.8(conditioned)-406.8(to)-406.8(the)-406.8(peppermint)]TJ T* [(odor)-224.7(\(Odor)-277.8(+)-277.7(Stroking\).)-224.7(\(*\))]TJ 8.98 0 1.746 8.98 175.33 393.1 Tm 0 Tw (P)Tj 8.98 0 0 8.98 182.817 393.1 Tm [(<)-277.7(0.05.)]TJ 8.98 0 1.746 8.98 212.742 393.1 Tm (N)Tj 8.98 0 0 8.98 222.222 393.1 Tm [(=)-277.7(6)-224.7(for)-224.7(each)]TJ -16.6708 -1.2222 TD (treatment.)Tj /F21 1 Tf 9.978 0 0 9.978 72.516 747.723 Tm [(McLean)-332.9(et)-332.9(al.)]TJ /F20 1 Tf 23.947 0 0 23.947 297.57 41.783 Tm 0 0 0 0 k BX /GS1 gs EX (&)Tj /F21 1 Tf 8.98 0 0 8.98 142.869 41.783 Tm 0 0 0 1 k BX /GS2 gs EX 1.5 Tc [(LEARNING)-4166.6(M)0.1(EMORY)]TJ /F22 1 Tf 11.974 0 0 11.974 295.824 25.818 Tm 0 0 0 0 k BX /GS1 gs EX 0 Tc (614)Tj ET 0 0 0 1 K 0 J 0 j 77.828 w 10 M []0 d BX /GS2 gs EX 288.04 22.825 m 288.289 22.825 l S 0.249 w 288.289 61.614 m 323.96 61.614 l S 77.828 w 323.711 22.825 m 323.96 22.825 l S endstream endobj 20 0 obj<> endobj 21 0 obj<>/ProcSet[/PDF/Text]/ExtGState<>>> endobj 22 0 obj<>stream 0 0 0 1 k BX /GS2 gs EX 1 i 288.04 -22.076 35.921 83.815 re f BT /F14 1 Tf 9.978 0 0 9.978 72.516 712.8 Tm 0 Tc [(numbers)-572.4(in)-572.4(the)-572.4(periglomerular)-572.4(region)-572.4(\(Cooper-)]TJ 0 -1.2 TD [(smith)-346.6(and)-346.6(Leon)-346.6(1986;)-346.6(Woo)-346.6(and)-346.6(Leon)-346.6(1987,)-346.6(1991;)]TJ T* [(Sullivan)-572.4(et)-572.4(al.)-572.4(1990,)-572.4(1991;)-572.4(Matsutani)-572.4(and)-572.4(Leon)]TJ T* [(1993;)-274.1(Johnson)-274.1(et)-274.1(al.)-274.1(1995\),)-274.1(the)-274.1(density)-274.1(of)-274.1(glial)-274.1(pro-)]TJ T* [(cesses)-284.9(in)-284.9(the)-284.9(glomeruli)-284.9(\()-100(Matsutani)-284.9(and)-284.9(Leon)-284.9(1993\))]TJ T* [(and)-243.2(the)-243.2(area)-243.2(of)-243.2(the)-243.2(glomerular)-243.2(neuropil)-243.2(\()-100(Woo)-243.2(et)-243.2(al.)]TJ T* [(1987)-100(\))-424.1(are)-424.1(all)-424.1(increased)-424.1(in)-424.1(pups)-424.1(that)-424.1(have)-424.1(under-)]TJ T* [(gone)-355.9(18)-355.9(days)-355.9(of)-356(conditioning)-355.9(procedures.)-356(The)-355.9(re-)]TJ T* [(sults)-318.7(from)-318.7(the)-318.7(present)-318.7(study,)-318.7(however,)-318.7(highlight)-318.7(a)]TJ T* [(role)-398.6(of)-398.6(mitral)-398.6(cell)-398.6(activation)-398.6(in)-398.6(the)-398.6(initial)-398.6(acquisi-)]TJ T* [(tion)-479.8(of)-479.8(conditioned)-479.8(preference)-479.8(to)-479.8(a)-479.8(novel)-479.8(odor.)]TJ T* [(Whether)-309.4(such)-309.3(activation)-309.3(leads)-309.4(to)-309.3(alterations)-309.4(in)-309.3(mi-)]TJ T* [(tral)-406.8(cell)-406.8(dendrites)-406.8(which)-406.8(might)-406.8(contribute)-406.8(to)-406.8(the)]TJ T* [(later)-389.2(observations)-389.2(of)-389.2(increases)-389.2(in)-389.2(glomerular)-389.2(neu-)]TJ T* [(ropil)-313.6(or)-313.6(periglomerular)-313.6(cells)-313.6(remains)-313.6(to)-313.6(be)-313.6(investi-)]TJ T* [(gated.)-337.5(It)-337.5(will)-337.5(be)-337.5(important)-337.5(to)-337.5(assess)-337.5(more)-337.5(directly)]TJ T* [(the)-448(relationship)-448(between)-448(odor)-448(input)-448(and)-448(pCREB)]TJ T* [(activation)-455.4(during)-455.4(acquisition)-455.4(by)-455.4(measuring)-455.4(meta-)]TJ T* [(bolic)-457.6(activation)-457.6(simultaneously)-457.6(using)-457.6(2-deoxyglu-)]TJ T* [(cose)-235.8(techniques)-235.8(and)-235.8(pCREB)-235.8(activation)-235.8(using)-235.8(immu-)]TJ T* [(noctytochemical)-367.3(techniques)-367.3(on)-367.3(sections)-367.3(from)-367.3(the)]TJ T* [(same)-332.9(subjects.)]TJ 1.8 -1.2 TD [(The)-395.4(pCREB)-395.4(changes)-395.4(in)-395.4(the)-395.4(present)-395.4(study)-395.4(are)]TJ -1.8 -1.2 TD [(widespread)-243.7(within)-243.7(the)-243.7(dorsolateral)-243.7(quadrant,)-243.7(a)-243.7(pat-)]TJ T* [(tern)-403.4(consistent)-403.4(with)-403.4(encoding)-403.4(changes)-403.4(occurring)]TJ T* [(throughout)-346.6(a)-346.6(neural)-346.6(network)-346.6(rather)-346.6(than)-346.6(at)-346.6(a)-346.6(few)]TJ T* [(hot)-219.6(spots)-219.6(within)-219.6(the)-219.6(olfactory)-219.6(bulb.)-219.6(Both)-219.6(excitatory)]TJ T* [(and)-317.9(inhibitory)-317.9(connections)-317.9(are)-317.9(likely)-317.9(to)-317.9(be)-317.9(altered)]TJ T* [(during)-444.3(learning)-444.3(\()-100(Wilson)-444.3(and)-444.3(Sullivan)-444.3(1990\))-444.3(so)-444.3(it)]TJ T* [(may)-272.7(not)-272.7(be)-272.7(surprising)-272.7(to)-272.7(have)-272.7(widespread)-272.7(regional)]TJ T* [(activation)-332.9(of)-332.9(CREB.)]TJ 8.98 0 0 8.98 72.516 324.159 Tm [(MONOAMINE)-443.8(INTERACTIONS)-443.8(IN)-443.8(CONDITIONED)]TJ 0 -1.3333 TD [(OLFACTORY)-443.8(LEARNING)]TJ 11.974 0 0 11.974 169.026 312.185 Tm 0 Tw (:)Tj 8.98 0 0 8.98 176.185 312.185 Tm [(POSSIBLE)-443.8(PCREB)-352.9(SYNERGY)]TJ 9.978 0 0 9.978 90.476 293.726 Tm [(Although)-220.4(noradrenergic)-220.4(input)-220.4(appears)-220.4(to)-220.4(act)-220.4(as)]TJ -1.8 -1.2 TD [(the)-507.6(critical)-507.7(unconditioned)-507.6(stimulus)-507.7(for)-507.7(olfactory)]TJ T* [(conditioned)-463.9(preference)-463.9(learning,)-463.9(we)-463.9(have)-463.9(found)]TJ T* [(that)-438.6(serotonergic)-438.6(depletion)-438.6(of)-438.6(the)-438.6(olfactory)-438.6(bulb)]TJ T* [(can)-404.5(prevent)-404.5(such)-404.5(learning.)-404.5(Our)-404.5(earlier)-404.5(work)-404.5(sug-)]TJ T* [(gests)-230.9(that)-230.9(5-HT)-230.9(acting)-230.9(through)-230.9(5-HT)]TJ 7.483 0 0 6.486 222.226 231.613 Tm (2)Tj 9.978 0 0 9.978 228.497 233.858 Tm [(receptors)-230.9(nor-)]TJ -15.6326 -1.2 TD [(mally)-502.5(promotes)-502.5(noradrenergic-induced)-502.5(plasticity.)]TJ T* [(Although)-342.3(sufficient)]TJ /F1 1 Tf 8.5582 0 TD (b)Tj /F14 1 Tf 0.9533 0 TD [(adrenoceptor)-342.3(activation)-342.3(can)]TJ -9.5115 -1.2 TD [(overcome)-330.1(the)-330.1(requirement)-330.1(for)-330.1(5-HT)]TJ 7.483 0 0 6.486 227.041 195.693 Tm (2)Tj 9.978 0 0 9.978 234.302 197.938 Tm [(input)-330.1(during)]TJ -16.2143 -1.2 TD [(olfactory)-769.6(preference)-769.6(learning)-769.6(\()-100(Langdon)-769.6(et)-769.6(al.)]TJ T* [(1997)-100(\),)-427.8(an)-427.8(increase)-427.8(of)-427.8(5-HT)]TJ 7.483 0 0 6.486 191.89 171.745 Tm (2)Tj 9.978 0 0 9.978 200.126 173.991 Tm [(stimulation)-427.8(can)-427.8(pro-)]TJ -12.7892 -1.2 TD [(duce)-424.1(learning)-424.1(with)-424.1(a)-424.1(subthreshold)-424.1(noradrenergic)]TJ T* [(stimulus)-286.3(\()-100(Price)-286.3(et)-286.3(al.)-286.4(1998\).)-286.4(5-HT)]TJ 7.483 0 0 6.486 213.975 147.798 Tm (2)Tj 9.978 0 0 9.978 220.798 150.043 Tm [(activation)-286.3(alone)]TJ -14.861 -1.2 TD [(does)-362.8(not)-362.8(seem)-362.7(to)-362.8(produce)-362.8(learning.)-362.8(These)-362.8(results)]TJ T* [(fit)-347.1(with)-347.1(the)-347.1(hypothesis)-347.1(that)-347.1(these)-347.1(two)-347.1(inputs)-347.1(may)]TJ T* [(act)-233.5(synergistically)-233.5(on)-233.5(the)-233.5(same)-233.5(cells)-233.5(with)-233.5(respect)-233.5(to)]TJ T* [(increasing)-311.3(cAMP.)-311.3(The)]TJ /F1 1 Tf 9.6516 0 TD (b)Tj /F14 1 Tf 0.611 0 TD [(1)-311.3(adrenoceptor)-311.3(is)-311.3(coupled)]TJ -10.2626 -1.2 TD [(to)-368.7(a)-368.7(G)-368.7(protein)-368.7(which,)-368.7(upon)-368.7(activation,)-368.7(stimulates)]TJ 25.2 62.4 TD [(adenyl)-262.8(cyclase)-262.8(induced)-262.8(cAMP)-262.8(production)-262.8(\(De)-262.8(Blasi)]TJ 0 -1.2 TD [(1989\).)-279.5(If)-279.5(cAMP-mediated)-279.5(long-term)-279.5(plasticity)-279.5(is)-279.5(the)]TJ T* [(substrate)-319.9(for)-319.9(olfactory)-319.9(preference)-319.9(learning,)-319.9(as)-319.9(sug-)]TJ T* [(gested)-243.4(by)-243.4(the)-243.4(present)-243.5(study,)-243.5(this)-243.4(would)-243.4(parallel)-243.5(the)]TJ T* [(role)-351.1(of)]TJ /F1 1 Tf 3.2191 0 TD (b)Tj /F14 1 Tf 0.9621 0 TD [(adrenoceptors)-351.1(and)-59.9(/)-59.9(o)0(r)-351.1(cAMP)-351.1(in)-351.1(the)-351.1(plas-)]TJ -4.1812 -1.2 TD [(ticity)-370.7(of)-370.7(the)-370.7(developing)-370.7(visual)-370.7(system)-370.7(\()-100(Kasamatsu)]TJ T* [(1983;)-220.2(Kasamatsu)-220.1(and)-220.1(Shirokawa)-220.1(1985\))-220.2(and)-220.1(in)-220.1(learn-)]TJ T* [(ing-related)-386.3(plasticity)-386.3(in)-386.3(a)-386.3(variety)-386.3(of)-386.3(biological)-386.4(sys-)]TJ T* [(tems)-330.9(\(Abrams)-330.9(et)-330.9(al.)-331(1991;)-330.9(Levin)-330.9(et)-330.9(al.)-331(1992;)-331(Frank)]TJ T* [(and)-363(Greenberg)-363(1994;)-363.1(Tully)-363(et)-363.1(al.)-363.1(1994\).)-363.1(Although)]TJ T* [(5-HT)-252.8(receptor)-252.8(activation)-252.8(does)-252.8(not)-252.8(by)-252.8(itself)-252.8(increase)]TJ T* [(cAMP)-238.3(expression)-238.3(\(Morin)-238.3(et)-238.3(al.)-238.3(1992\),)-238.3(which)-238.3(is)-238.3(con-)]TJ T* [(sistent)-512.5(with)-512.5(our)-512.5(failure)-512.5(to)-512.5(induce)-512.5(learning)-512.5(with)]TJ T* [(such)-587.8(activation)-587.8(alone,)-587.8(5-HT)]TJ 7.483 0 0 6.486 448.982 554.899 Tm (2)Tj 9.978 0 0 9.978 458.813 557.144 Tm [(activation)-587.7(can)-587.8(act)]TJ -13.5151 -1.2 TD [(through)-322.4(the)-322.4(phosphotidyl)-322.4(inositol)-322.4(second)-322.4(messen-)]TJ T* [(ger)-380.4(system)-380.4(to)-380.4(enhance)-380.4(the)-380.4(generation)-380.4(of)-380.4(intracel-)]TJ T* [(lular)-412.2(cAMP)-412.2(by)-412.2(isoproterenol)-412.2(or)-412.2(adenylate)-412.2(cyclase)]TJ T* [(\()-100(Rovescalli)-261.9(et)-261.9(al.)-261.9(1993\).)-261.9(It)-261.9(follows)-261.9(that)-261.9(serotonin)-261.9(in)]TJ T* [(the)-366.5(olfactory)-366.5(bulb)-366.4(might)-366.5(act)-366.5(to)-366.4(promote)-366.4(or)-366.5(inten-)]TJ T* [(sify)-559.1(the)-559.1(norepinephrine-induced)-559.1(cAMP)-559.1(uncondi-)]TJ T* [(tioned)-332.9(stimulus)-332.9(signal.)]TJ 1.8 -1.2 TD [(The)-263(present)-263.1(results)-263.1(suggest)-263.1(mitral)-263.1(cells)-263(may)-263(be)]TJ -1.8 -1.2 TD [(the)-372.1(critical)-372.1(cellular)-372.1(substrate)-372.1(for)-372.1(such)-372.1(interaction.)]TJ T* [(Other)-512.5(studies)-512.5(have)-512.5(shown)-512.5(that)-512.5(5-HT)]TJ 7.483 0 0 6.486 489.332 435.163 Tm (2A)Tj 9.978 0 0 9.978 503.03 437.408 Tm (receptor)Tj -17.9465 -1.2 TD [(mRNA)-324.4(\()-100(McLean)-324.4(et)-324.4(al.)-324.4(1995\))-324.4(and)-324.4(protein)-324.4(\()-100(Hamada)]TJ T* [(et)-280.1(al.)-280.1(1998\))-280.1(are)-280.1(localized)-280.1(in)-280.1(mitral)-59.9(/)-59.9(tufted)-280.1(cells)-280.1(and,)]TJ T* [(to)-537.2(a)-537.2(much)-537.2(lesser)-537.2(extent,)-537.2(in)-537.2(periglomerular)-537.2(and)]TJ T* [(granule)-338.6(cells)-338.6(\()-100(Hamada)-338.6(et)-338.6(al.)-338.6(1998\).)-338.6(Less)-338.6(is)-338.6(known)]TJ T* [(concerning)-357.4(the)-357.4(cellular)-357.4(localization)-357.4(of)-357.4(the)]TJ /F1 1 Tf 18.5674 0 TD (b)Tj /F14 1 Tf 0.9684 0 TD (adre-)Tj -19.5358 -1.2 TD [(noceptors,)-474.4(but)-474.4(one)-474.4(study)-474.4(has)-474.4(shown)-474.4(that)-474.4(mitral)]TJ T* [(cells)-391.2(and)-391.2(periglomerular)-391.2(cells)-391.2(express)]TJ /F1 1 Tf 16.8982 0 TD (b)Tj /F14 1 Tf 0.611 0 TD [(2)-391.2(adreno-)]TJ -17.5091 -1.2 TD [(ceptor)-428.4(mRNA)-428.4(in)-428.4(the)-428.4(neonate)-428.4(bulb)-428.4(\()-100(K.J.)-428.4(Ivins,)-428.4(E.)]TJ T* [(Ibrahim,)-249.4(and)-249.4(M.)-249.4(Leon,)-249.4(unpubl.\).)-249.4(Thus,)-249.4(it)-249.4(is)-249.4(possible)]TJ T* [(that)-513.1(both)-513(serotonergic)-513(and)-513(noradrenergic)-513(axons)]TJ T* [(act)-380.7(on)-380.6(mitral)-380.7(cells)-380.7(and)-59.9(/)-59.9(o)0(r)-380.7(interneurons)-380.7(to)-380.6(induce)]TJ T* [(learning)-380.4(by)-380.4(activating)-380.4(pCREB.)-380.4(It)-380.4(is)-380.4(less)-380.4(likely)-380.4(that)]TJ T* [(both)-311.6(act)-311.6(on)-311.6(periglomerular)-311.6(cells)-311.6(because)-311.6(very)-311.6(few)]TJ T* [(noradrenergic)-392.6(axons)-392.6(reach)-392.6(the)-392.6(periglomerular)-392.6(re-)]TJ T* [(gion)-552(\()-100(McLean)-552(and)-552(Shipley)-552(1991;)-552(McLean)-552(et)-552(al.)]TJ T* [(1989\).)-400(However,)-400(it)-400(should)-400(be)-400(noted)-400(that)-400(there)-400(is)]TJ T* [(relatively)-272.1(dense)]TJ /F1 1 Tf 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[(CREB)-383.2(in)-383.2(long-term)-383.2(plasticity)-383.2(was)-383.2(first)-383.2(reported)-383.2(in)]TJ T* [(cultured)-264.2(sensory)-264.2(and)-264.2(motor)-264.2(neurons)-264.2(of)]TJ /F17 1 Tf 16.8634 0 TD (Aplysia)Tj /F14 1 Tf 3.477 0 TD (ex-)Tj -20.3404 -1.2 TD [(posed)-342(to)-342(a)-342(serotonergic)-342(signal.)-342(It)-342(now)-342(appears,)-342(as)]TJ T* [(Brunelli)-503.7(et)-503.7(al.)-503.7(\(1976\))-503.7(hypothesized,)-503.7(that)-503.7(norepi-)]TJ T* [(nephrine)-534.1(functions)-534.1(in)-534.1(an)-534.1(analogous)-534.1(manner)-534.1(via)]TJ T* [(CREB)-347.7(activation)-347.7(to)-347.7(induce)-347.7(a)-347.7(long-term)-347.7(memory)-347.7(in)]TJ T* [(neonate)-332.9(rats.)]TJ ET 0 0 0 1 K 0 J 0 j 0.499 w 10 M []0 d 108.437 585.831 m 252.119 585.831 l S BT /F18 1 Tf 9.978 0 0 9.978 72.516 565.875 Tm (Acknowledgments)Tj /F19 1 Tf 7.982 0 0 7.982 90.476 555.398 Tm [(This)-332.7(work)-332.7(was)-332.7(supported)-332.7(by)-332.7(the)-332.7(M)0.1(edical)-332.7(R)0.1(esearch)]TJ -2.25 -1.25 TD -0.0001 Tc [(Council)-332.8(of)-332.8(Canada)-332.8(\(MT-14148\).)]TJ 2.25 -1.25 TD 0 Tc [(The)-332.7(publication)-332.7(costs)-332.7(of)-332.7(this)-332.7(article)-332.7(were)-332.7(d)0.1(efrayed)-332.7(in)]TJ -2.25 -1.25 TD [(part)-332.7(b)0.1(y)-332.7(p)0.1(ayment)-332.7(o)0.1(f)-332.7(p)0.1(age)-332.7(charges.)-332.7(This)-332.7(article)-332.7(must)-332.7(t)0(herefore)]TJ T* [(be)-332.7(hereby)-332.7(marked)-332.7(\252advertisement\272)-332.7(i)0(n)-332.7(accordance)-332.7(w)0.1(ith)-332.7(18)]TJ T* [(USC)-332.7(section)-332.7(1734)-332.7(solely)-332.7(to)-332.7(indicate)-332.7(this)-332.7(fact.)]TJ /F18 1 Tf 9.978 0 0 9.978 72.516 485.802 Tm (References)Tj /F19 1 Tf 7.982 0 0 7.982 72.516 475.325 Tm -0.0001 Tc [(Abel,)-332.8(T.)-332.8(and)-332.8(E.)-332.8(Kandel.)-332.8(1998.)-332.8(Positive)-332.8(and)-332.8(n)0(egative)]TJ T* 0 Tc [(regulatory)-332.7(mechanisms)-332.7(t)0(hat)-332.7(mediate)-332.7(long-term)-332.7(memory)]TJ T* (storage.)Tj 7.982 0 1.552 7.982 101.783 455.369 Tm [(Brain)-332.7(Res.)-332.7(R)0.1(ev.)]TJ /F18 1 Tf 7.982 0 0 7.982 157.201 455.369 Tm -0.0001 Tc (26:)Tj /F19 1 Tf 1.6679 0 TD (360\261378.)Tj -12.277 -2.5938 TD 0 Tc [(Abrams,)-332.7(T.W.,)-332.7(K)0.1(.A.)-332.7(Karl,)-332.7(and)-332.7(E)0.1(.R.)-332.7(K)0.1(andel.)-332.7(1991.)-332.7(Biochemical)]TJ 0 -1.25 TD [(studies)-332.7(of)-332.7(stimulus)-332.7(convergence)-332.7(during)-332.7(classical)-332.7(conditioning)]TJ T* (in)Tj 7.982 0 1.552 7.982 81.829 414.709 Tm (Aplysia)Tj 7.982 0 0 7.982 107.114 414.709 Tm [(:)-332.7(Dual)-332.7(regulation)-332.7(o)0.1(f)-332.7(a)0(denylate)-332.7(cyclase)-332.7(by)]TJ -4.3343 -1.25 TD -0.0001 Tc (Ca)Tj 5.987 0 0 4.989 81.83 407.974 Tm 0.0001 Tc (2+)Tj 7.982 0 0 7.982 89.145 404.731 Tm 0 Tc [(/)-59.6(c)0.1(almodulin)-332.7(and)-332.7(transmitter.)]TJ 7.982 0 1.552 7.982 190.295 404.731 Tm [(J.)-332.7(Neurosci.)]TJ /F18 1 Tf 7.982 0 0 7.982 72.516 394.753 Tm -0.0001 Tc (11:)Tj /F19 1 Tf 1.6679 0 TD (2655\2612665.)Tj -1.6679 -2.5938 TD [(Bartsch,)-332.8(D)0(.,)-332.8(A.)-332.8(Casadio,)-332.8(K.A.)-332.8(Karl,)-332.8(P.)-332.8(Serodio,)-332.8(and)-332.8(E.R.)]TJ 0 -1.25 TD [(Kandel.)-332.8(1998.)-332.8(CREB1)-332.8(encodes)-332.8(a)-332.8(nuclear)-332.8(activator,)-332.8(a)]TJ T* 0 Tc [(repressor,)-332.7(and)-332.7(a)-332.7(c)0.1(ytoplasmic)-332.7(modulator)-332.7(t)0(hat)-332.7(f)0(orm)-332.7(a)-332.7(regulatory)]TJ T* [(unit)-332.7(c)0.1(ritical)-332.7(for)-332.7(l)0(ong-term)-332.7(facilitation.)]TJ 7.982 0 1.552 7.982 203.788 344.115 Tm (Cell)Tj /F18 1 Tf 7.982 0 0 7.982 220.196 344.115 Tm -0.0001 Tc (95:)Tj /F19 1 Tf 1.6679 0 TD (211\261223.)Tj -20.1687 -2.5938 TD 0 Tc [(Berkowicz,)-332.7(D.A.,)-332.7(P)0.1(.Q.)-332.7(T)0.1(rombley,)-332.7(and)-332.7(G)0.1(.M.)-332.7(S)0(hepherd.)-332.7(1)0.1(994.)]TJ 0 -1.25 TD [(Evidence)-332.7(for)-332.7(glutamate)-332.7(a)0(s)-332.7(t)0(he)-332.7(olfactory)-332.7(receptor)-332.7(cell)]TJ T* (neurotransmitter.)Tj 7.982 0 1.552 7.982 133.717 303.454 Tm [(J.)-332.7(Neurophysiol.)]TJ /F18 1 Tf 7.982 0 0 7.982 192.266 303.454 Tm -0.0001 Tc (71:)Tj /F19 1 Tf 1.6679 0 TD (2557\2612561.)Tj -16.6697 -2.5938 TD [(Bito,)-332.8(H)0(.,)-332.8(K.)-332.8(Deisseroth,)-332.8(and)-332.8(R.W.)-332.8(Tsien.)-332.8(1996.)-332.8(CREB)]TJ 0 -1.25 TD [(phosphorylation)-332.8(and)-332.8(dephosphorylation:)-332.8(A)-332.8(C)0(a)]TJ 5.987 0 0 4.989 233.098 276.015 Tm 0.0001 Tc (2+)Tj 7.982 0 0 7.982 240.055 272.772 Tm 0.3327 Tc [(-a)332.7(n)332.8(d)]TJ -20.9887 -1.25 TD -0.0001 Tc [(stimulus)-332.8(duration-dependent)-332.8(switch)-332.8(for)-332.8(h)0(ippocampal)-332.8(gene)]TJ T* (expression.)Tj 7.982 0 1.552 7.982 113.763 252.816 Tm (Cell)Tj /F18 1 Tf 7.982 0 0 7.982 130.171 252.816 Tm (87:)Tj /F19 1 Tf 1.6679 0 TD (1203\2611214.)Tj -8.8907 -2.5938 TD [(Bozza,)-332.8(T)0(.C.)-332.8(a)-0.1(nd)-332.8(J.S.)-332.8(Kauer.)-332.8(1998.)-332.8(Odorant)-332.8(response)]TJ 0 -1.25 TD 0 Tc [(properties)-332.7(of)-332.7(convergent)-332.7(o)0.1(lfactory)-332.7(receptor)-332.7(n)0.1(eurons.)]TJ 7.982 0 1.552 7.982 255.674 222.134 Tm (J.)Tj -22.7024 -1.25 TD (Neurosci.)Tj /F18 1 Tf 7.982 0 0 7.982 108.439 212.156 Tm -0.0001 Tc (18:)Tj /F19 1 Tf 1.6679 0 TD (4560\2614569.)Tj -6.1682 -2.5938 TD 0 Tc [(Brunelli,)-332.7(M.,)-332.7(V)0.1(.)-332.7(Castellucci,)-332.7(and)-332.7(E)0.1(.R.)-332.7(K)0.1(andel.)-332.7(1976.)]TJ 0 -1.25 TD [(Presynaptic)-332.7(facilitation)-332.7(a)0(s)-332.7(a)-332.7(m)0.1(echanism)-332.7(for)-332.7(b)0.1(ehavioral)]TJ T* [(sensitization)-332.7(i)0(n)]TJ 7.982 0 1.552 7.982 127.074 171.496 Tm (Aplysia)Tj 7.982 0 0 7.982 152.36 171.496 Tm 0 Tw (.)Tj 7.982 0 1.552 7.982 157.235 171.496 Tm (Science)Tj /F18 1 Tf 7.982 0 0 7.982 186.501 171.496 Tm -0.0001 Tc (194:)Tj /F19 1 Tf 2.2239 0 TD (1176\2611180.)Tj -16.5035 -2.5937 TD [(Cirelli,)-332.8(C.,)-332.8(M)0(.)-332.8(Pompeiano,)-332.8(and)-332.8(G)0(.)-332.8(Tononi.)-332.8(1996.)-332.8(Neuronal)]TJ 0 -1.25 TD 0 Tc [(gene)-332.7(expression)-332.7(i)0(n)-332.7(t)0(he)-332.7(waking)-332.7(state:)-332.7(A)-332.7(r)0(ole)-332.7(f)0(or)-332.7(the)-332.7(l)0(ocus)]TJ T* -0.0001 Tc (coeruleus.)Tj 7.982 0 1.552 7.982 110.658 130.836 Tm 0 Tc (Science)Tj /F18 1 Tf 7.982 0 0 7.982 139.925 130.836 Tm -0.0001 Tc (274:)Tj /F19 1 Tf 2.2239 0 TD (1211\2611215.)Tj -10.6686 -2.5937 TD [(Coopersmith,)-332.8(R)0(.)-332.8(a)-0.1(nd)-332.8(M.)-332.8(Leon.)-332.8(1986.)-332.8(Enhanced)-332.8(n)0(eural)]TJ 0 -1.25 TD 0 Tc [(response)-332.7(b)0.1(y)-332.7(a)0(dult)-332.7(rats)-332.7(to)-332.7(odors)-332.7(experienced)-332.7(early)-332.7(in)-332.7(life.)]TJ 7.982 0 1.552 7.982 72.516 90.176 Tm [(Brain)-332.7(Res.)]TJ /F18 1 Tf 7.982 0 0 7.982 110.201 90.176 Tm -0.0001 Tc (371:)Tj /F19 1 Tf 2.2239 0 TD (400\261403.)Tj 24.5551 78.1875 TD 0 Tc [(De)-332.7(Blasi,)-332.7(A.)-332.7(1989.)-332.7(Advances)-332.7(on)-332.7(beta-adrenergic)-332.7(receptors:)]TJ 0 -1.25 TD [(Molecular)-332.7(structure)-332.7(and)-332.7(functional)-332.7(regulation.)]TJ 7.982 0 1.552 7.982 486.288 704.319 Tm -0.0001 Tc [(Am.)-332.8(J.)]TJ -20.0929 -1.25 TD 0 Tc (Hypertens.)Tj /F18 1 Tf 7.982 0 0 7.982 363.874 694.341 Tm (2:)Tj /F19 1 Tf 1.112 0 TD -0.0001 Tc (252S\261256S.)Tj -6.1122 -2.625 TD 0 Tc [(Deisseroth,)-332.7(K)0.1(.,)-332.7(H.)-332.7(Bito,)-332.7(a)0(nd)-332.7(R.W.)-332.7(Tsien.)-332.7(1)0.1(996.)-332.7(Signaling)-332.7(from)]TJ 0 -1.25 TD [(synapse)-332.7(t)0(o)-332.7(nucleus:)-332.7(Postsynaptic)-332.7(CREB)-332.7(phosphorylation)]TJ T* [(during)-332.7(multiple)-332.7(forms)-332.7(o)0.1(f)-332.7(h)0.1(ippocampal)-332.7(synaptic)-332.7(plasticity.)]TJ 7.982 0 1.552 7.982 323.96 643.453 Tm -0.0001 Tc (Neuron)Tj /F18 1 Tf 7.982 0 0 7.982 352.788 643.453 Tm (16:)Tj /F19 1 Tf 1.6679 0 TD (89\261101.)Tj -5.2793 -2.625 TD 0 Tc [(Deisseroth,)-332.7(K)0.1(.,)-332.7(E.K.)-332.7(Heist,)-332.7(and)-332.7(R)0.1(.W.)-332.7(T)0.1(sien.)-332.7(1998.)]TJ 0 -1.25 TD [(Translocation)-332.7(o)0.1(f)-332.7(c)0(almodulin)-332.7(to)-332.7(the)-332.7(nucleus)-332.7(s)0(upports)-332.7(CREB)]TJ T* [(phosphorylation)-332.7(in)-332.7(hippocampal)-332.7(n)0.1(eurons.)]TJ 7.982 0 1.552 7.982 472.115 602.544 Tm (Nature)Tj /F18 1 Tf 7.982 0 0 7.982 323.96 592.566 Tm -0.0001 Tc (392:)Tj /F19 1 Tf 2.2239 0 TD (198\261202.)Tj -2.2239 -2.625 TD 0 Tc [(Ennis,)-332.7(M.,)-332.7(L.A.)-332.7(Z)0.1(immer,)-332.7(and)-332.7(M)0.1(.T.)-332.7(S)0(hipley.)-332.7(1996.)-332.7(Olfactory)]TJ 0 -1.25 TD [(nerve)-332.7(stimulation)-332.7(activates)-332.7(rat)-332.7(mitral)-332.7(cells)-332.7(via)-332.7(NMDA)-332.7(and)]TJ T* [(non-NMDA)-332.7(receptors)-332.7(in)-332.7(vitro.)]TJ 7.982 0 1.552 7.982 431.281 551.656 Tm -0.0001 Tc (NeuroReport)Tj /F18 1 Tf 7.982 0 0 7.982 478.291 551.656 Tm (7:)Tj /F19 1 Tf 1.112 0 TD (989\261992.)Tj -20.4459 -2.6562 TD 0 Tc [(Frank,)-332.7(D.A.)-332.7(and)-332.7(M)0.1(.E.)-332.7(Greenberg.)-332.7(1994.)-332.7(CREB:)-332.7(A)-332.7(m)0.1(ediator)-332.7(o)0.1(f)]TJ 0 -1.25 TD [(long-term)-332.7(memory)-332.7(from)-332.7(mollusks)-332.7(t)0(o)-332.7(m)0.1(ammals.)]TJ 7.982 0 1.552 7.982 489.783 520.475 Tm (Cell)Tj /F18 1 Tf 7.982 0 0 7.982 506.191 520.475 Tm -0.0001 Tc (79:)Tj /F19 1 Tf 1.6679 0 TD (5\2618.)Tj -24.4971 -2.6562 TD [(Guthrie,)-332.8(K.M.)-332.8(and)-332.8(C)0(.M.)-332.8(Gall.)-332.8(1995a.)-332.8(Odors)-332.8(i)-0.1(ncrease)]TJ 7.982 0 1.552 7.982 510.22 499.272 Tm (fos)Tj 7.982 0 0 7.982 522.637 499.272 Tm 0 Tc (in)Tj -24.8895 -1.25 TD [(olfactory)-332.7(bulb)-332.7(n)0.1(eurons)-332.7(i)0(ncluding)-332.7(dopaminergic)-332.7(cells.)]TJ 7.982 0 1.552 7.982 323.96 479.316 Tm (NeuroReport)Tj /F18 1 Tf 7.982 0 0 7.982 370.97 479.316 Tm -0.0001 Tc (6:)Tj /F19 1 Tf 1.112 0 TD (2145\2612149.)Tj -7.0012 -2.6562 TD [(\320\320\320.)-332.8(1995b.)-332.8(Functional)-332.8(m)0(apping)-332.8(of)-332.8(odor-activated)]TJ 0 -1.25 TD 0 Tc [(neurons)-332.7(in)-332.7(the)-332.7(o)0.1(lfactory)-332.7(bulb.)]TJ 7.982 0 1.552 7.982 429.962 448.135 Tm [(Chem.)-332.7(Senses.)]TJ /F18 1 Tf 7.982 0 0 7.982 482.733 448.135 Tm -0.0001 Tc (20:)Tj /F19 1 Tf 1.6679 0 TD (271\261282.)Tj -21.5584 -2.6562 TD [(Guthrie,)-332.8(K.M.,)-332.8(A)0(.J.)-332.8(Anderson,)-332.8(M.)-332.8(Leon,)-332.8(and)-332.8(C)0(.)-332.8(G)0(all.)-332.8(1993.)]TJ 0 -1.25 TD 0 Tc [(Odor-induced)-332.7(increases)-332.7(in)-332.7(c-)]TJ 7.982 0 1.552 7.982 425.512 416.954 Tm -0.0001 Tc (fos)Tj 7.982 0 0 7.982 437.93 416.954 Tm 0 Tc [(mRNA)-332.7(expression)-332.7(reveal)-332.7(an)]TJ -14.2777 -1.25 TD [(anatomical)-332.7(\252unit\272)-332.7(for)-332.7(odor)-332.7(processing)-332.7(i)0(n)-332.7(o)0.1(lfactory)-332.7(bulb.)]TJ 7.982 0 1.552 7.982 519.981 406.976 Tm -0.0001 Tc (Proc.)Tj -24.3138 -1.25 TD 0 Tc [(Natl.)-332.7(Acad.)-332.7(Sci.)]TJ /F18 1 Tf 7.982 0 0 7.982 381.167 396.998 Tm -0.0001 Tc (90:)Tj /F19 1 Tf 1.6679 0 TD (3329\2613333.)Tj -8.8345 -2.6563 TD [(Hamada,)-332.8(S)0(.,)-332.8(K.)-332.8(Senzaki,)-332.8(K.)-332.8(Hamaguchi)-332.8(H)0(amada,)-332.8(K.)-332.8(Tabuchi,)]TJ 0 -1.25 TD [(H.)-332.8(Yamamoto,)-332.8(T.)-332.8(Yamamoto,)-332.8(S.)-332.8(Yoshikawa,)-332.8(H)0(.)-332.8(Okano,)-332.8(a)-0.1(nd)]TJ T* 0 Tc [(N.)-332.7(Okado.)-332.7(1998.)-332.7(Localization)-332.7(o)0.1(f)-332.7(5)0.1(-HT2A)-332.7(receptor)-332.7(i)0(n)-332.7(rat)]TJ T* [(cerebral)-332.7(cortex)-332.7(and)-332.7(o)0.1(lfactory)-332.7(system)-332.7(revealed)-332.7(by)]TJ T* [(immunohistochemistry)-332.7(using)-332.7(t)0(wo)-332.7(antibodies)-332.7(raised)-332.7(in)-332.7(rabbit)]TJ T* [(and)-332.7(c)0(hicken.)]TJ 7.982 0 1.552 7.982 371.415 325.905 Tm [(Mol.)-332.7(B)0.1(rain)-332.7(Res.)]TJ /F18 1 Tf 7.982 0 0 7.982 427.728 325.905 Tm -0.0001 Tc (54:)Tj /F19 1 Tf 1.6679 0 TD (199\261211.)Tj -14.6675 -2.6562 TD 0 Tc [(Impey,)-332.7(S.,)-332.7(M.)-332.7(Mark,)-332.7(E.C.)-332.7(V)0.1(illacres,)-332.7(S.)-332.7(Poser,)-332.7(C.)-332.7(Chavkin,)-332.7(a)0(nd)]TJ 0 -1.25 TD -0.0001 Tc [(D.R.)-332.8(Storm.)-332.8(1996.)-332.8(I)-0.1(nduction)-332.8(o)0(f)-332.8(CRE-mediated)-332.8(g)-0.1(ene)]TJ T* 0 Tc [(expression)-332.7(b)0(y)-332.7(stimuli)-332.7(that)-332.7(generate)-332.7(long-lasting)-332.7(L)0(TP)-332.7(in)-332.7(area)]TJ T* -0.0001 Tc [(CA1)-332.8(of)-332.8(the)-332.8(h)0(ippocampus.)]TJ 7.982 0 1.552 7.982 415.773 274.768 Tm (Neuron)Tj /F18 1 Tf 7.982 0 0 7.982 444.601 274.768 Tm (16:)Tj /F19 1 Tf 1.6679 0 TD (973\261982.)Tj -16.7813 -2.6562 TD [(Johnson,)-332.8(B.A.,)-332.8(C)0(.C.)-332.8(Woo,)-332.8(H.)-332.8(Duong,)-332.8(V)0(.)-332.8(Nguyen,)-332.8(and)-332.8(M.)]TJ 0 -1.25 TD [(Leon.)-332.8(1995.)-332.8(A)-332.8(l)-0.1(earned)-332.8(odor)-332.8(evokes)-332.8(a)-0.1(n)-332.8(enhanced)]TJ 7.982 0 1.552 7.982 496.922 243.587 Tm (fos)Tj 7.982 0 0 7.982 506.684 243.587 Tm 0 Tc (-like)Tj -22.8909 -1.25 TD [(glomerular)-332.7(response)-332.7(i)0(n)-332.7(t)0(he)-332.7(olfactory)-332.7(bulb)-332.7(o)0.1(f)-332.7(young)-332.7(rats.)]TJ 7.982 0 1.552 7.982 520.418 233.609 Tm -0.0001 Tc (Brain)Tj -24.3685 -1.25 TD 0 Tc (Res.)Tj /F18 1 Tf 7.982 0 0 7.982 340.808 223.631 Tm -0.0001 Tc (699:)Tj /F19 1 Tf 2.2239 0 TD (192\261200.)Tj -4.3344 -2.6562 TD 0 Tc [(Kasamatsu,)-332.7(T)0.1(.)-332.7(1983.)-332.7(Neuronal)-332.7(plasticity)-332.7(maintained)-332.7(by)-332.7(the)]TJ 0 -1.25 TD [(central)-332.7(norepinephrine)-332.7(system)-332.7(in)-332.7(the)-332.7(cat)-332.7(visual)-332.7(cortex.)]TJ 7.982 0 1.552 7.982 515.535 192.45 Tm -0.0001 Tc (Progr.)Tj -23.7568 -1.25 TD 0 Tc [(Psychbiol.)-332.7(Physiol.)-332.7(Psychol.)]TJ /F18 1 Tf 7.982 0 0 7.982 423.325 182.472 Tm -0.0001 Tc (10:)Tj /F19 1 Tf 1.6679 0 TD (1\261112.)Tj -14.116 -2.6563 TD [(Kasamatsu,)-332.8(T)0(.)-332.8(a)0(nd)-332.8(T.)-332.8(Shirokawa.)-332.8(1985.)-332.8(Involvement)-332.8(of)]TJ /F1 1 Tf 0 -1.25 TD 0 Tc (b)Tj /F19 1 Tf 0.6109 0 TD [(-adrenoreceptors)-332.7(in)-332.7(the)-332.7(s)0(hift)-332.7(of)-332.7(ocular)-332.7(dominance)-332.7(after)]TJ -0.6109 -1.25 TD [(monocular)-332.7(deprivation.)]TJ 7.982 0 1.552 7.982 407.787 141.313 Tm [(Exp.)-332.7(B)0.1(rain)-332.7(Res.)]TJ /F18 1 Tf 7.982 0 0 7.982 462.767 141.313 Tm -0.0001 Tc (59:)Tj /F19 1 Tf 1.6679 0 TD (507\261514.)Tj -19.0571 -2.6562 TD [(Langdon,)-332.8(P.E.,)-332.8(C.W.)-332.8(Harley,)-332.8(and)-332.8(J.H.)-332.8(M)0(cLean.)-332.8(1997.)]TJ 0 -1.25 TD 0 Tc (Increased)Tj /F1 1 Tf 4.4443 0 TD (b)Tj /F19 1 Tf 0.9437 0 TD [(adrenoceptor)-332.7(a)0.1(ctivation)-332.7(o)0.1(vercomes)-332.7(conditioned)]TJ -5.388 -1.25 TD [(olfactory)-332.7(learning)-332.7(d)0.1(eficits)-332.7(induced)-332.7(b)0.1(y)-332.7(serotonin)-332.7(depletion.)]TJ 7.982 0 1.552 7.982 323.96 90.176 Tm [(Dev.)-332.7(Brain)-332.7(Res.)]TJ /F18 1 Tf 7.982 0 0 7.982 380.712 90.176 Tm -0.0001 Tc (102:)Tj /F19 1 Tf 2.2239 0 TD (291\261293.)Tj /F21 1 Tf 9.978 0 0 9.978 72.516 747.723 Tm 0 Tc [(McLean)-332.9(et)-332.9(al.)]TJ /F20 1 Tf 23.947 0 0 23.947 297.57 41.783 Tm 0 0 0 0 k BX /GS1 gs EX (&)Tj /F21 1 Tf 8.98 0 0 8.98 142.869 41.783 Tm 0 0 0 1 k BX /GS2 gs EX 1.5 Tc [(LEARNING)-4166.6(M)0.1(EMORY)]TJ /F22 1 Tf 11.974 0 0 11.974 295.943 25.818 Tm 0 0 0 0 k BX /GS1 gs EX 0 Tc (616)Tj ET 77.828 w BX /GS2 gs EX 288.04 22.825 m 288.289 22.825 l S 0.249 w 288.289 61.614 m 323.96 61.614 l S 77.828 w 323.711 22.825 m 323.96 22.825 l S endstream endobj 26 0 obj<> endobj 27 0 obj<>/ProcSet[/PDF/Text]/ExtGState<>>> endobj 28 0 obj<>stream 0 0 0 1 k BX /GS2 gs EX 1 i 288.04 -22.076 35.921 83.815 re f BT /F19 1 Tf 7.982 0 0 7.982 72.516 714.297 Tm 0 Tc [(Levin,)-332.7(L.R.,)-332.7(P.)-332.7(Han,)-332.7(P.M.)-332.7(Hwang,)-332.7(P)0.1(.G.)-332.7(Feinstein,)-332.7(R)0.1(.L.)-332.7(Davis,)]TJ 0 -1.25 TD -0.0001 Tc [(and)-332.8(R.R.)-332.8(Reed.)-332.8(1992.)-332.8(The)]TJ 7.982 0 1.552 7.982 165.205 704.319 Tm (drosophila)Tj 7.982 0 0 7.982 204.241 704.319 Tm [(learning)-332.8(a)-0.1(nd)-332.8(memory)]TJ -16.502 -1.25 TD (gene)Tj 7.982 0 1.552 7.982 91.582 694.341 Tm (rutabaga)Tj 7.982 0 0 7.982 123.954 694.341 Tm [(encodes)-332.8(a)-332.8(C)0(a)]TJ 5.987 0 0 4.989 170.961 697.584 Tm 0.0001 Tc (2+)Tj 7.982 0 0 7.982 178.276 694.341 Tm 0 Tc [(/)-59.6(calmodulin-responsive)]TJ -13.2492 -1.25 TD -0.0001 Tc [(adenylyl)-332.8(cyclase.)]TJ 7.982 0 1.552 7.982 134.601 684.363 Tm 0 Tc (Cell)Tj /F18 1 Tf 7.982 0 0 7.982 151.009 684.363 Tm -0.0001 Tc (68:)Tj /F19 1 Tf 1.6679 0 TD (479\261489.)Tj -11.5013 -2.5312 TD [(Matsutani,)-332.8(S)0(.)-332.8(and)-332.8(M.)-332.8(Leon.)-332.8(1993.)-332.8(Elaboration)-332.8(o)0(f)-332.8(glial)-332.8(cell)]TJ 0 -1.25 TD 0 Tc [(processes)-332.7(in)-332.7(the)-332.7(r)0(at)-332.7(olfactory)-332.7(bulb)-332.7(associated)-332.7(w)0.1(ith)-332.7(early)]TJ T* -0.0001 Tc (learning.)Tj 7.982 0 1.552 7.982 105.334 644.202 Tm 0 Tc [(Brain)-332.7(Res.)]TJ /F18 1 Tf 7.982 0 0 7.982 143.02 644.202 Tm -0.0001 Tc (613:)Tj /F19 1 Tf 2.2239 0 TD (317\261320.)Tj -11.0563 -2.5312 TD 0 Tc [(Matthies,)-332.7(H.,)-332.7(S)0.1(.)-332.7(Schulz,)-332.7(W.)-332.7(Thiemann,)-332.7(H.)-332.7(Siemer,)-332.7(H.)]TJ 0 -1.25 TD 0.3327 Tc [(S)332.8(c)332.7(h)332.8(m)332.8(i)332.7(d)332.8(t)332.7(,M)332.8(.K)332.8(r)332.7(u)332.8(g)332.7(,)0(a)332.7(n)332.8(dV)332.8(.H)332.8(o)]TJ 12.3334 0 TD 0 Tc [(\310)-111.5(llt.)-332.7(1997.)-332.7(Design)-332.7(of)-332.7(a)-332.7(multiple)]TJ -12.3334 -1.25 TD -0.0001 Tc [(slice)-332.8(i)-0.1(nterface)-332.8(chamber)-332.8(and)-332.8(application)-332.8(f)-0.1(or)-332.8(resolving)-332.8(t)-0.1(he)]TJ T* 0 Tc [(temporal)-332.7(pattern)-332.7(of)-332.7(CREB)-332.7(phosphorylation)-332.7(i)0(n)-332.7(h)0.1(ippocampal)]TJ T* [(long-term)-332.7(potentiation.)]TJ 7.982 0 1.552 7.982 154.571 584.084 Tm -0.0001 Tc [(J.)-332.8(Neurosci.)-332.8(M)0(ethods)]TJ /F18 1 Tf 7.982 0 0 7.982 229.967 584.084 Tm (78:)Tj /F19 1 Tf 1.6679 0 TD (173\261179.)Tj -21.3928 -2.5312 TD [(McLean,)-332.8(J.H.)-332.8(and)-332.8(M.T.)-332.8(Shipley.)-332.8(1991.)-332.8(Postnatal)-332.8(d)0(evelopment)]TJ 0 -1.25 TD 0 Tc [(of)-332.7(the)-332.7(noradrenergic)-332.7(projection)-332.7(from)-332.7(l)0(ocus)-332.7(coeruleus)-332.7(t)0(o)-332.7(t)0(he)]TJ T* [(olfactory)-332.7(bulb)-332.7(i)0(n)-332.7(t)0(he)-332.7(rat.)]TJ 7.982 0 1.552 7.982 159.881 543.923 Tm -0.0001 Tc [(J.)-332.8(Comp.)-332.8(Neurol.)]TJ /F18 1 Tf 7.982 0 0 7.982 221.525 543.923 Tm (304:)Tj /F19 1 Tf 2.2239 0 TD (467\261477.)Tj -20.8912 -2.5312 TD 0 Tc [(McLean,)-332.7(J.H.,)-332.7(M.T.)-332.7(Shipley,)-332.7(W.T.)-332.7(Nickell,)-332.7(G.)-332.7(Aston-Jones,)]TJ 0 -1.25 TD -0.0001 Tc [(and)-332.8(C.K.)-332.8(Reyher.)-332.8(1989.)-332.8(Chemoanatomical)-332.8(organization)-332.8(o)0(f)-332.8(t)-0.1(he)]TJ T* 0 Tc [(noradrenergic)-332.7(input)-332.7(from)-332.7(l)0(ocus)-332.7(coeruleus)-332.7(t)0(o)-332.7(t)0(he)-332.7(olfactory)]TJ T* -0.0001 Tc [(bulb)-332.8(o)0(f)-332.8(t)-0.1(he)-332.8(adult)-332.8(rat.)]TJ 7.982 0 1.552 7.982 147.023 493.784 Tm [(J.)-332.8(Comp.)-332.8(Neurol.)]TJ /F18 1 Tf 7.982 0 0 7.982 208.667 493.784 Tm (285:)Tj /F19 1 Tf 2.2239 0 TD (339\261349.)Tj -19.2804 -2.5625 TD 0 Tc [(McLean,)-332.7(J.H.,)-332.7(A.)-332.7(Darby-King,)-332.7(R)0.1(.M.)-332.7(S)0(ullivan,)-332.7(a)0(nd)-332.7(S.R.)-332.7(K)0.1(ing.)]TJ 0 -1.25 TD [(1993.)-332.7(Serotonergic)-332.7(influence)-332.7(on)-332.7(olfactory)-332.7(learning)-332.7(i)0(n)-332.7(t)0(he)]TJ T* [(neonate)-332.7(rat.)]TJ 7.982 0 1.552 7.982 116.419 453.373 Tm -0.0001 Tc [(Behav.)-332.8(Neural)-332.8(Biol.)]TJ /F18 1 Tf 7.982 0 0 7.982 187.37 453.373 Tm (60:)Tj /F19 1 Tf 1.6679 0 TD (152\261162.)Tj -16.0564 -2.5625 TD [(McLean,)-332.8(J.H.,)-332.8(A.)-332.8(Darby-King,)-332.8(a)-0.1(nd)-332.8(G.)-332.8(Paterno.)-332.8(1995.)]TJ 0 -1.25 TD 0 Tc [(Localization)-332.7(o)0.1(f)-332.7(5)0.1(-HT)]TJ 5.987 0 0 4.989 144.37 421.194 Tm 0.0001 Tc (2A)Tj 7.982 0 0 7.982 154.349 422.94 Tm 0 Tc [(receptor)-332.7(mRNA)-332.7(by)-332.7(in)-332.7(situ)]TJ -10.2518 -1.25 TD [(hybridization)-332.7(i)0(n)-332.7(t)0(he)-332.7(olfactory)-332.7(bulb)-332.7(o)0.1(f)-332.7(t)0(he)-332.7(postnatal)-332.7(rat.)]TJ 7.982 0 1.552 7.982 264.56 412.962 Tm (J.)Tj -23.8156 -1.25 TD -0.0001 Tc [(Comp.)-332.8(Neurol.)]TJ /F18 1 Tf 7.982 0 0 7.982 127.066 402.985 Tm (353:)Tj /F19 1 Tf 2.2239 0 TD (371\261378.)Tj -9.0577 -2.5625 TD [(McLean,)-332.8(J.H.,)-332.8(A.)-332.8(Darby-King,)-332.8(a)-0.1(nd)-332.8(E.)-332.8(Hodge.)-332.8(1996.)-332.8(5-HT)]TJ 5.987 0 0 4.989 269.87 380.784 Tm 0 Tc 0 Tw (2)Tj 7.982 0 0 7.982 72.516 372.552 Tm [(receptor)-332.7(involvement)-332.7(in)-332.7(conditioned)-332.7(o)0.1(lfactory)-332.7(learning)-332.7(i)0(n)-332.7(t)0(he)]TJ 0 -1.25 TD -0.0001 Tc [(neonate)-332.8(rat)-332.8(pup.)]TJ 7.982 0 1.552 7.982 132.388 362.574 Tm [(Behav.)-332.8(Neurosci.)]TJ /F18 1 Tf 7.982 0 0 7.982 194.473 362.574 Tm (110:)Tj /F19 1 Tf 2.2239 0 TD (1426\2611434.)Tj -17.5022 -2.5625 TD 0 Tc [(Michael,)-332.7(D.,)-332.7(K)0.1(.C.)-332.7(Martin,)-332.7(R)0.1(.)-332.7(S)0(eger,)-332.7(M.M.)-332.7(Ning,)-332.7(R)0.1(.)-332.7(B)0.1(aston,)]TJ 0 -1.25 TD -0.0001 Tc [(and)-332.8(E.R.)-332.8(Kandel.)-332.8(1998.)-332.8(Repeated)-332.8(pulses)-332.8(of)-332.8(serotonin)-332.8(required)]TJ T* 0 Tc [(for)-332.7(l)0(ong-term)-332.7(facilitation)-332.7(activate)-332.7(mitogen-activated)-332.7(protein)]TJ T* [(kinase)-332.7(in)-332.7(sensory)-332.7(neurons)-332.7(of)]TJ 7.982 0 1.552 7.982 174.072 312.185 Tm (Aplysia)Tj 7.982 0 0 7.982 199.358 312.185 Tm (.)Tj 7.982 0 1.552 7.982 204.233 312.185 Tm [(Proc.)-332.7(N)0.1(atl.)-332.7(Acad.)-332.7(Sci.)]TJ /F18 1 Tf 7.982 0 0 7.982 72.516 302.207 Tm -0.0001 Tc (95:)Tj /F19 1 Tf 1.6679 0 TD (1864\2611869.)Tj -1.6679 -2.5625 TD [(Moore,)-332.8(A.N.,)-332.8(M)0(.N.)-332.8(W)0(axham,)-332.8(and)-332.8(P.K.)-332.8(Dash.)-332.8(1996.)-332.8(Neuronal)]TJ 0 -1.25 TD 0 Tc [(activity)-332.7(increases)-332.7(the)-332.7(phosphorylation)-332.7(o)0.1(f)-332.7(t)0(he)-332.7(transcription)]TJ T* [(factor)-332.7(c)0(AMP)-332.7(response)-332.7(e)0.1(lement-binding)-332.7(protein)-332.7(\(CREB\))-332.7(in)-332.7(rat)]TJ T* -0.0001 Tc [(hippocampus)-332.8(and)-332.8(cortex.)]TJ 7.982 0 1.552 7.982 163.437 251.819 Tm [(J.)-332.8(Biol.)-332.8(Chem.)]TJ /F18 1 Tf 7.982 0 0 7.982 214.433 251.819 Tm (271:)Tj /F19 1 Tf 2.2239 0 TD (14214\26114220.)Tj -20.0027 -2.5625 TD [(Morin,)-332.8(D)0(.,)-332.8(R.)-332.8(Sapena,)-332.8(R.)-332.8(Zini,)-332.8(a)-0.1(nd)-332.8(J.-P.)-332.8(T)0(illement.)-332.8(1992.)]TJ 0 -1.25 TD [(Serotonin)-332.8(e)-0.1(nhances)-332.8(the)]TJ /F1 1 Tf 10.5013 0 TD 0 Tc (b)Tj /F19 1 Tf 0.6109 0 TD [(-adrenergic)-332.7(response)-332.7(i)0(n)-332.7(rat)-332.7(brain)]TJ -11.1122 -1.25 TD [(cortical)-332.7(slices.)]TJ 7.982 0 1.552 7.982 124.4 211.408 Tm [(Eur.)-332.7(J.)-332.7(Pharmacol.)]TJ /F18 1 Tf 7.982 0 0 7.982 189.142 211.408 Tm -0.0001 Tc (225:)Tj /F19 1 Tf 2.2239 0 TD (273\261274.)Tj -16.8343 -2.5625 TD 0 Tc [(Nakamura,)-332.7(S.,)-332.7(K.)-332.7(Fumitaka,)-332.7(and)-332.7(T)0.1(.)-332.7(Sakaguchi.)-332.7(1987.)]TJ 0 -1.25 TD [(Postnatal)-332.7(d)0.1(evelopment)-332.7(of)-332.7(electrical)-332.7(activity)-332.7(in)-332.7(the)-332.7(l)0(ocus)]TJ T* (ceruleus.)Tj 7.982 0 1.552 7.982 106.22 170.997 Tm [(J.)-332.7(Neurophysiol.)]TJ /F18 1 Tf 7.982 0 0 7.982 164.769 170.997 Tm -0.0001 Tc (58:)Tj /F19 1 Tf 1.6679 0 TD (510\261524.)Tj -13.2251 -2.5625 TD 0 Tc [(Nigg,)-332.7(E.A.,)-332.7(H.)-332.7(Hilz,)-332.7(H.M.)-332.7(Eppenberger,)-332.7(and)-332.7(F)0(.)-332.7(Dutly.)-332.7(1985.)]TJ 0 -1.25 TD [(Rapid)-332.7(and)-332.7(reversible)-332.7(translocation)-332.7(o)0.1(f)-332.7(t)0(he)-332.7(catalytic)-332.7(subunit)-332.7(o)0.1(f)]TJ T* [(cAMP-dependent)-332.7(protein)-332.7(kinase)-332.7(type)-332.7(I)0(I)-332.7(from)-332.7(t)0(he)-332.7(Golgi)]TJ T* -0.0001 Tc [(complex)-332.8(to)-332.8(the)-332.8(nucleus.)]TJ 7.982 0 1.552 7.982 158.997 120.608 Tm [(EMBO)-332.8(J.)]TJ /F18 1 Tf 7.982 0 0 7.982 191.359 120.608 Tm (4:)Tj /F19 1 Tf 1.112 0 TD (2801\2612806.)Tj -16.0001 -2.5625 TD 0 Tc [(Price,)-332.7(T)0.1(.L.,)-332.7(A.)-332.7(Darby-King,)-332.7(C.W.)-332.7(Harley,)-332.7(and)-332.7(J.H.)-332.7(M)0.1(cLean.)]TJ 0 -1.25 TD -0.0001 Tc [(1998.)-332.8(Serotonin)-332.8(p)0(lays)-332.8(a)-332.8(permissive)-332.8(r)-0.1(ole)-332.8(i)-0.1(n)-332.8(c)-0.1(onditioned)]TJ 31.5 78.1875 TD 0 Tc [(olfactory)-332.7(learning)-332.7(i)0(nduced)-332.7(b)0.1(y)-332.7(norepinephrine)-332.7(i)0(n)-332.7(t)0(he)-332.7(neonate)]TJ 0 -1.25 TD (rat.)Tj 7.982 0 1.552 7.982 337.703 704.319 Tm [(Behav.)-332.7(Neurosci.)]TJ /F18 1 Tf 7.982 0 0 7.982 399.788 704.319 Tm -0.0001 Tc (112:)Tj /F19 1 Tf 2.2239 0 TD (1430\2611437.)Tj -11.7232 -2.625 TD 0 Tc [(Rovescalli,)-332.7(A.C.,)-332.7(N)0.1(.)-332.7(B)0.1(runello,)-332.7(J.)-332.7(Perez,)-332.7(S.)-332.7(Vitali,)-332.7(L.)-332.7(Steardo,)]TJ 0 -1.25 TD [(and)-332.7(G)0.1(.)-332.7(R)0.1(acagni.)-332.7(1993.)-332.7(Heterologous)-332.7(sensitization)-332.7(o)0(f)]TJ T* [(adenylate)-332.7(cyclase)-332.7(activity)-332.7(by)-332.7(serotonin)-332.7(in)-332.7(the)-332.7(rat)-332.7(cerebral)]TJ T* (cortex.)Tj 7.982 0 1.552 7.982 350.122 653.431 Tm [(Eur.)-332.7(Neuropsychopharmacol.)]TJ /F18 1 Tf 7.982 0 0 7.982 453.903 653.431 Tm -0.0001 Tc (3:)Tj /F19 1 Tf 1.112 0 TD (463\261475.)Tj -17.3907 -2.625 TD 0 Tc [(Sakaguchi,)-332.7(H.,)-332.7(K)0.1(.)-332.7(W)0.1(ada,)-332.7(M.)-332.7(Maekawa,)-332.7(T)0.1(.)-332.7(W)0.1(atsuji,)-332.7(and)-332.7(M)0.1(.)]TJ 0 -1.25 TD -0.0001 Tc [(Hagiwara.)-332.8(1999.)-332.8(Song-induced)-332.8(phosphorylation)-332.8(o)0(f)-332.8(c)-0.1(AMP)]TJ T* 0 Tc [(response)-332.7(element-binding)-332.7(protein)-332.7(in)-332.7(the)-332.7(s)0(ongbird)-332.7(brain.)]TJ 7.982 0 1.552 7.982 520.438 612.522 Tm (J.)Tj -24.371 -1.25 TD (Neurosci.)Tj /F18 1 Tf 7.982 0 0 7.982 359.884 602.544 Tm -0.0001 Tc (19:)Tj /F19 1 Tf 1.6679 0 TD (3973\2613981.)Tj -6.1682 -2.625 TD 0 Tc [(Schwab,)-332.7(M.E.)-332.7(1996.)-332.7(Structural)-332.7(plasticity)-332.7(of)-332.7(the)-332.7(a)0(dult)-332.7(CNS.)]TJ 0 -1.25 TD [(Negative)-332.7(control)-332.7(b)0(y)-332.7(n)0.1(eurite)-332.7(growth)-332.7(i)0(nhibitory)-332.7(signals.)]TJ 7.982 0 1.552 7.982 512.448 571.612 Tm [(Int.)-332.7(J.)]TJ -23.3701 -1.25 TD [(Dev.)-332.7(Neurosci.)]TJ /F18 1 Tf 7.982 0 0 7.982 378.95 561.634 Tm -0.0001 Tc (14:)Tj /F19 1 Tf 1.6679 0 TD (379\261385.)Tj -8.5568 -2.625 TD 0 Tc [(Silva,)-332.7(A.J.,)-332.7(J.H.)-332.7(Kogan,)-332.7(P)0.1(.W.)-332.7(Frankland,)-332.7(and)-332.7(S)0.1(.)-332.7(K)0.1(ida.)-332.7(1998.)]TJ 0 -1.25 TD -0.0001 Tc [(CREB)-332.8(a)-0.1(nd)-332.8(memory.)]TJ 7.982 0 1.552 7.982 394.456 530.702 Tm [(Annu.)-332.8(Rev.)-332.8(Neurosci.)]TJ /F18 1 Tf 7.982 0 0 7.982 471.624 530.702 Tm (21:)Tj /F19 1 Tf 1.6679 0 TD (127\261148.)Tj -20.1667 -2.625 TD [(Sullivan,)-332.8(R)0(.M.)-332.8(a)-0.1(nd)-332.8(W.G.)-332.8(Hall.)-332.8(1988.)-332.8(Reinforcers)-332.8(in)-332.8(infancy:)]TJ 0 -1.25 TD 0 Tc [(Classical)-332.7(conditioning)-332.7(using)-332.7(stroking)-332.7(o)0.1(r)-332.7(i)0(ntra-oral)-332.7(infusions)-332.7(o)0.1(f)]TJ T* [(milk)-332.7(as)-332.7(UCS.)]TJ 7.982 0 1.552 7.982 371.844 489.793 Tm [(Dev.)-332.7(Psychobiol.)]TJ /F18 1 Tf 7.982 0 0 7.982 433.498 489.793 Tm -0.0001 Tc (21:)Tj /F19 1 Tf 1.6679 0 TD (215\261223.)Tj -15.3904 -2.625 TD 0 Tc [(Sullivan,)-332.7(R)0.1(.M.)-332.7(a)0(nd)-332.7(M.)-332.7(Leon.)-332.7(1986a.)-332.7(Early)-332.7(olfactory)-332.7(learning)]TJ 0 -1.25 TD [(induces)-332.7(an)-332.7(enhanced)-332.7(olfactory)-332.7(bulb)-332.7(response)-332.7(i)0(n)-332.7(young)-332.7(rats.)]TJ 7.982 0 1.552 7.982 323.96 448.883 Tm [(Dev.)-332.7(Brain)-332.7(Res.)]TJ /F18 1 Tf 7.982 0 0 7.982 380.712 448.883 Tm -0.0001 Tc (27:)Tj /F19 1 Tf 1.6679 0 TD (278\261282.)Tj -8.7775 -2.625 TD [(\320\320\320.)-332.8(1986b.)-332.8(Early)-332.8(olfactory)-332.8(learning)-332.8(i)-0.1(nduces)-332.8(a)-0.1(n)-332.8(e)-0.1(nhanced)]TJ 0 -1.25 TD 0 Tc [(olfactory)-332.7(bulb)-332.7(response)-332.7(i)0(n)-332.7(y)0(oung)-332.7(rats.)]TJ 7.982 0 1.552 7.982 457.896 417.951 Tm -0.0001 Tc [(Brain)-332.8(Res.)]TJ /F18 1 Tf 7.982 0 0 7.982 323.96 407.974 Tm (392:)Tj /F19 1 Tf 2.2239 0 TD (278\261282.)Tj -2.2239 -2.625 TD [(\320\320\320.)-332.8(1987.)-332.8(One-trial)-332.8(olfactory)-332.8(learning)-332.8(e)-0.1(nhances)-332.8(olfactory)]TJ 0 -1.25 TD 0 Tc [(bulb)-332.7(responses)-332.7(to)-332.7(an)-332.7(appetitive)-332.7(conditioned)-332.7(odor)-332.7(in)]TJ T* [(7-day-old)-332.7(rats.)]TJ 7.982 0 1.552 7.982 376.731 367.064 Tm [(Dev.)-332.7(Brain)-332.7(Res.)]TJ /F18 1 Tf 7.982 0 0 7.982 433.482 367.064 Tm -0.0001 Tc (35:)Tj /F19 1 Tf 1.6679 0 TD (307\261311.)Tj -15.3884 -2.6562 TD [(Sullivan,)-332.8(R)0(.M.,)-332.8(D.A.)-332.8(Wilson,)-332.8(and)-332.8(M)0(.H.)-332.8(K)0(im.)-332.8(1988.)]TJ 0 -1.25 TD 0 Tc [(Behavioral)-332.7(and)-332.7(n)0.1(eural)-332.7(correlates)-332.7(of)-332.7(postnatal)-332.7(olfactory)]TJ T* [(conditioning:)-332.7(I)0(.)-332.7(Effect)-332.7(o)0.1(f)-332.7(respiration)-332.7(o)0.1(n)-332.7(c)0(onditioned)-332.7(neural)]TJ T* (responses.)Tj 7.982 0 1.552 7.982 362.102 315.927 Tm [(Physiol.)-332.7(Behav.)]TJ /F18 1 Tf 7.982 0 0 7.982 417.986 315.927 Tm -0.0001 Tc (44:)Tj /F19 1 Tf 1.6679 0 TD (85\26190.)Tj -13.4471 -2.6562 TD [(Sullivan,)-332.8(R)0(.M.,)-332.8(D.A.)-332.8(Wilson,)-332.8(and)-332.8(M)0(.)-332.8(L)-0.1(eon.)-332.8(1989a.)]TJ 0 -1.25 TD 0 Tc [(Norepinephrine)-332.7(a)0(nd)-332.7(learning-induced)-332.7(plasticity)-332.7(in)-332.7(infant)-332.7(rat)]TJ T* [(olfactory)-332.7(sytem.)]TJ 7.982 0 1.552 7.982 381.608 274.768 Tm [(J.)-332.7(Neurosci.)]TJ /F18 1 Tf 7.982 0 0 7.982 424.625 274.768 Tm -0.0001 Tc (9:)Tj /F19 1 Tf 1.112 0 TD (3998\2614006.)Tj -13.7228 -2.6562 TD 0 Tc [(\320\320\320.)-332.7(1989b.)-332.7(Associative)-332.7(processes)-332.7(in)-332.7(early)-332.7(olfactory)]TJ 0 -1.25 TD [(preference)-332.7(acquisition:)-332.7(Neural)-332.7(and)-332.7(b)0.1(ehavioral)-332.7(consequences.)]TJ 7.982 0 1.552 7.982 323.96 233.609 Tm -0.0001 Tc (Psychobiology)Tj /F18 1 Tf 7.982 0 0 7.982 376.749 233.609 Tm (17:)Tj /F19 1 Tf 1.6679 0 TD (29\26133.)Tj -8.281 -2.6563 TD [(Sullivan,)-332.8(R)0(.M.,)-332.8(D.A.)-332.8(Wilson,)-332.8(R.)-332.8(Wong,)-332.8(A)0(.)-332.8(Correa,)-332.8(and)-332.8(M)0(.)]TJ 0 -1.25 TD 0 Tc [(Leon.)-332.7(1990.)-332.7(Modified)-332.7(behavioral)-332.7(and)-332.7(o)0.1(lfactory)-332.7(bulb)]TJ T* [(responses)-332.7(to)-332.7(maternal)-332.7(odors)-332.7(i)0(n)-332.7(p)0.1(reweaning)-332.7(rats.)]TJ 7.982 0 1.552 7.982 492.918 192.45 Tm [(Dev.)-332.7(B)0.1(rain)]TJ -20.9233 -1.25 TD (Res.)Tj /F18 1 Tf 7.982 0 0 7.982 340.808 182.472 Tm -0.0001 Tc (53:)Tj /F19 1 Tf 1.6679 0 TD (243\261247.)Tj -3.7785 -2.6563 TD 0 Tc [(Sullivan,)-332.7(R)0.1(.M.,)-332.7(J.L.)-332.7(McGaugh,)-332.7(a)0(nd)-332.7(M.)-332.7(Leon.)-332.7(1991.)]TJ 0 -1.25 TD [(Norepinephrine-induced)-332.7(plasticity)-332.7(and)-332.7(one-trial)-332.7(o)0.1(lfactory)]TJ T* [(learning)-332.7(i)0(n)-332.7(n)0(eonatal)-332.7(rats.)]TJ 7.982 0 1.552 7.982 413.099 141.313 Tm [(Dev.)-332.7(Brain)-332.7(Res.)]TJ /F18 1 Tf 7.982 0 0 7.982 469.851 141.313 Tm -0.0001 Tc (60:)Tj /F19 1 Tf 1.6679 0 TD (219\261228.)Tj -19.9445 -2.6562 TD 0 Tc [(Tao,)-332.7(X.,)-332.7(S)0(.)-332.7(Finkbeiner,)-332.7(D.B.)-332.7(Arnold,)-332.7(A.J.)-332.7(Shaywitz,)-332.7(and)-332.7(M)0.1(.E.)]TJ 0 -1.25 TD -0.0001 Tc [(Greenberg.)-332.8(1998.)-332.8(Ca)]TJ 5.987 0 0 4.989 397.14 113.375 Tm 0.0001 Tc (2+)Tj 7.982 0 0 7.982 406.753 110.132 Tm 0 Tc [(influx)-332.7(regulates)-332.7(BDNF)-332.7(transcription)]TJ -10.372 -1.25 TD [(by)-332.7(a)-332.7(CREB)-332.7(family)-332.7(transcription)-332.7(factor-dependent)-332.7(mechanism.)]TJ 7.982 0 1.552 7.982 323.96 90.176 Tm -0.0001 Tc (Neuron)Tj /F18 1 Tf 7.982 0 0 7.982 352.788 90.176 Tm (20:)Tj /F19 1 Tf 1.6679 0 TD (709\261726.)Tj /F21 1 Tf 9.978 0 0 9.978 290.625 747.723 Tm 0 Tc [(CREB)-332.9(PHOSPHORYLATION)-332.9(IN)-332.9(ODOR-STROKE)-332.9(PAIRING)]TJ /F20 1 Tf 23.947 0 0 23.947 297.57 41.783 Tm 0 0 0 0 k BX /GS1 gs EX (&)Tj /F21 1 Tf 8.98 0 0 8.98 142.869 41.783 Tm 0 0 0 1 k BX /GS2 gs EX 1.5 Tc [(LEARNING)-4166.6(M)0.1(EMORY)]TJ /F22 1 Tf 11.974 0 0 11.974 295.943 25.818 Tm 0 0 0 0 k BX /GS1 gs EX 0 Tc (617)Tj ET 0 0 0 1 K 0 J 0 j 77.828 w 10 M []0 d BX /GS2 gs EX 288.04 22.825 m 288.289 22.825 l S 0.249 w 288.289 61.614 m 323.96 61.614 l S 77.828 w 323.711 22.825 m 323.96 22.825 l S endstream endobj 29 0 obj<> endobj 30 0 obj<>/ProcSet[/PDF/Text]/ExtGState<>>> endobj 31 0 obj<>stream 0 0 0 1 k BX /GS2 gs EX 1 i 288.04 -22.076 35.921 83.815 re f BT /F19 1 Tf 7.982 0 0 7.982 72.516 714.297 Tm 0 Tc [(Tully,)-332.7(T.)-332.7(1996.)-332.7(Discovery)-332.7(of)-332.7(genes)-332.7(involved)-332.7(with)-332.7(learning)]TJ 0 -1.25 TD [(and)-332.7(memory:)-332.7(An)-332.7(experimental)-332.7(synthesis)-332.7(of)-332.7(Hirschian)-332.7(and)]TJ T* [(Benzerian)-332.7(p)0.1(erspectives.)]TJ 7.982 0 1.552 7.982 156.774 694.341 Tm [(Proc.)-332.7(Natl.)-332.7(Acad.)-332.7(Sci.)]TJ /F18 1 Tf 7.982 0 0 7.982 72.516 684.363 Tm -0.0001 Tc (93:)Tj /F19 1 Tf 1.6679 0 TD (13460\26113467.)Tj -1.6679 -2.5 TD [(Tully,)-332.8(T.,)-332.8(T)0(.)-332.8(P)0(reat,)-332.8(S.C.)-332.8(Boynton,)-332.8(and)-332.8(M)0(.)-332.8(D)0(el)-332.8(Vecchio.)-332.8(1994.)]TJ 0 -1.25 TD 0 Tc [(Genetic)-332.7(dissection)-332.7(o)0.1(f)-332.7(consolidated)-332.7(memory)-332.7(i)0(n)]TJ 7.982 0 1.552 7.982 235.281 654.429 Tm -0.0001 Tc (Drosophila)Tj 7.982 0 0 7.982 273.433 654.429 Tm 0 Tc 0 Tw (.)Tj 7.982 0 1.552 7.982 72.516 644.451 Tm (Cell)Tj /F18 1 Tf 7.982 0 0 7.982 88.924 644.451 Tm -0.0001 Tc (79:)Tj /F19 1 Tf 1.6679 0 TD [(35\261)-125(47.)]TJ -3.7235 -2.5 TD 0 Tc [(Wilson,)-332.7(D.A.)-332.7(and)-332.7(R)0.1(.M.)-332.7(S)0(ullivan.)-332.7(1990.)-332.7(Olfactory)-332.7(associative)]TJ 0 -1.25 TD [(conditioning)-332.7(in)-332.7(infant)-332.7(rats)-332.7(with)-332.7(brain)-332.7(stimulation)-332.7(a)0(s)-332.7(reward.)-332.7(I)0(.)]TJ T* -0.0001 Tc [(Neurobehavioral)-332.8(consequences.)]TJ 7.982 0 1.552 7.982 186.505 604.539 Tm 0 Tc [(Dev.)-332.7(Brain)-332.7(Res.)]TJ /F18 1 Tf 7.982 0 0 7.982 72.516 594.561 Tm -0.0001 Tc (53:)Tj /F19 1 Tf 1.6679 0 TD (215\261221.)Tj -1.6679 -2.5 TD [(\320\320\320.)-332.8(1991.)-332.8(Olfactory)-332.8(associative)-332.8(conditioning)-332.8(in)-332.8(infant)]TJ 0 -1.25 TD 0 Tc [(rats)-332.7(with)-332.7(brain)-332.7(stimulation)-332.7(a)0(s)-332.7(reward:)-332.7(II.)-332.7(Norepinephrine)]TJ T* [(mediates)-332.7(a)-332.7(s)0(pecific)-332.7(component)-332.7(of)-332.7(the)-332.7(bulb)-332.7(response)-332.7(t)0(o)]TJ T* -0.0001 Tc (reward.)Tj 7.982 0 1.552 7.982 101.336 544.671 Tm 0 Tc [(Behav.)-332.7(N)0.1(eurosci.)]TJ /F18 1 Tf 7.982 0 0 7.982 163.421 544.671 Tm -0.0001 Tc (105:)Tj /F19 1 Tf 2.2239 0 TD (843\261849.)Tj -13.6121 -2.5 TD [(Woo,)-332.8(C.C.)-332.8(and)-332.8(M)0(.)-332.8(L)0(eon.)-332.8(1987.)-332.8(Sensitive)-332.8(period)-332.8(f)-0.1(or)-332.8(neural)]TJ 0 -1.25 TD [(and)-332.8(behavioral)-332.8(response)-332.8(development)-332.8(to)-332.8(learned)-332.8(odors.)]TJ 7.982 0 1.552 7.982 268.986 514.738 Tm 0 Tc (Dev.)Tj -24.37 -1.25 TD [(Brain)-332.7(Res.)]TJ /F18 1 Tf 7.982 0 0 7.982 110.201 504.76 Tm -0.0001 Tc (36:)Tj /F19 1 Tf 1.6679 0 TD (309\261313.)Tj -6.389 -2.5 TD [(\320\320\320.)-332.8(1991.)-332.8(Increase)-332.8(in)-332.8(a)-332.8(f)-0.1(ocal)-332.8(population)-332.8(o)0(f)]TJ 0 -1.25 TD 0 Tc [(juxtaglomerular)-332.7(cells)-332.7(in)-332.7(the)-332.7(o)0.1(lfactory)-332.7(bulb)-332.7(associated)-332.7(with)]TJ T* [(early)-332.7(learning.)]TJ 7.982 0 1.552 7.982 124.839 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Yc"5 ["(ޟXgU!Vɝ+n+f}8QE *P0M*R@xXC^#u/^-DI3=s8!2/ٙӵE?s7Ų+OU{K?@m0 9e%a&;3V7l_ŢB(@6P">8{ P/aZbOC7M&rOhu{jPhOմ(k!ķL+ȤGO'G #Q>آ7<* 7nBNOUղנ~ve6\Du//%1;]%\Ѿ5%uY?azNN}Hk7(.3Y!Y9#O+&\|tMA߰ύ.;hx U+LRBj̀{x&0gZAC2yE Z Lk#=72f!1cmM# Fyr_7`![7P%Ԕ_綟Pu$Jd {z"} @<Ԥl5veϋ )y vJ;wFhxtDH>=Ǚ#"ce"ʾ|î l躍I,}^(bb!w' b+9U'̥tF!|0wcS@w Z6 bEU zaAJEkmƟmRȡb{L06] JR1&yaWqʨo'xsц4mr%͓26ԫ!_R[%b)S9AUa8Q.!au'̛O̺]MsF ҤBYQtܗL%% О 3BkvqtnZCHOˇlqi4zqTz'-=壢pAS?,\C2#xx5=>vɗK% f&q MRG C׊!}e;y(8V%m3t Oat7Ld??6L//0'XQ_X<|E÷m,72ह*zIEGrdžPch5fYF~RqRO$w6%t2BYVN=& Rt$yO~/EN# =wKX+ɏ2{.2ҭs`EL^}R0<&_YyOARBOF'Ex {nj95i1,^&H#o)Ev?H8#sW{%$Q4Ӎ$򕣕fGpOnV @c){~:;pH8 i9(-졎^H!0u 7&w`( %t\vx7TTx4V;ОF(.SDZ_P"_X肉P Ev +!EJה|)N'9Є茉D HcaV> t7쳦,(<2CukMHjk,VO+too !Mȇwvqg(uۗ_g߭fB O b{m:Vg5te+ևܡaE!ǂîo>U1)>[h?N{CI$`dIp'Hܩ5 PKRx~W0泳56;0:Fj<&QX@tghw9Cy7\/D/!fH[q..uY&ҵ,HR  ^osg1;]F2 Sgܛ~Q5 H6Bv{l6;S7 Ɩ`v讆6}p䍚GNʼg"sAun%3QrGNBs/u)SҚzn#3=iR*Z]M1{[bxQ*{x5oɂr%v\hryrO[T+|ki^. ٞW&!ky2hTVʲ_nvQ`ҬKٕ8_s Dσ*0Fxu$=f&Ud&/7i cFu@-;i>iMj 8$hA|>/:~#a}:S9L/sb/L{= pp)3䊙FYO]wJm *jJ|#oR|YHF[jAep3Aٛ*jn"O8$f*)賢J]\%ƃ W7{g];,+C Aymf QI) Ua 5"U\#pX77϶߾#n(6L+u@= a\8*0|j&H /Ԋ{XɬIRWRp sJFI- J Y|y=7F_5OuG&ʐGn,1B}[Ci>:f m40-}i43/ X馢b2t˾ TPFҙd|ˋWRe` RyO9Mt)z,қnmt !x*(Nj}C~RwDeo ׍qw1{-&a݀ae*UWwM~+r&\}8x6L6|3/ÁΎWlS$yi1ͤ[(^, MAYȳdOA1L?K ar nх7c:TZ'siz*ョ) hMX4q9 /\d 3uƙ9]j) } U ȍ+80~&'l5s|uG0No>cuZTͦݺWrppOVIX80ӡ]bu?!tn6άt5 d.okip0ќ߰ΉH JoIURπ GktVsnJrLVndvNd?ZN[`[ؗ^sHPf[#.gCWFZ/幕2R) H6b4$k۪9GQ;ۂT.-@,;bڗvSە_r f<990,Le̙,vUan x+E8 >_ĊqU q[a` "'!B2ws=ICwڿMRAIfMA)"Q5*LvitHldÀzvCC|r}ÿWBShHlO ~K9r ➉!8?n0b\b_@p eJ1d+>5m QwQ9gxn]?8}~< |EV=mj }!Y[ƴ(QK8ZX|8bVi)A´t+Y?vUD؇*T]._LjZJ&~% fZ Wz~@ԟ /l6lSqHؓw c2~f1YkD(=1i+~k}YJ`@?HU~i%%: -p܏B,>eoP7535:f(lh[˱d䬅.hgU,@.D_#{_ bݸeR@^dzDTw RBձ?|_yT}+HC!mp(X_\P0dh6 QciӍ+aJۭJ~7$xhȳW+FF!P;t1U&6kBqѩE523i3fQq}Cw?ΉN hyN## p{8& endstream endobj 40 0 obj<> endobj 41 0 obj<> endobj 42 0 obj<> endobj 43 0 obj<> endobj 44 0 obj<> endobj 45 0 obj<>stream 1999-12-23T16:43:45Z Parlance Publisher 5.0/(Xyvision Postscript Formatter) 3.0 3 Acrobat Distiller Daemon 3.02b for Solaris 2.3 and later (SPARC) application/pdf LAM 6#6 uuid:24c85efb-133f-4dee-8a60-4d5c9d8bd315 uuid:9e100a79-1b66-4457-87f5-e7852fe6f7a9 endstream endobj 46 0 obj<> endobj xref 0 47 0000000000 65535 f 0000179509 00000 n 0000179635 00000 n 0000179794 00000 n 0000191302 00000 n 0000191428 00000 n 0000191555 00000 n 0000203744 00000 n 0000203870 00000 n 0000204048 00000 n 0000251076 00000 n 0000251205 00000 n 0000251394 00000 n 0000508994 00000 n 0000509042 00000 n 0000509171 00000 n 0000509361 00000 n 0001146987 00000 n 0001147116 00000 n 0001147284 00000 n 0001384836 00000 n 0001384965 00000 n 0001385114 00000 n 0001398024 00000 n 0001398153 00000 n 0001398324 00000 n 0001413932 00000 n 0001414061 00000 n 0001414210 00000 n 0001431024 00000 n 0001431153 00000 n 0001431302 00000 n 0001438132 00000 n 0001439172 00000 n 0001439369 00000 n 0001445273 00000 n 0001445321 00000 n 0001446376 00000 n 0001446489 00000 n 0001446552 00000 n 0001459226 00000 n 0001459529 00000 n 0001459613 00000 n 0001459673 00000 n 0001459800 00000 n 0001459866 00000 n 0001461279 00000 n trailer <> startxref 116 %%EOF